Method for preparing open-loop lovastatin

A lovastatin, ring-opening technology, which is applied in the field of preparation of ring-opening lovastatin from Monascus to achieve the effects of less pollution, mild working conditions and simple equipment
CN101659923AInactive Publication Date: 2010-03-03BEIJING WBL PEKING UNIV BIOTECH
0 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING WBL PEKING UNIV BIOTECH
Publication Date
2010-03-03
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a method for preparing open-loop lovastatin by using monascus purpureus, which is a biological conversion method for utilizing monascus to produce enzyme and hydrolyze closed-loop lovastatin into the open-loop lovastatin. The method comprises the following steps: selecting and culturing a monascus strain CGMCC NO.0272; putting the cultured monascus strain CGMCC NO.0272 intoa fermentation medium for fermentation; preparing crude enzyme solution by a salting out method; performing substrate preparation; performing enzymatic conversion reaction; and performing other steps. The method for preparing the open-loop lovastatin by using the monascus purpureus adopts microbial conversion means, and compared with chemical means, the microbial conversion means has the advantages of moderate condition, simple equipment, less public hazard, quick reaction rate and relatively environmental protection.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a method for preparing lovastatin, in particular to a method for preparing ring-opening lovastatin by using monascus. Background technique

[0002] Lovastatin (LOVASTATIN), chemical name: (S)-2-methylbutanoic acid-(1S,3S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3 , 7-dimethyl-8-{2-[(2R,4R)-4-hydroxyl-6 oxo-2-tetrahydropyranyl]-ethyl}-1-naphthyl ester; molecular formula is C 24 h 36 o 5 , molecular weight 404.55.

[0003] Lovastatin is a fermentation product of Monascus and Aspergillus terreus, a 3-hydroxy-3-methylpentanediate coenzyme A (HMGCoA) reductase inhibitor, which has a very obvious effect of lowering blood lipids. Widely used in clinical and health products. Lovastatin has two structural forms of open ring and closed ring. Because the closed ring structure is relatively stable, it is used as the structural form of chemical medicine products for clinical use. In 1987, Merck's lipid-lowering drug lovastatin (lovastatin, M...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More