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Composition and methods for the enterosorption and management of toxins

A technology of calcium aluminosilicate and composition, which is applied in the direction of drug combination, active ingredients of aluminum/calcium/magnesium, anti-toxic agent, etc.

Inactive Publication Date: 2009-09-02
TEXAS A&M UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0044] Those of ordinary skill in the art will appreciate that there is insufficient scientific and clinical evidence in the literature for or against the use of certain clays in medicine, however, current medical evidence tends to teach against the use of clays as Safe treatment of toxin-poisoned patients or patients predisposed to liver cancer

Method used

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  • Composition and methods for the enterosorption and management of toxins
  • Composition and methods for the enterosorption and management of toxins
  • Composition and methods for the enterosorption and management of toxins

Examples

Experimental program
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Embodiment 1

[0069] Several strategies are available for dealing with aflatoxins in agricultural products, the simplest of which require isolation and destruction of the source of contamination. However, this approach is often not practical because alternative food supplies may not be available, or alternative supplies may not be economically viable. One of the most promising and well-studied approaches for the prevention of aflatoxin poisoning in livestock involves the incorporation of clay or various "binders" into diets contaminated with these toxins. The additives reduce the bioavailability of the toxin in the gastrointestinal tract; that is, they act as sequestrants (gutabsorbents) for the toxin, thus reducing absorption and distribution in the blood and target organs.

[0070] Adsorbed clay minerals have been reported to be associated with aflatoxin B in liquid 1 combined. In the first enteric adsorbent study on aflatoxin, calcium montmorillonite clay, commonly used as an anti-caki...

Embodiment 2

[0110] Primary hepatocellular carcinoma (HCC) has a unique geographic, sex, and age distribution that may be determined by specific causative factors (ie, hepatitis and aflatoxin exposure). The incidence of HCC varies considerably according to geographic location. The distribution of HCC also varies among different ethnic groups in the same country and in different regions of the same country.

[0111] Areas of high incidence (more than 15 cases per 100,000 people per year) include sub-Saharan Africa, China, Hong Kong, and Taiwan. More than 40% of all HCC cases occur in China, where 137,000 cases occur annually. In contrast, North America, South America, most of Europe, Australia, and parts of the Middle East have a very low incidence, reporting fewer than 3 cases per 100,000 people per year. However, the incidence in the United States has increased over the past 20 years, likely due to many people with long-term chronic hepatitis C.

[0112] Men are more susceptible to HCC...

Embodiment 3

[0121] Aflatoxins (AF) are harmful by-products of mold growth, mainly produced by the fungi A. flavus and A. parasitica. Naturally occurring AF (such as B 1 , B 2 , G 1 and G 2 ) have been listed as dangerous pollutants present alone or in combination in a variety of foods consumed by humans and animals. Aflatoxin B 1 (AFB 1 ) have been characterized as genotoxic, immunotoxic and hepatocarcinogenic. Humans and animals with acute aflatoxin poisoning usually have symptoms based on dose including jaundice, low-grade fever, gastrointestinal bleeding, edema, depression, anorexia, diarrhea, fatty liver, ascites, abdominal pain and possibly liver failure and death. Previous reports have revealed strong dose-response relationships between exposure to AF and growth impairment, particularly developmental impairment (reflecting chronic malnutrition) and underweight (marking acute malnutrition), as in Benin, Togo, and West Africa. seen in children.

[0122] One of the most severe ...

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Abstract

A composition and method for use as a preventive therapy to mitigate the effects of environmental toxins, and particularly aflatoxins in a subject. The subject may be at risk for hepatocellular carcinoma and aflatoxicosis. The composition comprising: an effective amount of an isolated low sodium, calcium aluminosilicate clay in a powder form, wherein the isolated low sodium, calcium aluminosilicate clay contains acceptable levels of dioxins and priority toxic heavy metal contamination, and is capable of preferentially binding aflatoxins in the gastrointestinal tract.

Description

[0001] This application claims U.S. provisional patent application titled "Compositions and Methods for Intestinal Adsorption and Treatment of Aflatoxins in Persons at Risk for Hepatocellular Carcinoma and Acute Aflatoxin Poisoning," filed June 27, 2006. Priority of patent application Serial No. 60 / 816,824, the entire contents of which are incorporated herein by reference. [0002] Statement of Rights to Inventions Resulting from Federally Sponsored Research [0003] The research of the present invention was obtained from federal funds or support from NIH, USDA and USAID (NIHP42-ES04917, USDA Animal Health Grant 9700579, USAIDLAG-G-00-96-90013-00, TAES H6215 and NIH Center Grant ES09106). Background technique [0004] The present invention generally relates to clay-based sorbent compositions and methods for reducing the bioavailability and toxicity / carcinogenicity of toxins in the system by sequestering these toxins in the gastrointestinal tract (ie intestinal adsorption). Mo...

Claims

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Application Information

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IPC IPC(8): A61K35/02A61K31/366A61P35/00A61P43/00A61K33/06A61K35/10
CPCA61K31/366A61K33/06A61K35/02A61P35/00A61P39/00A61P39/02A61P43/00A61K2300/00
Inventor 蒂莫西·D·菲利普斯罗伯特·亨特·卡彭特
Owner TEXAS A&M UNIVERSITY
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