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Rodgersia sambucifolia hemsl medicinal composition with good stability and high bioavailability as well as preparation method and application

A technology of availability and stability, applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of low absorption rate of active ingredients, limited applicable population, high hygroscopicity, and improve bioavailability. degree, good palatability, and the effect of reducing hygroscopicity

Active Publication Date: 2012-12-26
YUNNAN SHIPURUI BIOLOGICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after years of use, it has been found that the drug has certain shortcomings: such as high hygroscopicity, short validity period (only about 1.5 years), low absorption rate of active ingredients, and limited applicable population, etc.

Method used

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  • Rodgersia sambucifolia hemsl medicinal composition with good stability and high bioavailability as well as preparation method and application
  • Rodgersia sambucifolia hemsl medicinal composition with good stability and high bioavailability as well as preparation method and application
  • Rodgersia sambucifolia hemsl medicinal composition with good stability and high bioavailability as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Raw material formula: Yantuo extract 25.0g, aspartame 2.0g, glucose 145.0g, orange flavor 1.5g, bentonite 826.5g.

[0043] Preparation method: take Yantuo and crush it into coarse powder, put it in an ultrasonic extraction tank, add 8 times the weight of 75% ethanol to soak three times, soak for 48 hours for the first time, soak for 24 hours for the second and third times, combine the soaking liquid, Recover ethanol under reduced pressure at 50°C and concentrate it to a clear paste with a relative density of 1.10; add hydrochloric acid to the clear paste to adjust the pH value to 1.5, let it stand overnight, filter, and concentrate the filtrate under reduced pressure at 50°C to a relative density of 1.30 thick paste; add 6 times the amount of 75% ethanol to the thick paste to dissolve, add activated carbon to decolorize, filter, concentrate the filtrate to 1 / 2 of the volume of the thick paste, let it stand, filter, take the precipitate and dry it at 80°C, that is Deyan Tu...

Embodiment 2

[0047] Raw material formula: Yantuo extract 27.5g, aspartame 3.5g, glucose 182.5g, orange flavor essence 2.5g, bentonite 784g.

[0048] Preparation method: take Yantuo and crush it into coarse powder, put it in an electromagnetic wave extraction tank, add 6.5 times the weight of 80% ethanol to soak three times, soak for 44 hours for the first time, soak for 24 hours for the second and third times, combine the soaking liquid, Recover ethanol under reduced pressure at 55°C and concentrate it to a clear paste with a relative density of 1.10; add phosphoric acid to the clear paste to adjust the pH value to 2.0, let it stand overnight, filter, and concentrate the filtrate under reduced pressure at 55°C to a relative density of 1.20 thick paste; add 5 times the amount of 80% ethanol to the thick paste to dissolve, add silica gel to decolorize, filter, and concentrate the filtrate to 1 / 2 of the volume of the thick paste, let stand, filter, and dry the precipitate at 70°C, that is Dey...

Embodiment 3

[0052] Raw material formula: Yantuo extract 30.0g, aspartame 5.0g, glucose 220.0g, orange essence 3.5g, bentonite 741.5g.

[0053] Preparation method: take Yantuo and crush it into coarse powder, put it in a microwave extraction tank, add 5 times the weight of 85% ethanol to soak three times, soak for 48 hours for the first time, soak for 20 hours for the second and third times, combine the soaking liquid, Recover ethanol under reduced pressure at 60°C and concentrate it to a clear paste with a relative density of 1.20; add glacial acetic acid to the clear paste to adjust the pH value to 2.5, let stand overnight, filter, and concentrate the filtrate under reduced pressure at 60°C to a relative density of 1.40 thick paste; add 4 times the amount of 85% ethanol to the thick paste to dissolve, add adsorption resin to decolorize, filter, concentrate the filtrate to 1 / 2 of the volume of the thick paste, let it stand, filter, take the precipitate and dry it at 60°C , that is, Yantuo...

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Abstract

The invention discloses a rodgersia sambucifolia hemsl medicinal composition with good stability and high bioavailability as well as a preparation method and an application of the medicinal composition. The composition provided by the invention comprises 1.5 to 5.0% by weight of rodgersia sambucifolia hemsl extract, 5.0 to 24.0% by weight of flavoring agent and the balance of bentonite. The method provided by the invention comprises the processes of active component extracting, ingredient processing and mixing; the active component extracting means grinding the rodgersia sambucifolia hemsl into coarse powder, extracting with ethanol, concentrating to obtain a paste, adjusting the pH value, filtrating and concentrating to obtain a thick paste, diluting, decoloring, filtrating and concentrating to obtain a concentrated thick paste, standing, filtrating the precipitate, and drying to obtain a rodgersia sambucifolia hemsl active component extract; crushing and screening the bentonite; and mixing a main material and the adjuvants to obtain a target composition. According to the invention, the rodgersia sambucifolia hemsl extract is taken as an active component of the medicinal composition, and the formula is reasonably arranged to completely give full play to the effect of the adjuvants on improving the physical and chemical property of a medicinal preparation and the gastrointestinal absorption capacity of the human bodies, so that the stability and the bioavailability of the preparation are improved, the taste is improved, and the crowds with fear of sugars suitable for the composition can be expanded.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, and further belongs to the technical field of preparation of medicines for treating intestinal diseases by using the extract of rock tuo Tuo pharmaceutical composition and its preparation method and application. Background technique [0002] Yantuo (Yán Tuó), aliased as Mao Qinghong, Jiuye Yantuo, Maoqi, Maotou Sanqi, Xuesanqi (Yunnan), belongs to the saxifrage family and belongs to the genus Southwest Guideng ( Rodgersia sambucifolia Hemsl. ), used as medicine with rhizomes and roots. Yantuo is bitter, astringent, cool in nature, has the effects of clearing heat and cooling blood, regulating menstruation and relieving pain; it is mainly used for the treatment of enteritis, dysentery and other intestinal diseases, and also has auxiliary treatment for dysmenorrhea, menorrhagia or rheumatoid arthritis, bruises It can also be used externally to treat traumatic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P1/00A61K33/06
Inventor 龙祥王海燕杨瑜王朝军张秋玲胡志祥
Owner YUNNAN SHIPURUI BIOLOGICAL ENG
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