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Composition for intestinal delivery

A composition and systemic delivery technology, applied in the field of composition, oral physiologically active products and intestinal delivery, can solve the problems of improved absorption and increased cost

Inactive Publication Date: 2008-02-06
佩罗斯美国公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This leads to the question whether absorption via the oral route can be enhanced
Because most patients are unable to self-administer parenteral agents, it is often necessary to administer such drugs in an outpatient setting, making them costly to use

Method used

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  • Composition for intestinal delivery
  • Composition for intestinal delivery
  • Composition for intestinal delivery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0121] Rainbow trout (Oncorhynchus mykiss) and brook char (Salvelinus fontinalis)

[0122] Growth Enhancement in Humans: Feeding Recombinant Bovine Somatotropin Using a Novel Delivery System

[0123] The aquaculture industry worldwide has undergone rapid expansion over the past two decades and currently represents the fastest growing agricultural sector. The sector has grown at an annual rate of 10.9 percent since 1984, compared to a 3.1 percent increase in livestock meat production on Earth. The fastest growing livestock over the same period was chicken production with an APR of 5.3, followed by pork at 3.4, lamb and lamb at 1.4, and beef and veal at 0.9. Aquaculture's contribution to world food fish terminals more than tripled from 1984 to 1995, from 11.5 percent to 25.6 percent. The increased demand for seafood products has been linked to a reduction in the capture of wild materials and will continue to benefit the development of the aquaculture industry.

[0124] Aquacu...

Embodiment II

[0149] Growth enhancement of rainbow trout (Oncorhynchus mykiss). Recombinant bovine somatotropin was injected intraperitoneally.

[0150] method

[0151] A dose of 20 μg bST / g live body weight was administered intraperitoneally (IP) per fish per week for 6 weeks.

[0152] result

[0153] Figure 4 depicts that intraperitoneal injection of recombinant bST induced a significant increase in body weight gain in rainbow trout.

Embodiment III

[0155] Evaluation of proteolytic enzyme inhibitors present in feed ingredients

[0156] Extraction Enzyme Protocol

[0157] Material

[0158] 1. Centrifuge Sorvall type

[0159] 2. Bench-top mixer

[0160] 3. Materials for dissection (scissors)

[0161] 4. Centrifuge bottle

[0162] 5. Disposable cuvettes for spectrophotometer

[0163] 6. Microcentrifuge tube 1.5ml

[0164] 7. Spectrophotometer

[0165] 8. Vortex machine

[0166] 9. Microplate Reader from Biorad

[0167] 10.50mM Tris-HCl pH=7.5

[0168] 11. Coomassie blue staining solution

[0169] 12. BSA (1mg\ml) standard solution

[0170] 13. TCA 20%

[0171] 14. Rainbow trout pancreas and duodenum tissue

[0172] 15. 50mM Tris-HCl pH=9 containing 0.5% casein

[0173] 16.50mM Tris-HCl+CaCl 2 10mM pH=7.5

[0174] Enzyme extraction

[0175] 1. The rainbow trout are weighed and slaughtered.

[0176] 2. Dissection was performed to remove the proximal small intestine from the fish.

[0177] 3. After weigh...

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PUM

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Abstract

The present invention relates to a new composition, use and method for oral administration to a human or an animal of a physiologically active agent comprising neutralizing agents to increase pH in the digestive system to prevent denaturation, inhibitors of digestive enzymes to substantially prevent enzymatic digestion, and at least uptake-increasing agents which increases intestinal absorption of a physiologically active agent, a drug and / or a nutrient.

Description

Background of the invention [0001] (a) Field of Invention [0002] The present invention relates to a composition and a method for oral administration of a physiologically active product and intestinal delivery. The administered physiologically active products of the present invention enable better systemic delivery and immune induction, and have demonstrated enhanced nutritional, nutraceutical and therapeutic capabilities. [0003] (b) Description of prior art [0004] The usual route of therapy involving protein and peptide drugs is parenteral administration (eg, by injection). This is mainly due to the inability of these drugs to be absorbed through the gastrointestinal tract. However, injections are painful and administration is sometimes difficult relative to other dosage forms. Patient compliance is an important reason, also because some of these drugs may need to be administered to young or elderly patients. Oral delivery is preferred over injection for patient acc...

Claims

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Application Information

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IPC IPC(8): A61K47/12A23K1/16A23K1/14A23K1/175A61K47/18A61P1/00A61P5/00A23K1/165A23K1/18A61K9/00A61K47/02A61K47/04A61K47/20A61K47/22A61K47/24A61K47/26A61K47/28A61K47/32A61K47/42A61K47/46
CPCA23K1/188A23K1/164A23K1/1609A23K1/165A61K47/02A61K47/42A61K47/26A23K1/1753A61K47/46A23K1/1631A61K9/0056A61K47/183A61K47/28A23K20/105A23K20/147A23K20/158A23K20/168A23K20/24A23K50/80Y02A40/818A61P1/00A61P3/02A61P31/04A61P5/00A23K20/184A61K47/06
Inventor G·W·范登伯格
Owner 佩罗斯美国公司
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