174results about How to "Strong response" patented technology

A coil for the treatment of vascular aneurysms is disclosed. The coil is formed from filamentary members interlaced to form a three-dimensional substrate. The substrate is deformable between a collapsed state wherein it fits within a catheter, and an expanded state, which it assumes once deployed from the catheter into the vascular aneurysm. The three-dimensional shapes of the substrate include flat sheets biased into a helix or a tubular forms biased into figure eight loops, helical loops or a sinusoid. Bioactive characteristics may be imparted to the coil through the use of coatings or materials that provoke a healing response in living tissue.

Ischemia-reperfusion injury commonly results from any surgical procedure requiring stopping of blood supply to an organ followed by reperfusion such as in heart bypass, angioplasty or organ transplant. The invention discloses a method to harness the innate power of repetitive transient ischemia in protecting organs against imminent ischemia-reperfusion, or any patho-physiological insults. This method of optimal remote ischemic preconditioning (ORIP) comprises of utilizing a pair of programmable pneumatic cuffs that inflate/deflate alternately occluding blood circulation to each of the limbs for pre-defined time intervals. The apparatus delivers maximal ORIP dose in shortest possible time either as an EMS procedure during patient transportation to hospital, as elective pre-surgery treatment, or in critical care for preventing multiple-organ-dysfunction-syndrome. ORIP can be self-administered and remotely monitored by clinician especially in chronic patients for homeostasis of malfunctioning target organs. ORIP may also be deployed as adjunct in angioplasty, gene/stem cell heart repair therapies.

The present invention relates to a nanowire array (15, 16) for electrically-controlled elution of a therapeutic composition (5) comprising a plurality of nanoscopic-sized wires (12, 12), nanowires, attached to an electrically conducting solid support (7), said nanowires formed from electroactive conjugated polymer (4) containing or doped with said therapeutic composition (5) coated over a plurality of nanoscopic sized electrically conducting protrusions (8). It also relates to a method for preparing a nanowire array and an electrode.

A fundus camera using infrared light sources, which included an imaging optical path and an optical path for focusing and positioning and two optical paths share a common set of retina objective lens, and a computer-assisted method for retinal vessel segmentation in general and diabetic retinopathy (DR) image segmentation in particular. The method is primarily based on Multiscale Production of the Matched Filter (MPMF) scheme, which together the fundus camera, is useful for non-invasive diabetic retinopathy detection and monitoring.

This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.

Magnetic materials and methods exhibit large magnetic-field-induced deformation/strain (MFIS) through the magnetic-field-induced motion of crystallographic interfaces. The preferred materials are porous, polycrystalline composite structures of nodes connected by struts wherein the struts may be monocrystalline or polycrystalline. The materials are preferably made from magnetic shape memory alloy, including polycrystalline Ni—Mn—Ga, formed into an open-pore foam, for example, by space-holder technique. Removal of constraints that interfere with MFIS has been accomplished by introducing pores with sizes similar to grains, resulting in MFIS values of 0.12% in polycrystalline Ni—Mn—Ga foams, close to the best commercial magnetostrictive materials. Further removal of constraints has been accomplished by introducing pores smaller than the grain size, dramatically increasing MFIS to 2.0-8.7%. These strains, which remain stable over >200,000 cycles, are much larger than those of any polycrystalline, active material.

A magnetic materials construct and a method to produce the construct are disclosed. The construct exhibits large magnetic-field-induced deformation through the magnetic-field-induced motion of crystallographic interfaces. The construct is a porous, polycrystalline composite structure of nodes connected by struts wherein the struts may be monocrystalline or polycrystalline. If the struts are polycrystalline, they have a “bamboo” microstructure wherein the grain boundaries traverse the entire width of the strut. The material from which the construct is made is preferably a magnetic shape memory alloy, including polycrystalline Ni—Mn—Ga. The construct is preferably an open-pore foam. The foam is preferably produced with a space-holder technique. Space holders may be dissolvable ceramics and salts including NaAlO₂.

The present invention relates to preventive, therapeutic, and diagnostic compositions and methods employing lymphocytes having T-cell receptors and chimeric receptors. In particular, the invention relates to pre-selected dual-specificity lymphocytes having endogenous T-cell receptors and chimeric T-cell receptors that recognize a strong antigen and tumor associated antigens where the pre-selected population of adoptively transferred lymphocytes is activated by in vivo immunization, thereby increasing the effectiveness of adoptive immunotherapy.

The present invention is in the fields of medicine, immunology, virology and molecular biology. The present invention provides a composition comprising a modified virus-like (VLP) particle derived from RNA bacteriophage AP205. The invention also provides a process for producing the aforementioned VLP. The modified VLP disclosed in the present invention is useful in the production of compositions for inducing immune responses for the prevention or treatment of diseases, disorders including infectious diseases, allergies, cancers and drug addiction. Moreover, the modified VLP disclosed in the present invention is, in particular, useful to efficiently induce self-specific immune responses, in particular antibody responses.

Nanoconstructs having three components: (1) biodegradable nanopolymers and nanoparticles, (2) immunodrugs such as CpG, and a (3) tumor binding device, which are actively targeted to tumor cells such as melanoma cells through receptor-mediated uptake and methods of using the same are described. Antitumor immunity is further enhanced by combination of PG-CpG nanoconstructs with agonists of positive costimulatory signals and inhibitors of negative immune regulatory signals.

The invention relates to a vision significance detection method based on Weber's law and center-periphery hypothesis. The conventional method is low in resolution, incomplete in extracted object outline and high in computational complexity. The method comprises the following steps of: extracting color component graphs of original images in a CIELAB space by adopting a color transformation method; calculating horizontal gradient difference excitation values and vertical gradient difference excitation values of pixel points in the 1 color component graph, the color component graph and the b color component graph according to the Weber's law; calculating the difference excitation value of a random gradient direction according to the horizontal gradient difference excitation values and the vertical gradient difference excitation values, and counting a difference excitation value histogram; and finally, establishing local significance excitation vectors of the pixel points to obtain local significance judgment values and overall significance excitation values, and calculating the significance judgment values according to the local significance judgment values and the overall significance excitation values. By the method, vision significance graphs with the same resolution as the input images can be acquired, and stronger response in a significance region can be realized.

The present invention relates to a graphene composite magnetic photocatalyst Mn1-xZnxFe2O4/BiVO4/RGO preparation method belonging to the field of inorganic photocatalytic materials. A heterojunction composite photocatalyst formed by loading sheet layer graphene (RGO) and magnetic Mn1-xZnxFe2O4 particles onto monoclinic BiVO4 has strong conductivity, impedance value (103 Omega.cm<2>) of the heterojunction composite photocatalyst is significantly less than impedance value (351 Omega.cm<2>) of BiVO4 or impedance value (206 Omega.cm<2>) of Mn1-xZnxFe2O4 / BiVO4; the composite catalyst can be used for visible light photocatalytic degradation of rhodamine B, 1.5 hour degradation rate is up to 96%, specific saturation magnetization is 8.21emu . g<-1>, due to strong magnetism, the composite photocatalyst is easy to recover by use of an applied magnetic field, the recovery rate is not less than 89%, degradation rate on RhB of the recovered catalyst is still 85%; the graphene composite magnetic material prepared by the method has high visible light catalytic activity, strong stability and large recovery rate, can significantly improve the removal efficiency and speed when being used in optical degradation of organic pollutants, and has good use prospects.

The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising a virus like particle (VLP) and at least one GnRH peptide or fragment or variant thereof linked thereto.

The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of GnRH-related diseases and conditions and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

The present invention provides methods of producing biologically active recombinant bFSH and methods of increasing reproduction in mammals, particularly bovine, using recombinant bFSH. Also provided are methods of producing single chain recombinant bFSH. The recombinant bFSH of the present invention increases superovulation, embryo development, and reproductive efficiency in cattle and other ungulates.