149results about How to "Reduce abuse" patented technology

Disclosed in certain embodiments is an oral dosage form comprising: a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and an irritant in an effective amount to impart an irritating sensation to an abuser upon administration of the dosage form after tampering.

Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and a bittering agent in an effective amount to impart a bitter taste to an abuser upon administration of the dosage form after tampering.

A method of and system for identifying an individual drug delivery device and tracing its ownership. An individual drug delivery device, such as a patch, is coded with a unique identifier. Such coding is performed by using a bar code or by storing the identifier in a memory device in the drug delivery device. A database contains a record of the identifier, representing the drug delivery device. The identifier is read upon a transfer of the drug delivery device and the database is updated to include information such as the date of the transfer, the identity of the transferee and the prescribing physician. The ability to retrieve such information regarding specific drug delivery devices can result in the prevention of abuse of controlled substances contained therein.

Disclosed in certain embodiments is a dosage form comprising a plurality of extruded particles comprising an adverse agent or antagonist and a layer disposed about the particles.

To protect a user of a social network, the user's activity is monitored during a baseline monitoring period to determine a baseline activity record. If subsequently monitored activity of the user deviates sufficiently from the baseline activity record to indicate abuse (hijacking) of the user's account, the abuse is mitigated, for example by notifying the user of the abuse. Monitored activity includes posting links, updating statuses, sending messages, and changing a profile. Monitoring also includes logging times of the user activity. Monitoring anomalous profile changes does not need a baseline.

An abuse-resistant pharmaceutical composition includes an oily substance, at least one active ingredient having abuse potential and a capsule. The active ingredient is mixed in the oily substance. The oily substance and the active ingredient are placed in the capsule. In one embodiment the active ingredient includes oxicodone.

The invention discloses a machine vision based real-time diagnosis method and system of vegetable leaf diseases. The system comprises a disease image acquiring hardware part and a real-time diagnosis software part, wherein the image acquiring hardware part consists of a lighting box, a light source bracket, a light source, a round hole at the top of a box body, a digital camera, a camera fixing rod, an optical lens, a polarizer, a box body side door, an objective table and a computer. The method comprises the following steps: acquiring the symptom image of the leaf disease of vegetable to be detected; carrying out image treatment and scab division by utilizing real-time diagnosis software; acquiring the characteristic indexes of scab, such as color, texture and shape; and carrying out real-time diagnosis on the vegetable leaf disease by utilizing a disease identification model. The real-time diagnosis method and system can be directly used for detecting diseases in filed, plastic houses or greenhouses so as to achieve the rapid, stable and real-time diagnosis of various vegetable leaf diseases; no chemical reagent is used, therefore detection cost is reduced and no environment pollution is caused. The real-time diagnosis method and system can be well applied to disease monitoring.

A rotating feed distributor for use in connection with rock crushers and other devices. The feed distributor comprises a platform for receiving rocks and a chute having an inlet and outlet wherein the rocks pass through. The feed distributor is designed to reduce wear by evenly distributing rocks into the crusher. The chute is supported and rotated utilizing a motor, drive belts, a sheave structure, thrust bearings and idler wheels. The sheave structure includes a flange and a face which are generally orthogonal to one another. The belts, thrust bearings and idler wheels each engage with the sheave structure.

A database record controls a license to use a computational component. An input receives an order identifier associated with an order related to a computational component and an interface retrieves order information associated with the identifier. The order information comprises at least one material code. A material code mapping agent compares the material code with at least one material code mapping table to identify corresponding computational component information associated with the material code. In another configuration, a transaction record includes first information associated with the order, the order relates to at least a first computational component and / or feature thereof, a configuration file includes second information different from the first information, the configuration file relates to at least one telecommunication switch / server, and a configuration file processing agent compares some of the first information with some of the second information to form a system record having both first and second information.

The invention discloses a microbial population sensing signal molecule degrading bacterium and an application thereof in disease prevention and control. The degrading bacterium is a pseudomonas nitroreducens strain W-7, wherein the strain is preserved in China Center for Type Culture Collection on November 2, 2017 with preservation number of CCTCC NO: M2017649. The strain is stable in activity; the strain can grow by taking such population sensing signal molecules AHLs as OdDHL and the like as a unique carbon source, and the strain can take an obvious and rapid degrading effect on the signal molecules; meanwhile, the strain takes a relatively good degrading effect on other population sensing signal molecules such as OHHL and DSF; furthermore, the strain also has the characteristics of being simple in culture method, high in growth speed, not easy for variation and strong in adaptive capacity; and the strain has a huge promotion and application potential in such aspects as population quenching direction, inhibiting soft rot disease and preventing and controlling microbial population sensing signal mediated pathological disease harm. With the application of the degrading bacterium provided by the invention, the problem of abuse of pesticides can be relieved, and meanwhile, a new thinking can be prevented from biological prevention and control of plant diseases.

The invention discloses microbial fermentation feed. The microbial fermentation feed is prepared from, by weight, 3-5 parts of a complex microbial agent, 680-730 parts of a fermentation raw material,275-325 parts of an energy raw material, 350-400 parts of water and 1-2 parts of brown sugar by mixed fermentation. The complex microbial agent is made by mixing of 5-6 of bacillus subtilis, enterococcus faecalis, plant lactobacillus, bacillus pumilus, clostridium butyricum, bacillus megaterium, bacillus amyloliquefaciens or lactobacillus casei. By fermentation treatment of the fermentation raw material and the energy raw material with the complex fermentation strain, enzymolysis of coarse fibers in the fermentation raw material is realized, organic nitrogen and inorganic nitrogen, which can be hardly used by animals, in the fermentation raw material are converted into bacterial protein, and macromolecular carbohydrates, which cannot be absorbed by the animal, in the energy raw material are converted into absorbable low-molecule carbohydrates.

The embodiment of the invention discloses a method of synchronizing multiple system accounts. The method comprises steps: an account management system acquires an identifier of a target application system, and the target application system is determined according to the identifier of the target application system; the account management system acquires first accounts in a main account data source corresponding to the target application system; the account management system incrementally stores the first accounts to a sub account data source corresponding to the target application system; the target application system acquires second accounts stored in the sub account data source; and the target application system searches a second account not stored in the main account data source in the second accounts, and the searched second account serves as a legacy account; and the target application system marks the searched legacy account as an abnormal account. By adopting the method of the invention, the unified degree of accounts between multiple systems under the user identity management system can be improved and the account reliability under the identity management system is improved.

The invention relates to a USB state limiting device for reducing abuse of USB device and reinforcing the safety of internal sensitive information of host computer, which comprises a communication module, a control module, a connecting module, a USB port module and an authority module. The communication module is used for realizing communication. The control module is used for controlling the work of internal individual modules in the USB state limiting device, coordinate and control communication work with outside, and monitor whether USB device is inserted into the USB port. The connecting module is used for establishing the connection between the host computer connected with the USB state limiting device and the USB device which is inserted into the USB port. The USB port module is used for connecting with the USB device which is inserted into the USB port to complete information interaction. The authority module is connected with the control module, and at the same time has the functions of approval and authority. The invention further provides a using method of the USB state limiting device.

The invention discloses a bacteria drug-resistance detection system and an operation method thereof. The system comprises a drug sensitive test inoculation instrument, drug sensitive test image acquisition conversion equipment, a drug sensitivity detection kit and a bacterial strain culture device. A medium is arranged in the drug sensitivity detection kit. The drug sensitive test inoculation instrument is used for inoculating a bacterial strain into the drug sensitivity detection kit. The bacterial strain culture device provides a growth environment for the bacterial strain in the drug sensitivity detection kit. The drug sensitive test image acquisition conversion equipment is used for acquiring and converting images of the bacterial strain in the drug sensitivity detection kit. Management software is arranged in the drug sensitive test image acquisition conversion equipment, and the management software is connected to the network. With combination of online and offline, clinical medication is directly guided. The system meets on-site detection requirements, is convenient for data analysis and decision-making for a farm, a veterinary medicines factory and an administrative department, is suitable for current high-level drug resistance situation in our country, and satisfies the need of quantitative networked monitoring of drug resistance. A broth dilution method and an agar dilution method are both considered. The system meets different requirements of large-scale monitoring and scattered sample detection.

The invention discloses an automatic medicine cabinet comprising a cabinet housing, multiple medicine boxes, a cradle, multiple medicine taking-out bags and a display panel of a user interface. The cabinet housing comprises a frame with the front side open, and a first front door and a second front door connected to the frame so as to open and close the front side of the frame. The medicine boxes are used for storing medicine and arrayed inside the frame in a removable manner. The cradle is used for collecting medicine taken out from at least part of the medicine boxes. The medicine taking-out bags are installed on the first front door and used for exposing medicine falling therein from the cradle to be taken out of the cabinet housing. The display panel is installed on the second front door so as to show a display in front of the second front door. The first front door is opened and closed in a manner of clockwise and anticlockwise rotating based on a rotating shaft extending along the vertical direction, and the second front door is opened and closed in a manner of reciprocating in the direction perpendicular to the rotating shaft.

A pharmaceutical paste composition comprising an active ingredient such as an addictive substance, a controlled release agent, and a pharmaceutically suitable aqueous or non-aqueous carrier. The composition may comprise one or more of a clay, or an oily, waxy, or fatty substance. The composition may be filled into a capsule or other dispensing device. The composition may reduce dose dumping of an active ingredient. Methods of making and using the composition are also described.

The invention relates to a low-starch puffing compound feed for increasing the growth speed and survival rate of large yellow croakers. The low-starch puffing compound feed comprises Russian white fish meal, Peru fish meal, American chicken meal, wheat gluten, corn gluten meal, soybean meal, high-gluten flour, cassava starch, enzymatic fish soluble slurry, refined fish oil, soybean lecithin, monocalcium phosphate, a vitamin premixture, a mineral salt premixture, choline chloride, lutein, an antioxidant and a mildew preventive. The starch content of the puffing compound feed for the large yellow croakers, disclosed by the invention, is obviously lower than that of a commercial material sold in the market, so that the growth speed of the large yellow croakers can be remarkably increased, theabnormal deposition of fat in livers is reduced, the morbidity and mortality rates of hepatobiliary syndromes are reduced, and the survival rate of a breeding process is increased.

The invention discloses a safe broad-spectrum povidone-iodine preparation and a preparation method and application thereof. Each 1000g of the safe broad-spectrum povidone-iodine preparation is prepared from 10 to 15.5g of polyvinylpyrrolidone, 5.5 to 7.5g of refined iodine, 1.8 to 8.3g of potassium iodide, 0.01 to 3g of potassium iodate, 0.01 to 1.25g of a surfactant, 2 to 8g of a pH regulator andthe balance of water. A weight ratio of the polyvinylpyrrolidone to the effective iodine is (1.6-3.6): 1. The safe broad-spectrum povidone-iodine preparation with a proper dosage cannot cause poisoning and digestive tract injury after being orally taken, can be used for preventing and treating diseases of animals, reducing antibiotic abuse and improving human food safety, and is good in stability, not easy to decompose under the illumination condition and long in preservation time.

The invention discloses a detection method of a bacterial drug resistance gene and a special kit thereof. The kit comprises 296 single-stranded DNAs shown by sequences 1-296. The detection method of the bacterial drug resistance gene comprises the following steps: (1) extracting a genome DNA of a bacterium to be detected, and amplifying the genome DNA by using a complete set of single-stranded DNAs to obtain an amplification product; (2) constructing a sequencing library by using the amplification products based on the Ampliseq technology; (3) sequencing the sequencing library to obtain a sequencing result, and comparing the sequencing result with the drug resistance gene sequence to determine whether the bacterium to be detected carry the drug resistance gene or not. The detection methodand the kit can simultaneously detect multiple drug resistance genes of a sample to be detected with high throughput, rapidness and accuracy, and have a good application prospect.

The invention discloses an application of bacillus proteolyticus in prevention and treatment of pathogenic bacteria and diseases depending on quorum sensing signal molecules. The research finds that the bacillus proteolyticus has a very good effect of degrading dependent quorum sensing signal molecules, an efficient quenching strain of the microorganism quorum sensing signal molecules is screened,which is the bacillus proteolyticus strain S-5, and is preserved in the Guangdong Microbial Culture Collection Center on September 4, 2019, and a preservation number of the bacillus proteolyticus strain S-5 is GDMCC No. 60764. The strain has the activity of quenching AHLs and DSF quorum sensing signal molecules, the quenching effect is stable and remarkable, so that the anti-pathogenicity drug has huge application potential in the aspect of preventing and treating pathogenic bacteria harm caused by AHLs and DSF quorum sensing signals, and the anti-pathogenicity drug taking quorum quenching asan action mode has wide application prospect.

The invention discloses a seed sowing device for same-row intercropping of two types of crops and belongs to the technical field of agricultural seeding machinery. The seed sowing device comprises a power drive device, an accurate-quantity seed supply device and a double-molded-surface seed sowing device, wherein the accurate-quantity seed supply device comprises two rows of seed boxes, a seed quantity adjusting box, seed receiving cups and seed guide pipes. The double-molded-surface seed sowing device comprises a central shaft, a seed sowing plate, seed collecting cups, duckbilled bodies, a rolling housing, a fixing body, end caps, seed groove protecting tiles and other parts. The power drive device comprises a seed sowing shaft, a chain wheel and an adjusting handle. The seed sowing device for the same-row intercropping of the two types of crops fills the blank of automatic mechanical seed sowing for 'same-row intercropping', fully utilizes the growing characteristics of the crops, performs reasonable matching to improve the utilization rate of light energy, land and ground spaces, facilitates improvement of an intercropping effect and promotes agricultural production and income increase.

The invention relates to the technical field of aquaculture pond water quality ecological regulation, and provides a fishery machine used for promoting sufficient exchange of upper and lower bottom water in a culture pond. The machine comprises a submersible pump, a water delivery pipe, a cylindrical float, a spraying head, and the like. When working is started, the submersible pump draws bottom layer water and silt flocs, and the bottom layer water and silt flocs are sprayed through the spraying head and fall onto the water surface, such that upper and lower bottom water can be sufficiently exchanged. Through promoting the sufficient exchange of the upper and lower bottom water of the pond, phenomena of upper and lower water temperature stratification, upper and lower dissolved oxygen stratification and upper and lower pH stratification are broken through; a situation of lower bottom dissolved oxygen deficiency is ameliorated; water upper and lower pH values are kept balanced and stable; and accumulation of harmful substances such as nitrite, hydrogen sulfide, ammonia, methane and the like is effectively reduced. Also, pond bottom silt resuspension and re-release are promoted, such that rich nutrients and rich microbial populations in the sediment are released into water; algal and bacterial phase scientific management is facilitated; and pond ecological environment self-purification capacity is greatly improved.

The invention relates to a microbe culture solution treatment method applicable to MALDI-TOF detection and a rapid identification method. The treatment method comprises the specific steps of adding a hemoculture positive bacterium suspension into glacial acetic acid to lyse red blood cells, carrying out centrifugation to remove supernatant, adding a 10% (volume fraction) glacial acetic acid solution into precipitates to lyse red blood cells, carrying out uniform mixing, then, carrying out centrifugation again to remove supernatant, thereby obtaining precipitates, i.e., a substance to be assayed. The treatment steps are simple, and the reagent cost is low. The invention further discloses a rapid identification method for microbes in a hemoculture positive bottle. According to the rapid identification method, the consumed time is short, clinical reliable identification results can be offered in a short time, the clinical use of antibiotics can be better instructed, and the abuse of the antibiotics is reduced.

The invention discloses a DSF quorum sensing signal degrading bacteria, and applications thereof in plant disease control, and more specifically provides Burkholderia anthina bacterial strain HN-8 preserved at the Guangdong Culture Collection Center, on 24th, November, 2017, and the preservation number is GDMCCNO.60289. It is found in study that Burkholderia anthina, especially the bacterial strain HN-8 possesses remarkable and rapid degrading effect on quorum sensing signal molecule DSF, the degradation performance is stable, quorum sensing communication can be destroyed via degradation of DSF, and great application potential is achieved in prevention and treatment of black rotten caused by xanthomonas campestris, and pathogenic bacteria based on DSF. The Burkholderia anthina bacterial strain HN-8 also possesses relatively high drug resistance on ampicillin, carbenicillin, and streptomycin, so that pesticide or antibiotic abuse and drug resistance are avoided, and novel methods are provided for prevention of plant diseases.

A universal pill bottle cap for securely locking up medications with a high-risk factor for abuse and theft. The pill bottle cap includes a unique locking mechanism, a biometric scanning locking mechanism, a one-step opening process, and a universal applicability. The unique locking mechanism includes a sliding latch on the underside of the cap that will allow a pill bottle to be inserted and the cap to lock around the pill bottle until an authorized user follows a prompt to unlock the cap from the bottle. The biometric scanner opens either the sliding mechanism to allow the pill bottle to be removed or opens the lid to allow access to the contents of the bottle. This depends on a button on the underside of the pill bottle cap. The pill bottle has a microprocessor that drives the functionality of the cap.

The invention relates to a resilient capacity scheduling method and a processing terminal for micro service governance. The method comprises the following steps: step 1, setting a resource pool in themicro service governance system; 2, presetting the basic data of the micro-service governance system; 3, setting corresponding weight value for the microservice system and instances of the microservice system; 4, accessing the micro-service system with the corresponding weight set to the micro-service governance system; 5, collecting data; 6, data cleaning; 7, sample separation; 8, calculating the samples to obtain three type of linear sample sets; 9, training the neural network of the micro-service governance system to obtain the trained neural network; Step 10: using the trained neural network to calculate the system weight value of the micro-service system, and judging to execute the scheduling action according to the calculated system weight value. The invention reduces manual intervention and abuse of resource pool resources, reduces failure rate and improves system efficiency.

A slow-release organic fertilizer for plantation of kiwi is prepared from the following raw materials, by weight, 8-10 parts of perlite, 10-12 parts of rotten fruit and vegetable, 8-9 parts of chicken manure, 14-16 parts of attapulgite, 3-4 parts of EM biological strain, 2-3 parts of agar powder, 6-8 parts of dry pond sludge, 4-5 parts of magnesium sulfate, 4-6 parts of potassium permanganate, 3-5 parts of iron chloride, 6-8 parts of sodium humate, 8-10 parts of ammonium bicarbonate, 4-5 parts of an auxiliary agent and a proper amount of water. The organic fertilizer provided by the invention is a specially-designed fertilizer for plantation of kiwi. By compounding of perlite, the organic fertilizer with an adsorption function is prepared. The fertilizer is firstly ground to a sand shape and then is coated with a layer of agar membrane. Then, elements can effectively be absorbed, use of the fertilizer is minimized and soil hardening is prevented. By addition of magnesium sulfate, potassium permanganate, iron chloride, sodium humate and the like, contents of magnesium, potassium, iron and the like are supplemented for the fertilizer. By addition of acid, soil acidity can be improved. By the use of the organic fertilizer, abuse of fertilizer is minimized, and consumption of energy is also reduced.