Device for simulating gastric digestion and using method of device

A technology for simulating digestion and stomach, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of no detailed simulation and description of the gastric emptying process, and little correlation, etc., to achieve a strong fit for stomach digestion , strong precision effect

Active Publication Date: 2014-03-26
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These patent reports have greatly enriched the devices and methods of use suitable for gastric digestion, but so far, these patents have no detailed simulation and description for the preparation of gastric juice and the emptying process of the stomach. At the same time, some of these patents are only related to animals. Relevant, not very relevant to people

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  • Device for simulating gastric digestion and using method of device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The stomach of plant polysaccharides simulates digestion.

[0016] (1) Preparation of gastric juice.

[0017] Gastric juice is to weigh 37.5 mg of gastric lipase, 35.4 mg of pepsin is added to 150 g of gastric electrolytes (preparation of gastric electrolyte solution: weigh 3.1 g NaCl, 1 g KCl, 0.15 g CaCl 2 , 0.6 g NaHCO 3 , Dilute to a 1 L volumetric flask with deionized water, adjust the pH of the electrolyte solution to 3) with 0.1 M HCl, and then add 1.5 mL CH 3 COONa (1 M, pH 5). Magnetically stir at room temperature for 10 min, adjust the pH of the solution to 2 with 0.1 M HCl, and place in the refrigerator for later use.

[0018] (2) Simulate stomach digestion.

[0019] First, put the plant polysaccharide solution (5mg / ml) that has been digested in the oral cavity in advance in a dish.

[0020] Then, stomach digestion was grouped as follows using the control test method.

[0021] Experimental group 1: Add gastric acid, gastric juice and plant polysaccharide solution to th...

Embodiment 2

[0031] The stomach of cornstarch simulates digestion.

[0032] (1) Preparation of gastric juice.

[0033] Gastric juice is to weigh 35 mg of gastric lipase, 35 mg of pepsin is added to 160 g of gastric electrolytes (preparation of gastric electrolyte solution: weigh 3 g of NaCl, 0.5 g of KCl, 0.1 g of CaCl 2 , 0.5 g NaHCO 3 ,Use deionized water to dilute to a 1 L volumetric flask, use 0.2 M HCl to adjust the pH of the electrolyte solution to 3), then add 2 mL CH 3 COONa (1 M, pH 5). Stir magnetically at room temperature for 20 min, adjust the pH of the solution to 2 with 0.2 M HCl, and place in the refrigerator for later use.

[0034] (2) Simulate stomach digestion.

[0035] First, place the corn starch solution (5 mg / ml) that has been pre-digested in the oral cavity in a dish.

[0036] Then, stomach digestion was grouped as follows using the control test method.

[0037] Experimental group 1: Add gastric acid, gastric juice and corn starch solution to the simulated device to simulate d...

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Abstract

The invention discloses a device for simulating gastric digestion and a using method of the device. The device comprises a gastric reaction vessel, a stirrer, a water bath control system, a computer monitoring system, a gastric emptying pump and the like. The using method comprises the following steps: gastric juice and a solution / dispersion liquid of a substance to be tested are added to the gastric reaction vessel; the stirrer simulates gastric peristalsis; the water bath control system controls the temperature in the reaction vessel; the computer monitoring system monitors the temperature, pH and digestion time in the gastric reaction vessel; the gastric emptying constant-flow pump simulates gastric emptying; digested products are collected; the activity of pepsin is eliminated; the digestion simulation process is repeated for three times; the digestion condition of the substance to be tested is tested. According to the invention, the detailed gastric digestion process is simulated for the first time; gastric digestion conditions after various active or nutritious substances enter a human body can be observed and explored; the simulated environment is in accordance with the physiological environment of a human body; the fitness between the digestion in the simulated environment and the gastric digestion is high; accuracy of control over the environment simulation is high.

Description

Technical field [0001] The invention relates to a device for simulating stomach digestion and a method of use. Background technique [0002] World authoritative journals stated that studying the effects of food or active substances in the human body and their mechanism of action is very important, because the clarification of the mechanism of action in the body can provide a research basis for maximizing the use of food or active substances in the human body. It exerts its physiological effects, and at the same time has guiding significance for avoiding possible adverse side effects. The actual physiological effects of food or active substances largely depend on the product after digestion by the human body. Out of the moral and ethical considerations of human body research, in vitro simulation of human digestion has become the technical key to the research of the mechanism of food or active substances in vivo. Dynamic simulation is carried out by controlling the key points of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/00
Inventor 聂少平胡婕伦谢明勇
Owner NANCHANG UNIV
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