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Method for preparing L-fucoidan in sea tangle

A technology for fucoidose and kelp, which is applied in the preparation of sugar derivatives, chemical instruments and methods, monosaccharides, etc., can solve the problems of low product purity and quality, difficult industrialized production, and imperfect technology, and achieves high yield, The effect of improving purity and high purity

Inactive Publication Date: 2005-09-21
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Until 1966, someone obtained crystalline L-fucoidan by optimizing the hydrolysis and separation conditions, but the purity and quality of the product were not high.
Its technology is not perfect enough to be applied to industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take kelp produced in Qingdao as raw material, extract and purify by water extraction and alcohol precipitation method to obtain purified fucoidan sulfate; then follow the following refining steps:

[0032] 1) Take a certain amount of purified fucoidan sulfate, add water and add acid to carry out hydrolysis reaction, add water and add acid according to the weight ratio of the polysaccharide to water and concentrated acid 1:80:19.6, and then hydrolyze at 100°C-110°C under reflux 4 hours;

[0033] 2) After the hydrolyzate is cooled, neutralize it with barium carbonate to pH 7±0.2, filter, and remove the precipitate;

[0034] 3) Pass the filtrate obtained in step 2) through a 732 strong acid cation resin column, collect the effluent, remove inorganic salts such as K, Na.Ca, Mg, etc., then wash with distilled water of 1 volume of the filtrate, collect and combine the effluent and washing liquid It is the fraction of cation resin;

[0035] 4) Add an appropriate amount of I...

Embodiment 2

[0045] Take 10 g of fucoidan sulfate and place it in a three-neck flask equipped with a stirrer, a constant temperature thermometer and a condenser tube, add 400 ml of water and adjust it to 0.5 mol / L with sulfuric acid, and hydrolyze it at 100°C for 4 hours under reflux. All the other conditions are with embodiment 1.

Embodiment 3

[0047] According to the weight ratio of fucoidan sulfate sample to sulfuric acid is 10:1.96, a certain amount of fucoidan sulfate sample is placed in an ampere tube, sealed and hydrolyzed for 3 hours, and the rest of the conditions are the same as in Example 1.

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PUM

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Abstract

The invention relates to a simple method for preparing L-fucoidan by a kind of sea-tangle from Qingdao as materials which comprises: extracting and purifying the said sea-tangle by the water extract and ethanol precipitation to get purified fucoidan sulfate, then hydrolyzing sulphuric acid, filtering and the filtrate desalting through a column, deoxidizing and decolouring, filtering and the filter liquor rotating and concentrating in vacuum, alcohol depositing, the filter liquor rotating and concentrating to get syrup in vacuum, alcohol depositing, the filter liquor rotating and concentrating to get syrup in vacuum, adding the right amount mixture of alcohol and acetone, and adding several L-fucoidan particles to standard seed and crystal. The production purity is 98.1 %, and the productivity is 16.2-17.0 % in the invention.

Description

technical field [0001] The invention relates to the improvement and application of a method for preparing refined monosaccharides, in particular to a method for preparing L-fucose in kelp, which belongs to the technical field of kelp deep processing. Background technique [0002] Kelp is a kind of large edible brown algae, the whole grass of Laminaria japonica Aresch, which belongs to the phyta Phaephyta, Laminariales, Laminaria family. . There are more than 50 species in this genus, four of which are widely eaten in the world: Laminaria japonica aresch, Rishiri kelp (L. ochotensis-Miy), narrow leaf kelp (L. angustata kjellm) and long kelp (L. longissima Mijabe). In my country, kelp (Laminaria japonica aresch) grows naturally and is cultured artificially. In the initial stage of the development of the seaweed industry, the research on the comprehensive effects of kelp in my country mainly focused on the bulk extracts of iodine, mannitol, and alginate. In recent years, du...

Claims

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Application Information

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IPC IPC(8): C07H1/08C07H3/02
Inventor 徐祖洪赵增芹张全斌牛锡珍张虹李智恩
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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