224results about "Monosaccharides" patented technology

The utility model belongs to the technical field of sugar alcohol preparation, and relates to a system for co-producing L-arabinose and caramel pigment by using xylose chromatography raffinate, which comprises a raw material tank, a nanofiltration membrane separator, a chromatography separation device, an evaporation concentration tank, a crystallization tank, a centrifugal separator and a dryer which are sequentially communicated by pipelines, and the browning reaction assembly is used for mixing the raffinate and the centrifugal mother liquor and then carrying out browning reaction treatment to prepare caramel pigment. The chromatographic separation device is used for separating an extracting solution and raffinate from the flowing nanofiltration permeate, the evaporation concentration tank and the crystallizing tank are used for concentrating and crystallizing the flowing extracting solution into massecuite, the centrifugal separator is used for separating the flowing massecuite into moist sugar and centrifugal mother liquor, and the dryer is used for drying the flowing moist sugar into L-arabinose crystals. According to the utility model, raffinate and centrifugal mother liquor are mixed to prepare a caramel pigment liquid product, so that a caramel pigment additional product is obtained while the utilization rate of saccharide resources is improved.

The invention provides a method for separating and purifying galactose and glucose by using a simulated moving bed chromatography system, and relates to the technical field of saccharide separation and purification. According to the method, the simulated moving bed chromatography system is used for separating and purifying the galactose, operation can be carried out under the set temperature condition, the separation and purification efficiency of the galactose is remarkably improved, continuous large-scale efficient separation and purification of the galactose can be achieved, the separation and purification effect is good, the yield is high, and the product quality is good. According to the method, pure water is used as an eluent, and analyzed and purified compounds are free of damage, low in toxicity, rich in source and low in cost.

The invention belongs to the technical field of sugar synthesis chemistry, and particularly relates to a preparation method of L-mannose. According to the method, 1, 2, 3, 4, 6-penta-O-acetyl-beta-L-glucopyranose is used as a raw material, L-mannose is obtained by modifying and overturning L-glucose 2-OH, the raw material is easy to obtain, and the method is simple in process, low in cost, high in yield and suitable for large-scale production.

Non-dried allulose crystals are dried in a temperature treating step (b) in a drying apparatus at a temperature of about 25° C. to about 70° C., and in a conditioning step (c). The temperature treating step (b) may be carried out (b1) at atmospheric pressure and a residence time of about 5 minutes to about 5 hours. The temperature treating step (b) may be carried out (b2) under reduced pressure and constant temperature and a residence time from about 40 minutes to about 5 hours. The conditioning step (c) may be carried out (c1) over a period of about 30 minutes to 7 hours at a temperature from about 40° C. to about 70° C. The conditioning step (c) may be carried out (c2) over a period of about 15 minutes to about 90 hours at about 30 to about 60% relative humidity, and a temperature of about 25 to about 40° C.

The invention provides an energy-saving production process of xylose. The energy-saving production process comprises the following steps: crushing corncobs; a hydrolysis step; decolorizing with activated carbon; removing carbon; performing high-pressure membrane concentration; a step of adding calcium for neutralization; a step of over-carbon saturation reaction; ion exchange; performing secondary membrane concentration; carrying out secondary decolorization and interchange; moisture is removed through a triple-effect or higher-effect evaporator, and the sugar degree is increased to 65%; cooling and crystallizing the high-concentration liquid to generate high-purity xylose powder, and drying the xylose powder; warehousing finished products, sealing boxes of the obtained finished products, bagging and entering a warehouse; the energy-saving xylose production process has the advantages that the membrane concentration equipment is introduced into the production process before neutralization, so that the volume of all subsequent liquid is reduced, and the scale of subsequent treatment equipment and the consumption of water are reduced. A large amount of organic acid is removed in the concentration process, occupation of the organic acid on resin is reduced, and the exchange rate is increased; all substances except the organic acid are concentrated, and after the concentration is increased, a large amount of salt is removed through neutralization, so that the treatment content of a subsequent impurity removal procedure is reduced.

The invention discloses a method for preparing D-ribose by an adenosine hydrolysis method, belongs to the technical field of preparation of D-ribose, and aims to solve the problem that a method for preparing D-ribose by adenosine hydrolysis does not exist in the market at present. Comprising the following steps of water sample treatment, separation and purification, cation exchange column washing, extraction, crystallization, suction filtration and drying, D-ribose is prepared in an adenosine hydrolysis mode, reaction is few, impurities are few, purification is easy, the hydrolysis reaction yield is as high as 98%-100%, and the conventional fermentation yield is 50%-60%. The hydrolysis reaction provided by the invention has few side reactions, few by-products and easiness in purification, so that high-purity and high-yield D-ribose can be produced. And in addition, impurities are easier to remove when the D-ribose is purified, and the post-treatment difficulty is reduced.

This invention discloses an acid-catalyzed controlled degradation and recycling method for waste polyester and polyester-cotton blended fabrics. Using waste polyester or waste polyester-cotton blended fabrics as raw materials, under the action of an acidic catalyst, in a mixed solvent composed of a polar aprotic solvent and water, the method involves heating and degradation, causing the polyester in the waste polyester or polyester-cotton blended fabrics to depolymerize or co-depolymerize, generating organic raw materials. This invention achieves complete depolymerization and recycling of polyester with a relatively low acid dosage, effectively avoiding the corrosion problems of equipment and excessive degradation of cotton fibers caused by existing technologies. It is also more conducive to the generation and recovery of glucose and 5-hydroxymethylfurfural. Furthermore, the separation steps are simple, greatly reducing separation costs, and high-yield recovery of terephthalic acid, glucose, and 5-hydroxymethylfurfural is achieved, realizing high-value recycling and utilization of various components in textiles, reducing waste, and improving resource utilization.

The present invention relates to inhibitors of protein fucosylation. More specifically, the present invention relates to carbocyclic compounds of formula (I) useful as inhibitors of protein fucosylation, or for the treatment of cancer, autoimmune diseases, infectious diseases, inflammatory diseases, or sickle cell diseases.

The proposal proposes a crystalline allulose with a defined particle size distribution, a process for its production, and its use. This new allulose grade is characterized by its improved shelf life and improved sensory and flavor properties of finished products made with it.

The present invention discloses a method for producing glucosylstevioside using mother sugar and a method for separating and purifying glucosylstevioside to recover glucose, which belongs to the technical field of food additives. [Solution] The present invention provides a method for producing glucosylstevioside using mother liquor sugar, which produces glucosylstevioside using mother liquor sugar as a raw material, thereby enriching the utilization routes of mother liquor sugar and filling the technical gap in the production of glucosylstevioside using mother liquor sugar as a raw material. The produced product also has the advantages of good texture and a high total glycoside content. The present invention provides a method for purifying glucosylstevioside, which recovers and utilizes dextrin, reduces waste liquid discharge, significantly reduces production energy consumption and costs, and improves the yield of high-purity glucosylstevioside. The present invention also provides a method for separating and purifying glucosylstevioside to recover glucose, which is simple and easy to operate, not only produces high-purity glucosylstevioside, but also recovers and utilizes unreacted substrate, thereby reducing costs.

The invention discloses a method for hydrolyzing and saccharifying wood fiber biomass. The method is characterized by comprising the following steps: (1) washing and drying materials; (2) crushing the materials; (3) preparing a material pretreatment solvent; (4) delignification of the material in a pretreatment solvent; (5) filtering the reaction liquid at normal temperature and normal pressure to separate liquid from solid to obtain cellulose; and (6) adding cellulose and polypeptide into deionized water according to a ratio of 2: 1-1: 2 in a solid-to-liquid ratio of 1: 50-1: 100, adding a NaOH solution to adjust the pH value of the solution to 3-8, and reacting at 40-95 DEG C under the protection of nitrogen for 6-16 hours to obtain the product glucose.

The present application relates to allulose crystals, which have an X-ray powder diffraction pattern including peaks at 2θ diffraction angles of 18.8±0.5°, 15.2±0.5°, and 19.5±0.5° in X-ray powder diffraction (XRD) analysis, a sweetener composition containing allulose crystals, and a method for producing allulose crystals.

The invention relates to the technical field of membrane separation, in particular to a glucose mother liquor nanofiltration membrane filtration parameter dynamic optimization process which comprises mother liquor pretreatment, intelligent nanofiltration filtration, clear liquid treatment, residual liquid deep saccharification and finished product preparation. A sulfonated chitosan-graphene modifier is added during pretreatment, a polyamide membrane is adopted for nanofiltration, the temperature, pressure and flow velocity are dynamically adjusted through a PLC-AI system, a TiO-ZnO nano liquid is synchronously added, clear liquid is concentrated, composite saccharifying enzyme is added for reaction, enzyme is added into residual liquid, nano aerogel is saccharified, and a finished product is dried through pulse hot air circulation. According to the process, AI dynamic regulation and control are combined with a nano material, so that the pollution resistance of a nanofiltration membrane is improved, the purity of glucose is improved to 92% or above, the yield is higher than 89%, oligosaccharide residues in saccharified liquid are reduced, drying energy consumption and COD emission are reduced, and high-value utilization of mother liquor is realized.

The invention discloses an application of a zeolite imidazole framework material in catalysis of a carbon-carbon condensation reaction of formaldehyde. The zeolite imidazole framework material is selected from ZIF-Co / IM, ZIF-Co / 2-MIM, ZIF-Co / 2-EIM, ZIF-Co / 2-PIM, ZIF-Co / 2-BIM, ZIF-Co / 4-MIM, ZIF-Co / dClIM, ZIF-Co / Pur, ZIF-Co / BzIM, ZIF-Co / 2-NIM or ZIF-Zn / 2-MIM. The zeolite imidazole skeleton nano-enzyme material can catalyze formaldehyde FA to generate carbon-carbon condensation so as to generate high value-added saccharide small molecules. Through comparison with a high performance liquid chromatogram of a standard substance, catalytic products are mainly C3 compounds glyceraldehyde (GCA) and dihydroxyacetone (DHA), and a small amount of C4 compounds comprise erythritol, threonose and ketulose. Compared with the traditional formaldehyde enzyme, the formaldehyde enzyme has the advantages of high-concentration substrate tolerance, high-temperature resistance and the like.

Provided is a method of separating carboxylic acids comprising (a) providing an aqueous solution comprising (i) one or more monocarboxylic acids, (ii) one or more dicarboxylic acids, and (iii) one or more tricarboxylic acids, and (b) passing the aqueous solution through a set of resin particles wherein the resin particles comprise covalently bound quaternary ammonium groups, and wherein the set of resin particles has a uniformity coefficient of 1.5 or less.

The invention discloses a glucose-fructose efficient separation and high-purity fructose preparation method, and belongs to the technical field of monosaccharide purification, the preparation method adopts functional resin as a stationary phase and water as an eluent, and chromatographic separation is carried out at 55-65 DEG C; the method specifically comprises the following steps: S1, filling a chromatographic column with functional resin, and balancing with 55-65 DEG C water; s2, pumping a mixed sugar solution of glucose and fructose into a chromatographic column; s3, eluting with water at 55-65 DEG C, and respectively collecting a glucose fraction and a fructose fraction; and S4, respectively concentrating, crystallizing and drying the glucose fraction and the fructose fraction to obtain a high-purity fructose product. According to the separation method, the purity of the obtained glucose is 94.4%-95.1%, the recovery rate of the glucose is 97.1%-98.0%, the purity of the obtained fructose is 98.6%-99.2%, and the recovery rate of the obtained fructose is 95.5%-96.8%.

This disclosure relates to a product, a beverage product, and an infusion formulation that each include at least two rare sugars, for example allulose and tagatose. The combination of allulose and tagatose synergistically sweeten the product, beverage product, and infusion formulation. The product includes a food body having a food component and an infusion component. The infusion component includes at least two rare sugars. The beverage product includes a consumable liquid and at least two rare sugars. This disclosure further relates to methods for preparing a food product and beverage product.

The application belongs to the technical field of medicine production, and particularly relates to a preparation method and application of five deuterium-substituted glucose. The method comprises deuterium substitution of D-methyl glucoside, and demethylation of the deuterium-substituted D-methyl glucoside to obtain a target product, namely [2,3,4,6,6'-d5]-D-glucose. The preparation method of the five deuterium-substituted glucose is simple in process route, convenient to operate, mild in experimental conditions, and the synthesized five deuterium-substituted glucose is successfully applied to the description of glycolysis metabolism in a brain glioma model, which is helpful to the clinical conversion application of metabolic imaging technology.

Compositions of de-acylated carbohydrate compounds and methods of making them are provided. The methods can be designed to produce the desired products under conditions of moderate temperature, moderate pH, and without the use of harsh solvents.

The invention discloses an application of a metal organic framework in catalyzing isomerization of glucose into fructose, which comprises the following specific operation steps: adding a metal organic framework catalyst, glucose and a reaction solvent into a reaction container, introducing nitrogen to remove system air, and carrying out catalytic reaction. Centrifuging for solid-liquid separation, adding deionized water with the same volume into the liquid, and hydrolyzing; and the metal organic framework is Zr-NU-906, Zr-NU-1008 or Hf-NU-1008, and the molecular weight of the metal organic framework is 8000-9000. The mass ratio of the catalyst to the glucose is 0.15-1, the catalytic temperature is 25-150 DEG C, the catalytic reaction time is 0.5-24 hours, the hydrolysis temperature is 25-150 DEG C, and the hydrolysis reaction time is 0.5-24 hours. The application effect of the metal organic framework in isomerization of glucose into fructose is good, the glucose isomerization performance is optimal, the fructose yield can reach 46.7%, the fructose selectivity can reach 85.3%, and the metal organic framework has good application prospects.

The invention discloses a preparation technology of astragalus polysaccharide camouflage monosaccharide, and relates to the technical field of biological product production, the preparation technology comprises the following steps: S1, extraction, S2, purification: carrying out purification treatment on astragalus polysaccharide extracted in the step 1, S3, degradation camouflage: dissolving the astragalus polysaccharide purified in the step 2 in a solvent, carrying out degradation treatment on the astragalus polysaccharide by adopting ultrasonic waves, and carrying out purification treatment on the astragalus polysaccharide to obtain the astragalus polysaccharide camouflage monosaccharide. A specific glucan structural unit in a polysaccharide chain is degraded and disguised into a monosaccharide or oligosaccharide structure; and S4, separating to obtain a product. Astragalus polysaccharide is directionally camouflaged as a monosaccharide / oligosaccharide structure, the recognition and uptake efficiency of astragalus polysaccharide by cancer cells is remarkably enhanced, so that the targeting of inducing apoptosis of cancer cells is improved, the structure can effectively activate and train immune cells such as dendritic cells and strengthen anti-tumor immune response, and meanwhile, the product can interfere with a metabolic pathway of cancer cells and reverse the drug resistance of cancer cells, so that the anti-tumor effect is improved. Nutrition supply is blocked to inhibit tumor growth, the production process is green and controllable, and good clinical transformation and industrialization prospects are achieved.

Various processes for preparing C4 aldoses and / or ketones thereof are described. Various processes are described for preparing C4 aldoses and / or ketones thereof from feed compositions comprising glycolaldehyde. Also, various processes for preparing useful downstream products and intermediates, such as erythritol and erythronic acid, from the C4 aldoses and / or ketones thereof are described.

The application provides a preparation method of D-psicose crystal, and particularly relates to a preparation method of D-psicose large-particle-size crystal through cooling and coupling with solvent analysis, and the method comprises the following steps: adding D-psicose seed crystal into a D-psicose saturated solution with a temperature of 50-60 DEG C, cooling and crystallizing through staged temperature reduction to 20-30 DEG C, and adding ethanol when the temperature is reduced to 35-30 DEG C to obtain D-psicose crystal. By controlling the particle number, particle size of the added seed crystal, the addition amount and addition rate of ethanol within the optimal range, the crystal can grow in a good form quickly in the subsequent cooling and coupling with solvent analysis crystallization process. The D-psicose crystal has a high uniformity in particle size, and more than 88wt% of the D-psicose crystal is between 40-60 meshes, the one-way yield of the product reaches more than 60%, the method has strong operability, low energy consumption and high economic benefits.

The invention discloses a preparation method of (a / b)-D-fucose and fucose tetraacetate, and belongs to the technical field of organic synthesis. The preparation method of the (a / b)-D-fucose and fucose tetraacetate is based on a PPh3 / NBS method, the PPh3 / NBS combination is a method for efficiently, highly selectively and mildly converting primary alcohol and secondary alcohol into corresponding alkyl bromide, and the core of the method is to generate Ph3PBr2 to activate hydroxyl. In the whole process, reaction conditions are mild, treatment is simple, needed drugs are cheap and easy to obtain, most of intermediate products are synthesized through a one-pot method, few intermediate products need to be separated and purified through silica gel column chromatography, the operation time of follow-up experimental treatment and separation and purification is omitted, and the time of the whole reaction process is greatly shortened. In addition, due to the fact that repeated purification is not needed, the final yield is guaranteed, the total yield can reach 17%, and the gram level can be reached at a time.

This invention discloses an alloy catalyst, comprising a support and a copper-ruthenium alloy supported on the support, wherein the copper-ruthenium alloy is: Cu 0.7 Ru 0.3 The alloy catalyst prepared by this invention can be used to prepare cyclopentanone. The catalyst has high activity, good stability, and low price. The reactants used in the reaction are renewable, widely distributed, and inexpensive. The preparation of cyclopentanone using the catalyst of this invention does not require the introduction of acid or alkali, which solves the problem of difficult acid treatment in the prior art. Furthermore, it is not corrosive to the reaction equipment, which is conducive to large-scale production.

The present application relates to a method for preparing crystalline D-psicose. In the present application, crystalline D-psicose is prepared by means of combining an evaporative crystallization method and a cooling crystallization method, so that the preparation process is simple, the operation is easy, and the crystallization period is short. In the present application, a seed crystal is added when the solid content is relatively low (70-75%) in an evaporative crystallization process, so that the crystallization process is facilitated, the growth speed of the crystal in each direction is more uniform, the whole crystallization period can be shortened, and the energy consumption is reduced; and after the evaporative crystallization is finished, crystal regulation is carried out, so that the crystal size tends to be equalized, the crystal surface grows to be smooth, and the crystal form is perfected. Cooling crystallization is carried out after the crystal regulation, and the cooling frequency of specific cooling intervals is designed in the cooling process according to the metastable region curve of D-psicose. After crystallization by means of the preparation method of the present application is finished, the obtained crystal has a high yield, a narrow crystal size distribution, a smooth crystal surface, a mirror-like surface, good reflectivity and a regular crystal form.

The method for preparing xylose from bamboo processing excess materials comprises the following steps that the bamboo processing excess materials are smashed, and purified bamboo powder is obtained through sand setting, impurity removal and dilute acid pretreatment; mixing the purified bamboo powder with 1-2% of inorganic acid, hydrolyzing at 110-120 DEG C for 2.5-4 hours, and discharging hydrolysate; adding hot water into the hydrolysis residues for washing, and combining a washing solution with the hydrolysate in the step S2 to obtain a crude sugar solution; sequentially carrying out adsorption resin decoloration and electrodialysis treatment on the crude sugar solution to obtain a deacidified and desalted sugar solution; purifying the deacidified and desalted sugar solution by ion exchange resin, and concentrating to obtain a xylose product; wherein the adsorption resin is alkalescent anion exchange resin, the electric conductivity of the sugar liquid after electrodialysis treatment is smaller than or equal to 500 microseconds per centimeter, the use of activated carbon is avoided, meanwhile, a neutralizer is not introduced in the whole process, and through the neutralizer-free closed-loop deacidification process, the temperature-controlled hydrolysis process and the resin-membrane coupling purification process, the yield is remarkably increased, and the cost and pollution are reduced.

A compound of Formula I:          R1-L1-C(A)(A') - CH2 - L2-R2     (I) or a pharmaceutically acceptable salt thereof, for use in medicine, for example in the treatment of a disease or condition selected from the group comprising cancer, autistic spectrum disorders, Alzheimer's disease, Parkinson's disease, Huntingdon's disease, muscle wasting and viral infection, wherein: R1 is selected from a carbohydrate group or derivative thereof, hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group; L1 is a linking group; L2 is a linking group; R2 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group; A is selected from hydrogen and a C1-C6 alkyl group; A' is selected from hydrogen, a C1-C6 alkyl group, and L3-R3; wherein L3 is a linking group; and R3 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group; and wherein if A' is not L3-R3, then R2 is a C10-C24 alkyl or a C10-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C10-C24 alkynyl group or a C10-C24 derivative of an alkynyl group; and wherein if A' is L3-R3, then one or both of R2 and R3 are a C10-C24 alkyl or a C10-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C10-C24 alkynyl group or a C10-C24 derivative of an alkynyl group.

This invention discloses a method for preparing a mixture of mussel oligosaccharides and the application of the product in inflammatory bowel disease. This invention uses mussel polysaccharide MP-1 as a raw material, processed by α-amylase or Bacillus subtilis (… Bacillus subtilis BNCC185269) obtained mussel oligosaccharide mixtures MOS-A and MOS-B composed of different oligosaccharides. Animal experiments have shown that the two oligosaccharide mixtures prepared by this invention can effectively alleviate intestinal inflammation. Therefore, the mussel oligosaccharide mixtures prepared by this invention are natural and safe drugs or foods for improving inflammatory bowel disease. They can effectively improve inflammatory bowel disease, are safe, non-toxic, and have no side effects. The raw materials are abundant, the steps are simple, the cost is low, and the effects are significant.