127results about "Monosaccharides" patented technology

The invention provides a method for separating and purifying galactose and glucose by using a simulated moving bed chromatography system, and relates to the technical field of saccharide separation and purification. According to the method, the simulated moving bed chromatography system is used for separating and purifying the galactose, operation can be carried out under the set temperature condition, the separation and purification efficiency of the galactose is remarkably improved, continuous large-scale efficient separation and purification of the galactose can be achieved, the separation and purification effect is good, the yield is high, and the product quality is good. According to the method, pure water is used as an eluent, and analyzed and purified compounds are free of damage, low in toxicity, rich in source and low in cost.

Non-dried allulose crystals are dried in a temperature treating step (b) in a drying apparatus at a temperature of about 25° C. to about 70° C., and in a conditioning step (c). The temperature treating step (b) may be carried out (b1) at atmospheric pressure and a residence time of about 5 minutes to about 5 hours. The temperature treating step (b) may be carried out (b2) under reduced pressure and constant temperature and a residence time from about 40 minutes to about 5 hours. The conditioning step (c) may be carried out (c1) over a period of about 30 minutes to 7 hours at a temperature from about 40° C. to about 70° C. The conditioning step (c) may be carried out (c2) over a period of about 15 minutes to about 90 hours at about 30 to about 60% relative humidity, and a temperature of about 25 to about 40° C.

The invention provides an energy-saving production process of xylose. The energy-saving production process comprises the following steps: crushing corncobs; a hydrolysis step; decolorizing with activated carbon; removing carbon; performing high-pressure membrane concentration; a step of adding calcium for neutralization; a step of over-carbon saturation reaction; ion exchange; performing secondary membrane concentration; carrying out secondary decolorization and interchange; moisture is removed through a triple-effect or higher-effect evaporator, and the sugar degree is increased to 65%; cooling and crystallizing the high-concentration liquid to generate high-purity xylose powder, and drying the xylose powder; warehousing finished products, sealing boxes of the obtained finished products, bagging and entering a warehouse; the energy-saving xylose production process has the advantages that the membrane concentration equipment is introduced into the production process before neutralization, so that the volume of all subsequent liquid is reduced, and the scale of subsequent treatment equipment and the consumption of water are reduced. A large amount of organic acid is removed in the concentration process, occupation of the organic acid on resin is reduced, and the exchange rate is increased; all substances except the organic acid are concentrated, and after the concentration is increased, a large amount of salt is removed through neutralization, so that the treatment content of a subsequent impurity removal procedure is reduced.

This invention discloses an acid-catalyzed controlled degradation and recycling method for waste polyester and polyester-cotton blended fabrics. Using waste polyester or waste polyester-cotton blended fabrics as raw materials, under the action of an acidic catalyst, in a mixed solvent composed of a polar aprotic solvent and water, the method involves heating and degradation, causing the polyester in the waste polyester or polyester-cotton blended fabrics to depolymerize or co-depolymerize, generating organic raw materials. This invention achieves complete depolymerization and recycling of polyester with a relatively low acid dosage, effectively avoiding the corrosion problems of equipment and excessive degradation of cotton fibers caused by existing technologies. It is also more conducive to the generation and recovery of glucose and 5-hydroxymethylfurfural. Furthermore, the separation steps are simple, greatly reducing separation costs, and high-yield recovery of terephthalic acid, glucose, and 5-hydroxymethylfurfural is achieved, realizing high-value recycling and utilization of various components in textiles, reducing waste, and improving resource utilization.

The present invention discloses a method for producing glucosylstevioside using mother sugar and a method for separating and purifying glucosylstevioside to recover glucose, which belongs to the technical field of food additives. [Solution] The present invention provides a method for producing glucosylstevioside using mother liquor sugar, which produces glucosylstevioside using mother liquor sugar as a raw material, thereby enriching the utilization routes of mother liquor sugar and filling the technical gap in the production of glucosylstevioside using mother liquor sugar as a raw material. The produced product also has the advantages of good texture and a high total glycoside content. The present invention provides a method for purifying glucosylstevioside, which recovers and utilizes dextrin, reduces waste liquid discharge, significantly reduces production energy consumption and costs, and improves the yield of high-purity glucosylstevioside. The present invention also provides a method for separating and purifying glucosylstevioside to recover glucose, which is simple and easy to operate, not only produces high-purity glucosylstevioside, but also recovers and utilizes unreacted substrate, thereby reducing costs.

The invention discloses a method for hydrolyzing and saccharifying wood fiber biomass. The method is characterized by comprising the following steps: (1) washing and drying materials; (2) crushing the materials; (3) preparing a material pretreatment solvent; (4) delignification of the material in a pretreatment solvent; (5) filtering the reaction liquid at normal temperature and normal pressure to separate liquid from solid to obtain cellulose; and (6) adding cellulose and polypeptide into deionized water according to a ratio of 2: 1-1: 2 in a solid-to-liquid ratio of 1: 50-1: 100, adding a NaOH solution to adjust the pH value of the solution to 3-8, and reacting at 40-95 DEG C under the protection of nitrogen for 6-16 hours to obtain the product glucose.

The invention discloses an application of a zeolite imidazole framework material in catalysis of a carbon-carbon condensation reaction of formaldehyde. The zeolite imidazole framework material is selected from ZIF-Co / IM, ZIF-Co / 2-MIM, ZIF-Co / 2-EIM, ZIF-Co / 2-PIM, ZIF-Co / 2-BIM, ZIF-Co / 4-MIM, ZIF-Co / dClIM, ZIF-Co / Pur, ZIF-Co / BzIM, ZIF-Co / 2-NIM or ZIF-Zn / 2-MIM. The zeolite imidazole skeleton nano-enzyme material can catalyze formaldehyde FA to generate carbon-carbon condensation so as to generate high value-added saccharide small molecules. Through comparison with a high performance liquid chromatogram of a standard substance, catalytic products are mainly C3 compounds glyceraldehyde (GCA) and dihydroxyacetone (DHA), and a small amount of C4 compounds comprise erythritol, threonose and ketulose. Compared with the traditional formaldehyde enzyme, the formaldehyde enzyme has the advantages of high-concentration substrate tolerance, high-temperature resistance and the like.

The invention discloses a glucose-fructose efficient separation and high-purity fructose preparation method, and belongs to the technical field of monosaccharide purification, the preparation method adopts functional resin as a stationary phase and water as an eluent, and chromatographic separation is carried out at 55-65 DEG C; the method specifically comprises the following steps: S1, filling a chromatographic column with functional resin, and balancing with 55-65 DEG C water; s2, pumping a mixed sugar solution of glucose and fructose into a chromatographic column; s3, eluting with water at 55-65 DEG C, and respectively collecting a glucose fraction and a fructose fraction; and S4, respectively concentrating, crystallizing and drying the glucose fraction and the fructose fraction to obtain a high-purity fructose product. According to the separation method, the purity of the obtained glucose is 94.4%-95.1%, the recovery rate of the glucose is 97.1%-98.0%, the purity of the obtained fructose is 98.6%-99.2%, and the recovery rate of the obtained fructose is 95.5%-96.8%.

This disclosure relates to a product, a beverage product, and an infusion formulation that each include at least two rare sugars, for example allulose and tagatose. The combination of allulose and tagatose synergistically sweeten the product, beverage product, and infusion formulation. The product includes a food body having a food component and an infusion component. The infusion component includes at least two rare sugars. The beverage product includes a consumable liquid and at least two rare sugars. This disclosure further relates to methods for preparing a food product and beverage product.

The application belongs to the technical field of medicine production, and particularly relates to a preparation method and application of five deuterium-substituted glucose. The method comprises deuterium substitution of D-methyl glucoside, and demethylation of the deuterium-substituted D-methyl glucoside to obtain a target product, namely [2,3,4,6,6'-d5]-D-glucose. The preparation method of the five deuterium-substituted glucose is simple in process route, convenient to operate, mild in experimental conditions, and the synthesized five deuterium-substituted glucose is successfully applied to the description of glycolysis metabolism in a brain glioma model, which is helpful to the clinical conversion application of metabolic imaging technology.

Compositions of de-acylated carbohydrate compounds and methods of making them are provided. The methods can be designed to produce the desired products under conditions of moderate temperature, moderate pH, and without the use of harsh solvents.

The invention discloses a preparation technology of astragalus polysaccharide camouflage monosaccharide, and relates to the technical field of biological product production, the preparation technology comprises the following steps: S1, extraction, S2, purification: carrying out purification treatment on astragalus polysaccharide extracted in the step 1, S3, degradation camouflage: dissolving the astragalus polysaccharide purified in the step 2 in a solvent, carrying out degradation treatment on the astragalus polysaccharide by adopting ultrasonic waves, and carrying out purification treatment on the astragalus polysaccharide to obtain the astragalus polysaccharide camouflage monosaccharide. A specific glucan structural unit in a polysaccharide chain is degraded and disguised into a monosaccharide or oligosaccharide structure; and S4, separating to obtain a product. Astragalus polysaccharide is directionally camouflaged as a monosaccharide / oligosaccharide structure, the recognition and uptake efficiency of astragalus polysaccharide by cancer cells is remarkably enhanced, so that the targeting of inducing apoptosis of cancer cells is improved, the structure can effectively activate and train immune cells such as dendritic cells and strengthen anti-tumor immune response, and meanwhile, the product can interfere with a metabolic pathway of cancer cells and reverse the drug resistance of cancer cells, so that the anti-tumor effect is improved. Nutrition supply is blocked to inhibit tumor growth, the production process is green and controllable, and good clinical transformation and industrialization prospects are achieved.

Various processes for preparing C4 aldoses and / or ketones thereof are described. Various processes are described for preparing C4 aldoses and / or ketones thereof from feed compositions comprising glycolaldehyde. Also, various processes for preparing useful downstream products and intermediates, such as erythritol and erythronic acid, from the C4 aldoses and / or ketones thereof are described.

The invention discloses a preparation method of (a / b)-D-fucose and fucose tetraacetate, and belongs to the technical field of organic synthesis. The preparation method of the (a / b)-D-fucose and fucose tetraacetate is based on a PPh3 / NBS method, the PPh3 / NBS combination is a method for efficiently, highly selectively and mildly converting primary alcohol and secondary alcohol into corresponding alkyl bromide, and the core of the method is to generate Ph3PBr2 to activate hydroxyl. In the whole process, reaction conditions are mild, treatment is simple, needed drugs are cheap and easy to obtain, most of intermediate products are synthesized through a one-pot method, few intermediate products need to be separated and purified through silica gel column chromatography, the operation time of follow-up experimental treatment and separation and purification is omitted, and the time of the whole reaction process is greatly shortened. In addition, due to the fact that repeated purification is not needed, the final yield is guaranteed, the total yield can reach 17%, and the gram level can be reached at a time.

This invention discloses an alloy catalyst, comprising a support and a copper-ruthenium alloy supported on the support, wherein the copper-ruthenium alloy is: Cu 0.7 Ru 0.3 The alloy catalyst prepared by this invention can be used to prepare cyclopentanone. The catalyst has high activity, good stability, and low price. The reactants used in the reaction are renewable, widely distributed, and inexpensive. The preparation of cyclopentanone using the catalyst of this invention does not require the introduction of acid or alkali, which solves the problem of difficult acid treatment in the prior art. Furthermore, it is not corrosive to the reaction equipment, which is conducive to large-scale production.

The present application relates to a method for preparing crystalline D-psicose. In the present application, crystalline D-psicose is prepared by means of combining an evaporative crystallization method and a cooling crystallization method, so that the preparation process is simple, the operation is easy, and the crystallization period is short. In the present application, a seed crystal is added when the solid content is relatively low (70-75%) in an evaporative crystallization process, so that the crystallization process is facilitated, the growth speed of the crystal in each direction is more uniform, the whole crystallization period can be shortened, and the energy consumption is reduced; and after the evaporative crystallization is finished, crystal regulation is carried out, so that the crystal size tends to be equalized, the crystal surface grows to be smooth, and the crystal form is perfected. Cooling crystallization is carried out after the crystal regulation, and the cooling frequency of specific cooling intervals is designed in the cooling process according to the metastable region curve of D-psicose. After crystallization by means of the preparation method of the present application is finished, the obtained crystal has a high yield, a narrow crystal size distribution, a smooth crystal surface, a mirror-like surface, good reflectivity and a regular crystal form.

A compound of Formula I:          R1-L1-C(A)(A') - CH2 - L2-R2     (I) or a pharmaceutically acceptable salt thereof, for use in medicine, for example in the treatment of a disease or condition selected from the group comprising cancer, autistic spectrum disorders, Alzheimer's disease, Parkinson's disease, Huntingdon's disease, muscle wasting and viral infection, wherein: R1 is selected from a carbohydrate group or derivative thereof, hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group; L1 is a linking group; L2 is a linking group; R2 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group; A is selected from hydrogen and a C1-C6 alkyl group; A' is selected from hydrogen, a C1-C6 alkyl group, and L3-R3; wherein L3 is a linking group; and R3 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group; and wherein if A' is not L3-R3, then R2 is a C10-C24 alkyl or a C10-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C10-C24 alkynyl group or a C10-C24 derivative of an alkynyl group; and wherein if A' is L3-R3, then one or both of R2 and R3 are a C10-C24 alkyl or a C10-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C10-C24 alkynyl group or a C10-C24 derivative of an alkynyl group.

This invention discloses a method for preparing a mixture of mussel oligosaccharides and the application of the product in inflammatory bowel disease. This invention uses mussel polysaccharide MP-1 as a raw material, processed by α-amylase or Bacillus subtilis (… Bacillus subtilis BNCC185269) obtained mussel oligosaccharide mixtures MOS-A and MOS-B composed of different oligosaccharides. Animal experiments have shown that the two oligosaccharide mixtures prepared by this invention can effectively alleviate intestinal inflammation. Therefore, the mussel oligosaccharide mixtures prepared by this invention are natural and safe drugs or foods for improving inflammatory bowel disease. They can effectively improve inflammatory bowel disease, are safe, non-toxic, and have no side effects. The raw materials are abundant, the steps are simple, the cost is low, and the effects are significant.

The invention provides a purification method for efficiently producing fucose by using genetically engineered bacteria, the preservation number of the genetically engineered bacteria is CCTCC NO: M 20252837, fermentation liquor of the genetically engineered bacteria is purified, and the purification method comprises the following specific steps: S1, taking the fermentation liquor, and filtering by using a ceramic membrane to obtain filtrate I; s2, adding a decolorizing agent into the filtrate I, stirring and decolorizing, and filtering through a filtering membrane to obtain filtrate II; s3, performing ultrafiltration on the filtrate II, performing top washing with pure water, and collecting all filtrate to obtain filtrate III; s4, sequentially carrying out cationic resin and anion resin combined chromatography on the filtrate III to obtain a chromatographic solution; s5, performing electrodialysis desalination on the chromatographic solution until the conductivity is 1t; the concentration is 100 [mu] s / cm; s6, concentrating the desalted solution, adding absolute ethyl alcohol, firstly heating and stirring, and then cooling until stirring, so as to obtain a turbid liquid; s7, the turbid liquid is filtered, solid is eluted with absolute ethyl alcohol, vacuum drying is conducted, and fucose is obtained. The purification method provided by the invention has the advantages of high purity, high yield and short period, and is suitable for industrial production.

To provide methods for treating cellulosic biomass to produce cellulosic sugars, and products thereof.SOLUTION: A two-step method for activating cellulosic feedstock is described. The feedstock is subjected to a first high-temperature activation step at a temperature above 190°C. and a second activation step at a lower temperature under alkaline conditions. Also described are methods and compositions for the enzymatic hydrolysis of activated cellulose using one or more cellulase enzymes, a surfactant and polyaspartic acid. Also described are products of the methods.SELECTED DRAWING: None

The present application relates to the technical field of biomass catalytic conversion, in particular to a beta molecular sieve supported tin-based catalyst, a preparation method and application thereof, and a method for continuously catalyzing glucose to prepare fructose. The preparation method of the beta molecular sieve supported tin-based catalyst comprises the following steps: 1) acid modification treatment: mixing the beta molecular sieve with an acid solution, heat treatment, washing, drying, calcination, and obtaining modified beta molecular sieve; 2) loading of active components: mixing a tin salt with the modified beta molecular sieve in step 1) in the presence of an organic solvent, standing, drying, calcination, and obtaining the beta molecular sieve supported tin-based catalyst after cooling; wherein the loading amount of tin oxide in the beta molecular sieve supported tin-based catalyst is 10-50 wt%. The beta molecular sieve supported tin-based catalyst has the characteristics of high catalytic activity, good selectivity, uniform dispersion of active components, stable structure, etc., and can realize efficient continuous isomerization conversion of glucose in a methanol-water mixed reaction medium, significantly improving the yield of fructose.

The invention relates to the technical field of membrane separation, in particular to a treatment method of xylose / glucose hydrolysate. The invention provides a xylose / glucose hydrolysate treatment method, which comprises: sequentially carrying out pretreatment and membrane deacidification concentration on a xylose / glucose hydrolysate to obtain a xylose / glucose concentrated liquid and a membrane deacidification concentration system filtrate; carrying out organic acid and inorganic acid separation on the filtrate of the membrane deacidification concentration system to obtain an inorganic acid concentrated solution and an organic acid permeable solution; and carrying out reverse osmosis treatment on the organic acid permeable liquid to obtain an organic acid salt concentrated liquid and pure water. The method provided by the invention has the advantages of high recycling rate of xylose / glucose and low cost.

The invention belongs to the technical field of microorganisms, and particularly relates to a microvesicle bacterium capable of degrading sargassum horneri and application of the microvesicle bacterium. The microvesicles are microvesicles okinawensis, the microvesicles are preserved in the China General Microbiological Culture Collection Center on October 27, 2025, and the preservation number of the microvesicles is CGMCC (China General Microbiological Culture Collection Center) No. 36355. The microvesicle bacterium of the sargassum horneri component degrading enzyme is screened from rotten sargassum horneri, cell walls of the sargassum horneri can be efficiently cracked, release of effective components in brown algae is promoted, and therefore utilization of sargassum horneri resources is promoted.

The present invention provides allulose crystal particles exhibiting a particle size distribution in which 80-95 wt% of the total crystal particles have a size of 300 μm or greater and 0.1-5 wt% have a size of less than 212 μm, and having an average aspect ratio (the ratio of major axis length to minor axis length) of 1 to 3 and an average particle size of 400-520 μm. The allulose crystal particles according to the present invention exhibit low hygroscopicity and high anti-caking properties. Accordingly, the allulose crystal particles of the present invention can be stored and distributed for extended periods without degradation in quality.

Provided herein are compositions and methods related to improved production of psicose by converting fructose to psicose using a psicose from Brachyspira suanatina, or a psicose-3-epimerase enzyme, in the presence of 50 or 100 mg / L of an alkali NaOH, and methods related to improved production of psicose by using a psicose from Brachyspira suanatina, or a psicose-3-epimerase enzyme from Brachyspira suanatina, or a psicose-3-epimerase enzyme from Brachyspira suanatina, or a psicose-3-epimerase enzyme from Brachyspira suanatina or a psicose-3-epimerase.

The invention belongs to the technical field of preparation of galactitol, and particularly relates to a method for preparing galactitol by taking lactose as a raw material. Comprising the following steps: S1, preparation of an adsorption column: preparing phenylboronic acid polymer microspheres and packing the microspheres into a column to obtain the adsorption column; s2, enzymolysis: carrying out enzymolysis on the lactose solution through lactase to obtain enzymatic hydrolysate; s3, monosaccharide separation: filtering the enzymatic hydrolysate, adjusting the pH value to be alkaline, passing through an adsorption column to obtain a glucose-rich solution, and enabling an eluent to flow through the adsorption column to obtain a galactose-rich solution; and S4, hydrogenation: carrying out ion exchange, concentration, hydrogenation, decoloration, ion exchange, concentration and crystallization on the galactose pregnant solution to obtain galactitol. According to the invention, galactose with a cis-vicinal diol structure can be adsorbed by the phenylboronic acid polymer carrier, so that glucose and galactose which are difficult to separate by chromatographic separation are separated, and a production process for preparing galactitol by taking lactose as a raw material is realized.

The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, capable of inhibiting Apolipoprotein C-III (also called APOC3, apoC-III, APOC-III, and APO C-III) gene expression, and compositions that include APOC3 RNAi agents. The APOC3 RNAi agents disclosed herein may be conjugated to targeting ligands, including ligands that include N-acetyl-galactosamine, to facilitate the delivery to cells, including to hepatocytes. Pharmaceutical compositions that include one or more APOC3 RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the APOC3 RNAi agents in vivo provides for inhibition of APOC3 gene expression, and can result in lower triglycerides and / or cholesterol levels in the subject. The APOC3 RNAi agents can be used in methods of treatment of APOC3-related diseases and disorders, including hypertriglyceridemia, cardiovascular disease, and other metabolic-related disorders and diseases.

Provided herein are compositions and methods relating to improved production of allulose by converting fructose to allulose using a allulose or psicose-3-epimerase from Brachyspira suanatina in the presence of base NaOH at 50 or 100mg / L.

Psicose crystals are efficiently prepared from a psicose syrup using a seed crystal.