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High-pressure water vapor degradation method for marine sulfated polysaccharides

A sulfuric acid polysaccharide and water vapor technology, which is applied in the field of degradation of polysaccharide compounds, can solve the problems of high cost, poor reaction regularity, and product yield decline, and achieve low equipment requirements, good reproducibility, and stable methods Effect

Active Publication Date: 2011-04-27
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reaction regularity of the acid hydrolysis method and the oxidative degradation method is poor, the process is difficult to control, and the reproducibility is not good; the reaction environment is non-neutral, and a large amount of inorganic salts are introduced after the reaction is completed and neutralized, and subsequent steps of desalination are required, resulting in a decrease in product yield and production. Increased costs
Enzymatic hydrolysis is the use of corresponding glycosidases to degrade polysaccharides. Its reaction is strong and reproducible, and it is an ideal method for polysaccharide degradation. However, only a few types of marine sulfated polysaccharides can be enzymatically hydrolyzed, and the cost is high. Difficult to apply to mass production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Dissolve 10g of Haitian ginseng chondroitin sulfate in 1990g of distilled water to prepare a 0.5% (mass percentage, the same below) aqueous solution, place it in a high-pressure steam boiler, and treat it with high-pressure steam at 126°C for 30min, 60min, 120min, 180min, 240min, 300min, 360min, 420min or 480min, and then freeze-dried to obtain the degradation product of chondroitin sulfate from sea sweet potato ginseng. 4.76kDa, 2.68kDa, 1.15kDa.

[0011] The concentration of the polysaccharide described in this embodiment can be 0.01%-20%, the temperature of high-pressure steam can be 101°C-150°C, the processing time can be 0.01-24hr, and the drying can be hot air drying or spray drying.

Embodiment 2

[0013] Dissolve 10g of Haitian melon ginseng fucoidan sulfate in 1990g of distilled water to prepare a 0.5% aqueous solution, place it in a high-pressure steam boiler, and treat it with high-pressure steam at 126°C for 30min, 60min, 120min, 180min, 240min, 300min, 360min, 420min or 480min, and then freeze-dried to obtain the degradation products of fucoidan sulfate from Haitian melon ginseng, the molecular weight of which was reduced from the initial 2340kDa to 373kDa, 262kDa, 260kDa, 60.9kDa, 34.6kDa, 21.0kDa, 17.7kDa, 12.9kDa, 10.6 kDa.

[0014] The concentration of the polysaccharide described in this embodiment can be 0.01%-20%, the temperature of high-pressure steam can be 101°C-150°C, the processing time can be 0.01-24hr, and the drying can be hot air drying or spray drying.

Embodiment 3

[0016] Dissolve 10g of kelp fucoidan sulfate in 1990g of distilled water to prepare a 0.5% aqueous solution, place it in a high-pressure steam pot, and treat it with high-pressure steam at 126°C for 0min, 30min, 60min, 120min, 180min, 240min, 300min, 360min, 420min or 480min, after freeze-drying, the degradation products of kelp fucoidan sulfate were obtained, and the molecular weight was reduced from the initial 258kDa to 82.4kDa, 18.7kDa, 16.8kDa, 3.89kDa, 1.95kDa, 1.36kDa, 1.31kDa, 1.23kDa and 1.21kDa.

[0017] The concentration of the polysaccharide described in this example can be 0.01%-20%, the temperature of high-pressure water vapor can be 101°C-150°C, the processing time can be 0.01-24hr, and the drying can be hot air drying, spray drying or other drying methods .

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Abstract

The invention relates to a high-pressure water vapor degradation method for marine sulfated polysaccharides. The method is characterized in that the marine sulfated polysaccharides are prepared into water solution, then the water solution is treated by high-pressure water vapor at the temperature of 101-150 DEG C for 0.01-24hours, and the obtained treatment solution is dried for obtaining degraded products of the polysaccharides. The marine sulfated polysaccharides comprise seaweed fucoidan, carrageenan and agaropectin which are sourced from marine plants, as well as sea cucumber chondroitin sulfate, sea cucumber fucoidan and abalone sulfated polysaccharides, which are sourced from marine animals. The method has the advantages that no inorganic salt is introduced, and the final products can be obtained by drying after degradation without desalinization; the molecular weight of the polysaccharides can be reduced continuously and uniformly, and the degraded products with different molecular weight can be obtained by controlling the treatment conditions and the treatment time; the method is stable, and the reproducibility is good; and the requirement on equipment is low, and the operation is simple.

Description

technical field [0001] The invention relates to a degradation method of polysaccharide compounds, in particular to a high-pressure steam degradation method of marine sulfated polysaccharides. Background technique [0002] The sulfated polysaccharides contained in marine animals and plants, such as seaweed fucoidan sulfate, carrageenan, sulfur agar, sea cucumber chondroitin sulfate, sea cucumber fucoidan sulfate and abalone sulfate polysaccharides, are rich in sulfate radicals, which have been confirmed It has various physiological activities such as anti-coagulation, anti-tumor, anti-virus, anti-inflammation, regulating blood lipid and improving immunity. Marine sulfated polysaccharides have shown good application prospects in the development of functional foods and new drugs, and have become a hot spot in the field of polysaccharide compound research. [0003] Polysaccharide degradation products are good tools for studying the structure and structure-activity relationship ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08C08B37/00
Inventor 常耀光薛长湖王彦超武晓琳徐杰王静凤
Owner OCEAN UNIV OF CHINA
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