22 results about "Fluoroacetamide" patented technology

The invention relates to a method for detecting primary metabolites and / or secondary metabolites in flavors and fragrances, which comprises the following steps: (1) mixing flavors and fragrances, an internal standard substance and a solvent, extracting, taking clear liquid, and removing the solvent to obtain a dry product; (2) mixing the dry product, an oximation reagent and a solvent for an oximation reaction, and then mixing a reaction system and a silanization reagent for a silanization reaction to obtain a solution to be detected; the silanization reagent comprises a combination of N-methyl-N-(trimethylsilyl) trifluoroacetamide and N, O-bis (trimethylsilyl) trifluoroacetamide, and the silanization reagent comprises N-methyl-N-(trimethylsilyl) trifluoroacetamide and N, O-bis (trimethylsilyl) trifluoroacetamide; and (3) detecting the solution to be detected by adopting a gas chromatography-mass spectrometry method, and obtaining the content of primary metabolites and / or secondary metabolites in the flavors and fragrances by utilizing an internal standard method. According to the method provided by the invention, the flavors and fragrances are subjected to oximation and silanization treatment, and then the flavors and fragrances are detected by using the gas chromatography-mass spectrometry, so that the metabolites contained in the flavors and fragrances can be precisely and accurately detected.

The invention discloses a polymer solid electrolyte membrane and application thereof. The polymer solid electrolyte membrane is prepared from 5-15 parts by mass of a polymer, 4-10 parts by mass of a lithium salt, 3-6 parts by mass of a material for constructing a lithium-loving and lithium-phobic layer, 0.5-1.5 parts by mass of a plasticizer and 30-50 parts by mass of a solvent. And the material for constructing the lithium-loving and lithium-phobic layer is one of N-methyl-2, 2, 2-trifluoroacetamide, zinc bis (trifluoromethanesulfonamide) and silver bis (trifluoromethanesulfonamide), and one of zinc fluoride and silver fluoride, and the material for constructing the lithium-loving and lithium-phobic layer is one of N-methyl-2, 2, 2-trifluoroacetamide, zinc bis (trifluoromethanesulfonamide) and silver bis (trifluoromethanesulfonamide). The lithium-loving and lithium-phobic layer is synchronously constructed on the surface of the lithium metal negative electrode, uniform deposition of lithium metal is promoted, growth of lithium dendrites is inhibited, contact between the lithium metal negative electrode and a solid electrolyte interface is improved through uniform generation of the SEI layer, and the cycling stability and safety of the lithium metal negative electrode are remarkably improved.

The invention discloses an amide electrolyte, a preparation method and a sodium battery, and belongs to the technical field of battery electrolytes. The amide electrolyte comprises a sodium salt and a composite solvent, the composite solvent comprises fluoroethylene carbonate and an amide solvent, the volume ratio of the fluoroethylene carbonate to the amide solvent is 1: 4, and the molar concentration of the sodium salt is 1M. The amide solvent is one of N, N-diethyl acetamide, N, N-diethyl-2, 2, 2-trifluoroacetamide, N, N-dimethyl trifluoroacetamide and N-methoxy-N-methyl-2, 2, 2-trifluoroacetamide, and the solvent is one of N, N-diethyl acetamide, N, N-diethyl-2, 2, 2-trifluoroacetamide, N, N-dimethyl trifluoroacetamide and N-methoxy-N-methyl-2, 2, 2-trifluoroacetamide. By adopting the amide electrolyte, the preparation method and the sodium battery, the problems that an existing sodium battery is poor in reversibility and cycling stability and poor in cycling performance and rate capability under high voltage can be solved.

The invention relates to the field of organic synthesis, in particular to a method for continuously preparing 5-(trifluoromethyl)-1H-tetrazole sodium salt. The method comprises the following steps: mixing trifluoroacetamide and 3-methylpyridine to obtain a mixture I; phosphorus oxychloride and 3-methylpyridine are mixed, and a second mixture is obtained; a continuous feeding mode is adopted, the first mixture and the second mixture are mixed, a steady-state reaction is maintained, and reaction liquid is continuously obtained; performing gas-liquid separation on the reaction liquid to obtain liquid and gas, quenching the liquid, performing gas washing on the gas through 3-methylpyridine, then introducing the gas into a mixed solution of sodium azide and acetone for absorption and filtration to obtain a filter cake, and performing drip washing to obtain the 5-(trifluoromethyl)-1H-tetrazole sodium salt. The purity of the product prepared by the method is greater than or equal to 99.3%, the yield is 84-91%, and the method is easy for industrial production.

The application belongs to the technical field of bioactive substance preparation and agricultural application, and discloses a beta-amino butyric acid, a whole cell conversion preparation method thereof and application thereof. The method uses Paenibacillus halophilus as a catalyst to perform biological conversion in a reaction system containing a substrate, so as to obtain the beta-amino butyric acid. The method has mild reaction conditions, the bacterial cells can be repeatedly used, the conversion rate is high, and the green, efficient and low-cost production of the beta-amino butyric acid is realized. The application also provides application of the beta-amino butyric acid prepared by the above method in improving salt stress resistance of crops and in plant disease control as a pesticide synergist. Experiments show that the beta-amino butyric acid can significantly alleviate the inhibition of salt stress on the growth of wheat, and improve the chlorophyll content and biomass accumulation; the beta-amino butyric acid has a synergistic effect on grape diseases when used in combination with anilazodifen and fluoroacetamide, and meanwhile, the fruit quality and storage resistance are improved.

The utility model discloses a trifluoroacetamide drying device, which belongs to the technical field of chemical product drying equipment and comprises an operation table for supporting trifluoroacetamide drying, a drying protection barrel is mounted at the top of the operation table, a transverse rod is welded on the vertical inner wall of the drying protection barrel, a sliding groove is formed in the transverse rod, and a sliding groove is formed in the sliding groove. Two springs are symmetrically connected into the sliding groove, the ends of the two springs are connected with a moving plate, the top of the moving plate is connected with a connecting block, a moving disc is welded to the end, away from the moving plate, of the connecting block, a motor is installed at the top of the moving disc, and an output shaft of the motor is connected with a connecting column through a coupler. According to the trifluoroacetamide screening device, the screening capacity is improved, trifluoroacetamide powder with different particle sizes can be effectively separated out, the particle sizes are more uniform, the production efficiency is improved, and the reject ratio of products is reduced.

The invention discloses an electrolyte of a high-specific-capacity lithium-carbon fluoride battery as well as a preparation method and application of the electrolyte. The electrolyte comprises double lithium salts and a multi-component solvent, the double lithium salt is lithium tetrafluoroborate (LiBF) and lithium bis (fluorosulfonyl) imide (LiFSI); the multi-component solvent contains tetrahydrofuran (THF) and 1, 3-dioxolane (DOL), comprises at least one of methyl acetate (MA), N, N-diethyl-2, 2, 2-trifluoroacetamide (DMTFA), ethylene carbonate (EC) and m-fluorotoluene (m-FT), and does not contain MA and DMTFA at the same time; through the combination design of the differentiated lithium salt and the multi-component solvent, the specific discharge capacity of the battery at normal temperature and low temperature is improved, the synergistic requirements of a wide temperature range, high interface stability and high safety are met, and the electrolyte keeps efficient operation within the wide temperature range.

This invention relates to a high-efficiency release and corrosion-resistant powder coating for concrete formwork, belonging to the field of coating technology. Based on the property that dopamine self-polymerizes to form polydopamine under alkaline and aerobic conditions, this invention allows for the organic self-polymerization and coating of nano-silica. A certain amount of zinc chloride solution is then added, utilizing the catechol structure of polydopamine to chelate zinc ions. Finally, the coating is modified with a modifier formed by the interaction of hydroxyl groups and -NCO groups of propyl isocyanate-3-(triethoxysilyl)propyl and N-(2-hydroxyethyl)trifluoroacetamide, grafting carbon-fluorine bonds to prepare a modified filler. When mixed with other components, the resulting powder coating, when applied to concrete formwork, not only imparts excellent corrosion resistance, making it less susceptible to concrete erosion, but also exhibits good wear resistance, low surface energy, hydrophobicity, and easy release properties, and the coating remains undamaged even after repeated use.

The application is a production method and equipment of trifluoroacetamide, and relates to the technical field of trifluoroacetamide production equipment, comprising a rack, a premixing box body on the top of the rack is provided with a feeding mechanism, a premixing inner cavity is arranged in the premixing box body, four cavity partition plates are fixedly installed on the outer wall of the central shaft in the premixing inner cavity, and the premixing inner cavity is divided into four equal-volume distribution cavities; an annular seat is arranged on the outer side of the premixing box body, one end of the central shaft is arranged in the inner part of the annular seat and rotationally matched with the annular seat, the other end of the central shaft is fixedly connected with a power driving shaft, a driving mechanism is installed on the outer end part of the power driving shaft, and the driving mechanism is used for intermittently rotating the power driving shaft by 90 degrees. The application can complete the premixing operation of four different molar ratio formulas in parallel, not only greatly improves the equipment utilization and production efficiency, but also gives the production line strong flexible output capacity and can quickly respond to the production demand of trifluoroacetamide products with different purity grades.

The invention discloses a method for preparing a difluoroalkylated polycyclic coumarin derivative (I) under a visible light condition, and belongs to the technical field of organic synthesis. According to the method, 4-(N-alkyl-N-acrylamide) coumarin and a brominated difluoroacetamide compound are taken as reaction raw materials under the condition of visible light irradiation, in the presence of an oxidizing agent and alkali, a reaction is performed in an organic solvent or a mixed solvent of the organic solvent and water, and the difluoroalkylated polycyclic coumarin derivative is obtained through post-treatment. The method does not need a metal or non-metal photocatalyst, is mild in reaction condition and simple and convenient to operate, has good regioselectivity and higher yield, is suitable for various substituted substrates, and has potential application value in the fields of medicines, chemical engineering, materials and the like.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to trifluoroacetamide as well as a synthesis method and a synthesis device thereof. The synthesis method of trifluoroacetamide comprises the following steps: mixing trifluoroacetyl chloride and ammonia gas in an organic solvent, controlling the temperature and the flow rate, after the reaction is finished, separating to obtain a byproduct ammonium chloride and a reaction solution, carrying out reduced pressure distillation on the reaction solution, continuing to heat and dissolve the residual crude product in a ternary solvent, and then carrying out gradient cooling crystallization, separation, washing and drying to obtain the trifluoroacetamide. The pure product trifluoroacetamide is obtained. The synthesis method of trifluoroacetamide provided by the invention has the advantages of few side reactions, no corrosion risk and simple operation, and the synthesized trifluoroacetamide has high purity and high yield; the invention also provides a synthesis device of trifluoroacetamide.

This invention discloses a method for simultaneously and accurately determining the content of multiple biogenic amines in baijiu (Chinese liquor). Based on gas chromatography-triple quadrupole mass spectrometry (GC-MS), it detects multiple biogenic amines in baijiu, including nicotinamide, β-phenylethylamine, guanidine, and putrescine. In the pretreatment process, 1,7-diaminoheptane is added as an internal standard, and a mixture of N,O-bis(trimethylsilyl)trifluoroacetamide and trimethylchlorosilane is used as a derivatization reagent, effectively simplifying the pretreatment process. By controlling the conditions of GC and MS, accurate, rapid, and highly sensitive determination of multiple biogenic amines in baijiu is achieved. In this invention, baijiu samples do not require extraction with organic solvents or pH adjustment; the pretreatment operation is extremely simple, and the sensitivity and quantitative accuracy of biogenic amines are high, with good stability and reliability. This effectively improves the problem of complex pretreatment operations and poor detection accuracy in the quantitative determination of biogenic amines in baijiu.

The invention relates to a trifluoroacetamide production method and equipment, and relates to the technical field of trifluoroacetamide production equipment.The trifluoroacetamide production equipment comprises a rack, a feeding mechanism is arranged at the top of a premixing box on the rack, a premixing inner cavity is formed in the premixing box, and four cavity partition plates are fixedly installed on the outer wall of a center shaft in the premixing inner cavity; the premixing inner cavity is divided into four equal-volume material distribution cavities; a shaft ring seat is arranged on the outer side of the premixing box body, one end of the central shaft is arranged in the shaft ring seat and is in running fit with the shaft ring seat, the other end of the central shaft is fixedly connected with a power driving shaft, and a driving mechanism is mounted at the outer end part of the power driving shaft and is used for enabling the power driving shaft to intermittently rotate by 90 degrees. According to the invention, premixing operation of four formulas with different molar ratios can be completed in parallel, so that the equipment utilization rate and the production efficiency are greatly improved, a production line is endowed with relatively strong flexible output capability, and the production requirements of trifluoroacetamide products with different purity grades can be quickly responded.

The utility model relates to a preparation device of trifluoroacetamide. The preparation device comprises a reaction tank and a cooling assembly, the cooling assembly comprises a cylindrical body composed of a first ring body, a second ring body and a plurality of hollow fin plates. The first ring body is fixedly arranged at the upper port of the reaction tank. A first annular cavity is formed in the first ring body, a first inserting opening communicated with the first annular cavity is formed in the side wall of the first ring body, and a medium feeding pipe is connected with the first inserting opening. The second ring body is fixedly arranged at the lower part of the tank cavity of the reaction tank. A second annular cavity is formed in the second ring body, a second inserting opening communicated with the second annular cavity is formed in the side wall of the second ring body, and the medium discharging pipe is connected with the second inserting opening. The fin plates are distributed at intervals in the circumferential direction and arranged in the vertical direction, so that the upper ends of the fin plates communicate with the first annular cavity, and the lower ends of the fin plates communicate with the second annular cavity. The device has the advantages of being convenient and fast to assemble and disassemble, reducing the difficulty of scale cleaning, improving the working efficiency and reducing the operation loss.

The application discloses a preparation method of trifluoroacetamidine, and belongs to the field of drug chemical synthesis, and specifically, trifluoroacetamide is used as raw material, gaseous trifluoroacetonitrile is generated by dehydrating the trifluoroacetamide in the presence of an organic base pyridine, then the gaseous trifluoroacetonitrile is directly introduced into an organic solution of ammonia to react with the organic solution of ammonia to generate a trifluoroacetamidine solution. The pyridine plus phosphorus oxychloride system is used to prepare trifluoroacetonitrile gas, and the organic solution of ammonia is used to absorb the trifluoroacetonitrile gas, so that the problems of low safety, high cost, serious environmental pollution and low yield in the previous process are solved.

The invention belongs to the field of fine chemical engineering, and discloses a preparation method of fluoroacetonitrile, which comprises the following steps: step 1, taking ethyl fluoroacetate and ammonia water as raw materials to react to prepare fluoroacetamide; 2, carrying out a dehydration reaction on fluoroacetamide to prepare fluoroacetonitrile; according to the method, ethyl fluoroacetate and ammonia water are adopted as raw materials to react to prepare an intermediate product fluoroacetamide, then the intermediate product is dehydrated, fluoroacetonitrile can be prepared, the process route is simple, and the reaction is easy to carry out; according to the method, highly toxic raw materials or intermediate products are not involved, the raw material ethyl fluoroacetate is cheap and easy to obtain, the purity of the product can reach 99.99%, and the yield can reach 90% or above.

The application discloses a method for determining prothioconazole and chlorothalonil in plant source food, which comprises the following steps: S1, preparing a sample to be measured, diluting or dissolving the sample with water, high-speed centrifugation, and taking supernatant; S2, purifying the sample to be measured, using a mixed cation exchange solid phase extraction purification column, washing the column with water, vacuum drying, and then eluting with methanol; S3, derivative of the sample to be measured, adding O-bistrimethylsilyl trifluoroacetamide + trimethylchlorosilane; S4, purification of the derivative, adding saturated sodium chloride solution, and taking the lower dichloromethane layer; S5, detecting the sample to be measured, feeding the derivative sample solution and standard working solution into a gas chromatography-tandem mass spectrometer, taking the concentration of the pesticide derivative in the standard solution as the abscissa, the peak area of the quantitative ion pair as the ordinate, drawing a working curve, and quantifying by an external standard method. The application can check the plant source food, improve the safety of the plant source food circulating on the market, and guarantee food safety standards.

The invention discloses a preparation method of a 2-piperidone derivative, which comprises the following steps: reacting brominated difluoroacetamide, arylboronic acid, bis (triphenylphosphine) nickel dichloride, 3, 4, 7, 8-tetramethyl-1, 10-phenanthroline, formic acid, acetic anhydride and sodium carbonate at 90 DEG C for 16 hours, and after the reaction is completed, performing post-treatment to obtain the 2-piperidone derivative. According to the preparation method, bromo-difluoroacetamide and arylboronic acid are used as reactants, formic acid is used as a carbonyl source, reaction conditions are mild, operation is easy, the tolerance range of substrate functional groups is wide, and reaction efficiency is high. Various 2-piperidone derivatives can be synthesized according to actual needs, and the practicability of the method is widened while the operation is convenient.

This invention relates to the field of organic synthesis, specifically to a method for the preparation of difluoroenones and their in-situ reaction with amines, alcohols, etc., to convert them into the corresponding difluoroacetamides and difluoroacetic acid esters. The invention involves sequentially adding potassium fluoride, an amine or alcohol, and a difluorobromoacrylsilyl compound to a reaction solvent under a nitrogen atmosphere to obtain a mixture. This mixture is stirred at 25°C until the reaction is complete, filtered, and purified to obtain the difluoroacetamide or difluoroacetic acid ester compound. The preparation method of this invention is simple to operate (highly reactive difluoroenones are generated in situ and participate in the reaction), achieving efficient synthesis of difluoroacetamide / difluoroacetic acid esters and avoiding the use of highly volatile difluoroacetyl chloride. The difluorobromoacrylsilyl used in this invention can be conveniently prepared on a large scale and can be purified by distillation. The reaction conditions involved in the preparation method of this invention have good substrate tolerance and can be applied to aliphatic amines, aromatic amines, and various primary and secondary alcohols.

The application relates to a preparation method of a monolithic catalyst for catalytic combustion of methane, which comprises the following steps: impregnating a honeycomb carrier in a titanium dioxide sol, taking out and drying and roasting to obtain a carrier with a TiO2 coating; impregnating the carrier with the TiO2 coating in an active metal salt solution, wherein 3-(trifluoroacetamido) pyrrolidine hydrochloride is added in the active metal salt solution, the active metal is a perovskite type metal composite oxide, and the general structure is ABO3; taking out, drying and roasting to obtain the monolithic catalyst. 90 The monolithic catalyst provided by the application is used for catalytic combustion of methane, has a low-temperature catalytic activity of less than 500 DEG C, and has the advantages of high low-temperature catalytic activity and good long-term use activity.