The invention discloses an industrial production method for pigment yellow 81 and belongs to the technical field of fine chemical synthesis. The industrial production method comprises the following steps of: pulping, diazotizing and coupling such materials as 2,2',5,5'-tetrachlorobiphenyl amine hydrochloride, 2,4-dimethyl-N-acetoacetanilide and the like; stirring the materials for 1 hour to 4 hours after the reaction is finished; heating up the reaction liquid to 80 DEG C to 100 DEG C, preserving the heat for reaction for 30 minutes; cooling the reaction liquid to the room temperature, filtering the reaction liquid; and drying the reaction liquid at 70 DEG C to 100 DEG C to obtain the pigment yellow 81. According to the industrial production method disclosed by the invention, the reaction conditions are gentle, the device requirements are low, the reaction time is short; moreover, the obtained product pigment yellow 81has a high yield of more than 90%, good performances, acid resistance of lever four or higher, alkali resistance of level four or high, weather resistance of level six or higher, and heat resistance to 200 DEG C or high, and so the pigment yellow 81 disclosed by the invention can be applied to rubber with high performance requirements and high-level paint.