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Extraction process of small-molecular fucoidan and application of small-molecular fucoidan in cosmetics

A molecular fucoidan and extraction process technology, applied in cosmetics, cosmetic preparations, cosmetic preparations, etc., can solve the limitations of research and market development progress of fucoidan, low molecular weight of fucoidan, poor product fluidity, etc. problems, to achieve the effect of regulating inflammation and allergic reactions, promoting wound healing, and high antioxidant capacity

Inactive Publication Date: 2018-12-14
北京康塑生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, limited by the extraction technology, most of the fucoidan produced today are macromolecular heteropolysaccharides with complex components and unclear structure, which limits the progress of fucoidan research and market development
Patent CN106866834B discloses a method for preparing fucoidan products. The molecular weight of fucoidan prepared by this method is low, but its molecular weight ranges from 2000 to 10000 Da, and the molecular weight is still high. Moreover, the fluidity of the product is not good, which is not conducive to Subsequent application

Method used

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  • Extraction process of small-molecular fucoidan and application of small-molecular fucoidan in cosmetics
  • Extraction process of small-molecular fucoidan and application of small-molecular fucoidan in cosmetics

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Experimental program
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Effect test

Embodiment 1

[0034] The extraction process of small molecule fucoidan, the specific steps are as follows:

[0035] (1) the sea-tangle is washed, dried and pulverized by microwave irradiation to obtain the sea-tangle powder;

[0036] (2) adding the kelp powder to 10 times the weight of distilled water, stirring, and homogenizing under high pressure to obtain the wall-broken slurry of kelp;

[0037] (3) Add chitosan acetic acid solution to the kelp broken wall slurry, the volume ratio of the two is 6:1, stir for 10 minutes, add sodium perborate of 0.08 times the weight of kelp powder, continue stirring for 20 minutes, centrifuge, and collect the precipitate;

[0038] (4) Add the precipitate obtained in step (3) into 6 times the weight of distilled water while stirring, and ultrasonically vibrate for 30 minutes to obtain a dispersion;

[0039] (5) Add 0.02 times the weight of kelp powder lysozyme to the dispersion obtained in step (4), hydrolyze at 35°C for 3 hours, then add trifluoroacetic ...

Embodiment 2

[0052] The extraction process of small molecule fucoidan, the concrete steps are as follows:

[0053] (1) kelp washing, microwave irradiation drying, pulverization, to obtain kelp powder;

[0054] (2) kelp powder is added into the distilled water of 15 times of weight, stir, high pressure homogenization, obtains kelp broken wall slurry;

[0055] (3) add chitosan acetic acid solution to kelp broken wall slurry, the two volume ratio is 8:1, stir 15 minutes, add the sodium perborate of 0.1 times of kelp powder weight, continue to stir for 30 minutes, centrifuge, collect precipitation;

[0056] (4) adding the precipitate obtained in step (3) into distilled water of 8 times the weight while stirring, and ultrasonically oscillating for 30 minutes to obtain a dispersion;

[0057] (5) in the obtained dispersion liquid in step (4), add the lysozyme of 0.03 times of kelp powder weight, 45 ℃ of hydrolysis 5 hours, then add the trifluoroacetic acid of 0.02 times of kelp powder weight, be...

Embodiment 3

[0070] The extraction process of small molecule fucoidan, the concrete steps are as follows:

[0071] (1) kelp washing, microwave irradiation drying, pulverization, to obtain kelp powder;

[0072] (2) kelp powder is added in the distilled water of 10 times of weight, stir, high pressure homogenization, obtains kelp broken wall slurry;

[0073] (3) add chitosan acetic acid solution to the kelp broken wall slurry, the volume ratio of the two is 8:1, stir 10 minutes, add the sodium perborate of 0.1 times of kelp powder weight, continue to stir for 20 minutes, centrifuge, collect precipitation;

[0074] (4) adding the precipitate obtained in step (3) into distilled water of 8 times the weight while stirring, and ultrasonically oscillating for 30 minutes to obtain a dispersion;

[0075] (5) in the obtained dispersion liquid in step (4), add the lysozyme of 0.02 times of kelp powder weight, 45 ℃ of hydrolysis 3 hours, then add the trifluoroacetic acid of 0.02 times of kelp powder w...

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Abstract

The invention provides an extraction process of small-molecular fucoidan and an application of the small-molecular fucoidan in cosmetics. After kelp is made into kelp wall-broken slurry, a chitosan acetic acid solution is firstly used and is supplemented with sodium perborate to precipitate polysaccharides, and the precipitate is dispersed in distilled water and then is degraded by combining lysozyme with trifluoroacetic acid; and finally, the small-molecular fucoidan is separated by repeated freeze-thaw treatment. The obtained product has low molecular weight (200-300 Da), has high purity, has proper and good fluidity, and can be used for preparing the cosmetics.

Description

technical field [0001] The invention relates to the technical field of natural product extraction, in particular to the extraction process of small molecule fucoidan and its application in cosmetics. Background technique [0002] In 1913, Swedish scientist Kylin discovered fucoidan, a viscous component in brown algae, in the laboratory of Uppsala University. With the advancement of science and technology, people have realized that fucoidan is a kind of "intercellular polysaccharide" in brown algae plants. This polysaccharide mainly exists in the cell wall of brown algae plants, and its content is very small. [0003] Fucoidan is a natural complex polysaccharide, which contains a natural sulfate group at the end of the molecular chain, which makes it exhibit excellent and obvious physiological activities. Modern science has proved that fucoidan is not a compound with a single structure, but a family of compounds with different chemical components. The usual molecular weight...

Claims

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Application Information

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IPC IPC(8): C07H3/04C07H3/06C07H1/08A61K8/60A61Q19/00A61Q19/08
CPCA61K8/60A61Q19/00A61Q19/08C07H1/08C07H3/04C07H3/06
Inventor 赵磊王文加
Owner 北京康塑生物科技有限公司
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