The invention discloses processing production equipment and a processing method of a packaging substrate, and relates to the technical field of packaging substrate processing. The equipment comprises a base plate body, a machine body, a conveying mechanism, a lifting mechanism, a feeding mechanism, a drainage mechanism, a wiping mechanism, a pipeline mechanism and a drying mechanism, wherein the machine body is used for automatically carrying out feeding, acid pickling, clean water washing and drying operation on the base plate body; the base plate body comprises a ceramic substrate; and an inner layer thick copper foil and an outer layer thin copper foil are sequentially arranged on the two sides of the ceramic substrate. Through the arrangement of the machine body, the conveying mechanism, the lifting mechanism and the feeding mechanism, the base plate body to be subjected to acid pickling is automatically fed through conveying rollers, the base plate body is transferred among the acid pickling, wiping and drying procedures in cooperation with a feeding frame capable of moving left and right, and compared with a conventional manual feeding mode, the substrate body feeding efficiency is guaranteed, and meanwhile, the harm of the pickling solution to workers is avoided, and the usability of the device is guaranteed.