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Compound Dragon's Blood and Its Application in Preparation of Guaiac Medicine

A technology of dragon's blood and compound recipes, which can be used in drug combinations, pharmaceutical formulas, plant raw materials, etc., and can solve problems such as unseen, liver first-pass effect, irritation, etc.

Active Publication Date: 2016-10-05
张荣平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral preparations have a slow drug effect time, are irritating to the gastrointestinal tract, and have a first-pass effect on the liver. Now, the dry powder of dragon's blood is often used in combination with other drugs or the use of dragon's blood in clinical treatment of wounds or bedsores. ointment method
So far, in the prior art, there is no report on the application of a traditional Chinese medicine compound composed of dragon's blood and dried blood as the main prescription for the preparation of drugs for the treatment of wounds or tissue repair

Method used

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  • Compound Dragon's Blood and Its Application in Preparation of Guaiac Medicine
  • Compound Dragon's Blood and Its Application in Preparation of Guaiac Medicine
  • Compound Dragon's Blood and Its Application in Preparation of Guaiac Medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Determination of the formula of compound dragon's blood jerky / xuejie:

[0028] The compound dragon's blood jerky showed a certain therapeutic effect on promoting scab and scab healing in the mouse trauma test model, which is consistent with the pharmacological effect of dragon's blood jerky itself on removing putrefaction, promoting muscle growth and promoting wound healing. Coptis chinensis in this prescription has the effects of purging fire, detoxifying, clearing heat and moistening dryness, which can reduce the rate of wound infection and reduce local exudation at the initial stage of trauma, which is one of the therapeutic effects of the compound dragon's blood. Because the protective layer on the skin surface is destroyed in open wounds, bacteria can easily invade the wound and cause infection at the wound, so it has an astringent effect on the wound while keeping the wound free from infection to reduce the wound area. Borneol has cooling and pain-reducing effe...

Embodiment 2

[0077] Preparation of compound dragon's blood jerky (blood jerky) gel

[0078] In this experiment, after the Carbomer P940 is fully swollen in water, the drug is added to the solution and mixed thoroughly, and the pH value is adjusted with triethanolamine to make the gel reach a larger viscous consistency. The gel should have good gloss, spreadability, uniformity and centrifugality.

[0079] 1. Investigation of solvent types

[0080] According to the literature and clinical experience, the proportions of the three drugs in the prescription of the compound dragon's blood jerky were determined, and the compound was mainly composed of dragon's blood jerky. Dragon's blood has the physical and chemical properties of being insoluble in water, ether and dilute acidic solutions, and easily soluble in methanol, ethanol and alkaline solvents. Analyze and compare the dissolving conditions of different solvents for the compound drug, and select a solvent with good solubility and no irri...

Embodiment 3

[0105] Preparation of Compound Dragon's Blood Coating Agent

[0106] In this experiment, Bletilla striata glue was chosen as the material of the coating agent. It is a Chinese herbal medicine with less toxic and side effects on the human body, and Bletilla striata has the functions of astringent and hemostasis, detumescence and muscle regeneration, and wound repair. Clinically, it is widely used in the treatment of hemoptysis, hematemesis, traumatic bleeding, sore swelling, tuberculosis hemoptysis, ulcer bleeding and other diseases. Bletilla striata tubers are rich in bletilla striata gum, bletilla striata gum is a light yellow homogeneous jelly, soluble in water but insoluble in ethanol. It is a traditional Chinese medicinal material with various biological activities and has been widely used in clinical practice. In the production of therapeutic preparations, it has a wide range of medical application value. The main preparation method of bletilla striata gum is as follows:...

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Abstract

The invention provides a compound preparation which comprises dracaena cochinchinensis resin or daemonorops draco resin and other components and has the effects of trauma treatment, tissue repair, angiitis treatment and the like. The compound preparation is characterized in that the ratio of the dracaena cochinchinensis resin or the daemonorops draco resin to borneol is 9:1, and the ratio of the dracaena cochinchinensis resin or the daemonorops draco resin to berberine to borneol is 9:4:1, or the ratio of the dracaena cochinchinensis resin or the daemonorops draco resin to the berberine to the borneol is 1:1:0.15. The invention also provides a preparation method of the compound preparation and application of the dracaena cochinchinensis resin or daemonorops draco resin compound in the preparation of compound gels, liniment, cataplasm, adhesive bandages (such as patches) and other preparations. Compared with two positive medicines (Madecassol, jingwanhong soft plaster), the dracaena cochinchinensis resin or daemonorops draco resin compound preparation has the obvious effects of promoting wound healing and tissue repair. The acute toxicity test and the long-term toxicity test show that the preparation is safe to use.

Description

Technical field: [0001] The invention belongs to the technical field of medicines, and in particular relates to a drug compound preparation with dragon's blood or dried blood as the main component, a method for preparing the compound preparation and its application in the preparation of drugs for treating guaiac or tissue repair. Background technique: [0002] Blood jellyfish is warm and flat in nature, sweet and salty, non-toxic, enters the blood system, and returns to the three meridians of lung, spleen and kidney. Various internal and external subjects, such as: bruises, blood stasis, bleeding, carbuncle ulcers, sores that do not heal for a long time, etc., are important components of many ancient and empirical prescriptions. Restorative effect. The earliest medicinal dried blood used in my country "comes from the Western Regions", and its base plant is the Agave family plant Dracaena draco (Dracaena draco) produced in West Asia and North Africa. Since the Ming and Qing...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K9/70A61K36/896A61K36/889A61P17/02A61P17/00A61P17/10A61P9/14A61K31/4375A61K31/045
Inventor 张荣平余晓玲赵荣华赵昱巫秀美于浩飞石聪李雷袁小淋郝艳兵张琦郑园园张兰春
Owner 张荣平
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