Use of berberine in treating metabolism complex

Abstract

The invention provides a new application of berberine in the treatment of metabolic syndrome. Large-sample polycentric and randomized double-blind prospective experiments reveal the effect of berberine on metabolism of glucose and lipid and clarify the interrelation and common changes of the metabolism of glucose and lipid before and after berberine treatment. The berberine is used as a broad spectrum antibiotic and clinical drug with high efficiency and low toxicity for a long time and can be taken chronically without obvious side effect. Results of researches indicate that the berberine can help sufferers of type II diabetes mellitus combined with blood lipid abnormality regulate disorder of saccharometabolism and lipid metabolism, lower insulin resistance, avoid central obesity and elevation of blood pressure, thereby showing the positive effect of the berberine on the treatment of metabolic syndrome. The invention provides the new clinical application of berberine in the treatment of metabolic syndrome for human for the first time, which establishes the importance of the new clinical application of traditional Chinese medicine in the treatment of metabolic syndrome and provides a new basis as well, thereby helping to promote the traditional medicine of China.

Description

technical field [0001] The invention relates to a new application of berberine in treating metabolic syndrome. Background technique [0002] Berberine (Berberine), also known as berberine, is an isoquinoline alkaloid that exists in many plants of 4 families and 10 genera including Berberidaceae. Its molecular formula is [C20H18NO4]+ (see Figure 1), and its molecular weight is 371.8. There are many kinds of its chemical structure, including berberine hydrochloride, berberine sulfate, berberine citrate and berberine phosphate, among which the structure of berberine hydrochloride is most used clinically. [0003] Chemical structure of berberine: [0004] [0005] At present, as a broad-spectrum antibacterial drug with high efficiency and low toxicity, berberine is mainly used clinically to treat diarrhea caused by acute and chronic enteritis. The record of berberine treating diabetes was first seen in the "Famous Doctors" in the Wei and Jin Dynasties; as early as the begi...

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Problems solved by technology

[0009] 2) Although glucose and lipid metabolism are inseparable, most of the previous clinical and experimental studies only emphasized the positive impact of berberine on hyperglycemia, and only a recent literature studied the clinical lipid-lowering effect of berberine, but It only mentioned its effect on blood lipids, but did not link glucose and lipid metabolism with each other

[0011] 3) The research on berberine improving insulin resistance mostly stays at the level of animal experiments and in vitro studies, so far there is a lack of objective, accurate and effective evaluation in humans

Although there have been reports on the treatment of hyperglycemia, hyperlipidemia and insulin resistance by berberine respectively, for the treatment of metabolic syndrome in human body by berberine and the comprehensive observation of the changes of each component of the latter before and after treatment, so far So far, there have been no reports at home and abroad

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