Application of laggera pterodonta extract and composition in drug for resisting influenza A virus

A viral influenza and extract technology, applied in the field of medicine, can solve the problems such as viral influenza A virus that has not been seen in the extract of stinky Lingdan

Active Publication Date: 2014-04-23
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application of laggera pterodonta extract and composition in drug for resisting influenza A virus
  • Application of laggera pterodonta extract and composition in drug for resisting influenza A virus
  • Application of laggera pterodonta extract and composition in drug for resisting influenza A virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The extraction method of the stinky elixir extract: use the stinky elixir medicinal material, add one of ethanol, methanol, acetone, and ethyl acetate with 10 times the weight of the stinky elixir medicinal material, and extract it by cold soaking or percolation, reflux heating, and ultrasonic extraction The initial extract; the initial extract is processed as follows: add water with 2 times the weight of the initial extract, leave it for 2 hours, filter out the insoluble chlorophyll and resinous matter, concentrate the water under reduced pressure, add 2 times the amount of the concentrate Dehydrated ethanol, put it aside for 4 hours, filter out the alcohol-insoluble matter; repeat the alcohol solution to remove the water-insoluble matter, or directly recover the solvent until it is dry to obtain the extract of Stinky Panacea; or put the initial extract on a macroporous resin column or activated carbon column, and wash with water , remove water-soluble impurities, and t...

Embodiment 2

[0047] The extract of stink lingdan can be combined with rhubarb, honeysuckle and medicinal excipients to form a pharmaceutical composition. The parts by weight of each component are (kilograms): 80 stinkbud extract, 10 guanzhong, 10 honeysuckle, and necessary pharmaceutical excipients (the dosage can be prepared according to the prior art).

Embodiment 3

[0049] The parts by weight of each component of the medicinal composition of the stinky elixir extract are (kilograms): 70 stinky elixir extracts, 15 rhizoma guanzhong, 15% honeysuckle, and necessary pharmaceutical excipients (the dosage can be prepared according to the prior art) .

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Abstract

The invention discloses application of a laggera pterodonta extract and a composition in a drug for resisting influenza A virus. The laggera pterodonta extract can strongly suppress the respiratory tract influenza A virus. Active ingredients of the laggera pterodonta extract are obtained by extracting a wingedtooth laggera herb or re-leaching, depositing and chromatographing with ethanol, methanol or a fat soluble solvent. A series of experiments including cytopathic effect, blood clotting titer, RealTime RT-PCR (Reverse Transcription-Polymerase Chain Reaction) and so on are performed to the laggera pterodonta extract, in order to detect influenza A virus in-vivo neutralization and anti-proliferative effect of the laggera pterodonta extract samples. The laggera pterodonta extract and the active ingredients have the anti-influenza A virus activity, and have a prospect of being developed to a single-preparation or composite drug for resisting the influenza A virus.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of the stinkbud extract and its composition in anti-influenza A virus drugs. Background technique [0002] Laggera Pterodonta (DC.) Benth is a medicinal plant of the genus Hexagonal Chrysanthemum in the Compositae family. It is also known as Lion Grass, Smelly Leaf, and Hexagonal Chrysanthemum. It is distributed in Yunnan, Sichuan, Tibet and other places, and is mainly produced in Yunnan, my country. Province, rich sources of medicine. "Yunnan Chinese Herbal Medicine", "Kunming Folk Commonly Used Herbs" and "Southern Yunnan Materia Medica" have recorded a large amount of experience in Yunnan folks using Fenglingdan. This medicine has good antibacterial, anti-inflammatory, heat-clearing and detoxifying effects, and is widely used to treat colds , pharyngitis, bronchitis, malaria and other diseases. The compounds that have been identified from this genus are main...

Claims

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Application Information

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IPC IPC(8): A61K36/355A61K36/28A61P31/16
Inventor 张荣平王新华夏晓玲孙强明杨子峰于浩飞潘锡平
Owner KUNMING MEDICAL UNIVERSITY
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