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Process for extracting pterodontic acid from laggera pterodonta

A technology of fendanic acid and fendanic acid, which is applied in the field of plant extraction, can solve problems such as the extraction of fendanic acid.

Inactive Publication Date: 2011-05-04
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Stomadan acid is generally extracted from stinky pills. At present, most of the reports at home and abroad are mainly about the research on the active ingredients of stinky pills, but there is no relevant report on the extraction of smelttanic acid from stinky pills.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Dry the root of Stomadella to a water content lower than 13%, take 1 kg and crush it to 40 meshes to obtain the powder of Stomadella, extract it with 5% sodium hydroxide aqueous solution 6L at room temperature for 12 hours, filter to obtain the leaching solution, add 2 % acetic acid was acidified to pH 2 to obtain a precipitate; the precipitate was collected, and the precipitate was extracted 3 times with chloroform, and the chloroform layer was concentrated by rotary evaporation under reduced pressure to 1 / 20 of the extraction volume, and the macroporous resin was added to form a powder, and then The macroporous adsorption resin column is used for column chromatography, and the mixed eluent of ethyl acetate and methanol with a volume ratio of 3:1 is used for elution; the fraction enriched in malidan acid is collected, concentrated and then added to the macroporous The resin sample was mixed and put on the column, and the mixed solvent of petroleum ether-ethyl acetate wi...

Embodiment 2

[0018] Dry the root of Stomadella root until the water content is lower than 13%, take 1 kg and crush it to 60 mesh to obtain the powder of Storronia, extract it with 5L of saturated lime aqueous solution at room temperature for 24 hours, filter to obtain the leaching solution, add 5% hydrochloric acid to acidify When the pH is 1, a precipitate is obtained; collect the precipitate, extract the precipitate twice with ether, concentrate the ether layer by rotary evaporation under reduced pressure to 1 / 12 of the extraction volume, add a macroporous resin to form a powder, and then apply a macroporous Carry out column chromatography on an adsorption resin column, and elute with a mixed eluent of ethyl acetate and methanol with a volume ratio of 2:1; collect the fraction enriched in malidan acid, concentrate and then add macroporous resin to mix the sample Put it on the column, carry out gradient elution with a mixed solvent of petroleum ether-ethyl acetate with a volume ratio of 6:...

Embodiment 3

[0020] Dry the root of Stomadella root until the water content is lower than 13%, take 2 kg and crush it to 80 mesh to obtain the powder of Stomadella, extract it with 2% sodium bicarbonate aqueous solution 20L at room temperature for 18 hours, filter to obtain the leaching solution, add 0.5 % sulfuric acid was acidified to pH 2 to obtain a precipitate; the precipitate was collected, the precipitate was extracted once with methanol, the methanol layer was concentrated by rotary evaporation under reduced pressure to 1 / 15 of the extraction volume, and the macroporous resin was added to form a powder, and then The macroporous adsorption resin column is used for column chromatography, and the mixed eluent of ethyl acetate and methanol with a volume ratio of 3:1 is used for elution; the fraction enriched in malidan acid is collected, concentrated and then added to the macroporous The resin sample was mixed and put on the column, and the mixed solvent of petroleum ether-ethyl acetate...

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Abstract

The invention discloses a process for extracting pterodontic acid from laggera pterodonta, comprising drying and crushing laggera pterodonta root, leaching in an alkaline solution, standing and precipitating after the leaching solution is acidified to obtain a precipitate, collecting the precipitate, extracting for 1-3 times by using an organic solvent, concentrating the extract solution to obtain the concentrate; performing the macroporous adsorption resin column to the concentrate, using ethyl acetate-methanol to elute to obtain pterodontic acid enrichment flow, then concentrating, performing column chromatograph, using petroleum ether-ethyl acetate to perform gradient elution, recycling the reagent, concentrating and drying to obtain the product. The pterodontic acid obtained through the process has high purity of more than 98%.

Description

Technical field: [0001] The invention relates to a method for extracting sesquiterpenes from stinky dan, in particular to a process for extracting stinky acid from stinky dan, and belongs to the field of plant extraction. Background technique: [0002] Pterodontic acid is a naturally occurring sesquiterpene compound, molecular formula: C 15 h 22 o 2 . [0003] Yang Guangzhong et al. used the filter paper diffusion method to detect the antibacterial activity of feudanic acid and malodandiol, and the results showed that these two compounds were effective against Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, and Mycobacterium phlei. and Bacillus circulans showed significant antibacterial activity. [0004] Laggera pterodonta ((DC.) Beath) is a plant of the genus Sierongfeng (also known as Hexagonal Chrysanthemum) of Compositae. In Yunnan folks, Laggera pterodonta has been used as a good medicine for antibacterial, anti-inflammatory, heat-clearing and det...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C57/26C07C51/42
Inventor 刘东锋郭琴杨成东
Owner NANJING ZELANG MEDICAL TECH
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