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Curcumin emulsion, its preparation process and use

A technology of curcumin emulsion and curcumin, which is applied in the direction of pharmaceutical formula, emulsion delivery, medical preparations containing active ingredients, etc., can solve the problems that curcumin is not suitable for development into injections, etc., so as to improve the quality of life and inhibit metastasis , increase the effect of immune function

Inactive Publication Date: 2006-02-22
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Described in [Chinese herbal medicine, 2002,8 (25): 585-586] with DMSO solubilization, dissolves with Hanks solution, the valid period of the curcumin injection that makes is 0.2 year, and draws that it is not suitable to develop curcumin Injection conclusion

Method used

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  • Curcumin emulsion, its preparation process and use
  • Curcumin emulsion, its preparation process and use
  • Curcumin emulsion, its preparation process and use

Examples

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Effect test

preparation example 2

[0023] Preparation Example 2: Preparation of curcumin injection emulsion

[0024] Dissolve 500 mg of curcumin and 500 mg of oleic acid in ethanol and add it to 10 g of refined soybean oil, mix until clear, and remove the alcohol by rotary evaporation or nitrogen evaporation to obtain curcumin 50 mg / g and 50 mg / g oleic acid soybean oil solution.

[0025] Add 3.0 g of poloxamer and 2.25 g of glycerin to an appropriate amount of water for injection, and slowly add the oil solution containing curcumin and oleic acid dropwise into the above-mentioned water dispersion system under high-speed stirring conditions to make a coarse emulsion. Dilute to 100ml with water for injection. Under the condition of pressure 60Mpa, the crude emulsion obtained is further emulsified by a milk homogenizer, after the emulsification is finished, it is sterilized at 10°C for 30min, and then packed to obtain curcumin emulsion for injection 5mg / ml.

preparation example 3

[0026] Preparation Example 3: Preparation of Curcumin Oral Emulsion

[0027] Dissolve 5000 mg of curcumin and 3.0 g of egg yolk phospholipids in ethanol and add them to 40 g of corn oil, mix until clear, and remove the alcohol by rotary evaporation to obtain a corn oil solution containing 125 mg / g of curcumin and 75 mg / g of egg yolk phospholipids.

[0028] Under the condition of high-speed stirring, slowly drop the oil solution of phospholipid containing curcumin into the aqueous solution of an appropriate amount of 1% hydroxypropyl β-cyclodextrin to make a coarse emulsion, add pure water to 100ml, and divide it to obtain curcumin Emulsion 50mg / ml.

preparation example 4

[0029] Preparation Example 4: Preparation of curcumin injection emulsion

[0030] Dissolve 200 mg of curcumin and 2.0 g of hydrogenated lecithin in ethanol and add to 10 g of soybean oil, mix until clear, and remove the alcohol by rotary evaporation to obtain a soybean oil solution containing 20 mg / g of curcumin and 200 mg / g of hydrogenated lecithin .

[0031] Add 2.25 g of glycerin to an appropriate amount of water for injection, and slowly drop the oil solution containing curcumin and hydrogenated lecithin into the water phase under high-speed stirring conditions to make a coarse emulsion, and dilute to 100ml with water for injection. The obtained crude emulsion was further emulsified by a milk homogenizer under the condition of a pressure of 60Mpa. After the emulsification was completed, it was sterilized at 115° C. for 30 minutes, and then packed to obtain curcumin emulsion for injection 2 mg / ml.

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Abstract

The invention provides a curcumin oral emulsion and injection, wherein the emulsion comprises curcumin, oil, emulsifying agent and water, the injection also contains isotonic agent. The invention also discloses the process for preparing the emulsion and its use in preparing medicaments for treating or preventing tumor, resisting tumor transfer, enhancing curative effects of chemotherapy drugs, reducing side effects of chemotherapy and improving immunity functions for tumor patients.

Description

field of invention [0001] The present invention relates to curcumin emulsion and various preparation methods and applications thereof. Background technique [0002] Curcumin in a broad sense is usually called curcumin, which is derived from commonly used traditional Chinese medicines of the genus Curcuma long L., Curcuma wenyujin Y.H.Chen et C.Ling, Curcuma kwangsiensis S.G.Leeet C.F.Liang (Curcuma phaeocaulis Val.) The active ingredients isolated from the dry tuber root, including curcumin (curcumin), demethoxycurcumin (demethoxycurcumin) and bis-demethoxycurcumin (bis-demethoxycurcumin) [Liu Shuxing, Hu Xiaojun, Journal of Shaanxi University of Science and Technology: Natural Science Edition, 2003]. Unless otherwise specified below, curcumin refers to curcumin in a broad sense, and their structural formulas are as follows: [0003] [0004] I Curcumin R 1 =R 2 =CH 3 o [0005] II demethoxycurcumin Demethoxycurcumin R 1 = H R 2 =CH 3 o [0006] ...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K9/107A61P35/00
Inventor 王振华张雪梅马福禄苟海涛何杰
Owner SHANDONG LUYE PHARMA CO LTD
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