The present invention is a production method of vermiculite flame retardant medium density fiberboard, which includes selection of raw materials, preparation of surface layer, bottom layer and core layer, paving, pre-pressing, hot pressing, cooling, stacking, edge cutting, physical mechanics and combustion performance tests, etc. process steps. Advantages: due to the separate sizing of the surface layer, bottom layer and core layer materials, the amount of vermiculite added is based on the percentage of absolute dry fiber weight, the mechanical properties of the medium density fiberboard made by the present invention are better than the existing flame retardant and wood fiber Mechanical properties of medium density fiberboard made with mixed sizing. The results of the combustion performance test show that due to the addition of vermiculite accounting for 30-70% of the dry fiber weight in wood fibers, the heat release rate, total heat release, total smoke release, smoke yield and Mass loss rate, delayed ignition time. Tests have proved that with the increase of the amount of vermiculite added, the flame retardant performance of the product will increase. This product solves the problems of flammability and environmental protection, has low cost, and has both practical significance and promotion value.