Traditional Chinese medicine composition for treating primary nephrotic syndrome and preparation method thereof

A technology for primary nephropathy and a composition, applied in the field of traditional Chinese medicine, can solve the problems of high recurrence rate, many side effects, water and sodium retention hypertension and the like

Inactive Publication Date: 2013-07-24
王喜功
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  • Summary
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Problems solved by technology

If you take adrenal corticosteroids for a long time, it has been proven that there will be a lot of adverse reactions: fat metabolism disorder, edema, abnormal body fat distribution, etc.; protein decomposition, increased metabolism, negative balance of nitrogen, and muscle atrophy , muscle weakness, wounds are not easy to heal, etc.; sugar metabolism disorder leads to hyperglycemia and diabetes; Those who are prone to peptic ulcer and severe gastric perforation can lead to gastric perforation; pleasure and excitement in the mental and neurological aspects can lead to insomnia, and severe psychotic seizures can occur; due to the formation of inhibitory antibodies, infection and tuberculosis are more likely to occur and spread; a large number, Long-term medication can also cause cataract and aseptic necrosis of the femoral head; if children are in the growth period, their growth will be affected, especially their height; if the drug is stopped suddenly or in case of surgical infection, it can cause adrenal cortex function Insufficiency, causing eg nausea, vomiting, abdominal pain, shock
[0005] Standardized hormone therapy of western medicine has poor effect, many side effects, high recurrence rate and low complete remission rate
The reasons: 1. Long-term use of a large number of hormones reduces the body's immunity, and it is easy to cause respiratory tract, skin, and urinary tract infections; 2. Thrombosis and embolism, due to reasons such as decreased plasma albumin and high edema, the patient's effective blood circulation is insufficient. In addition, hyperlipidemia leads to increased blood viscosity, which causes the body's coagulation, anticoagulation and fibrinolytic system imbalance; 3. Due to the hyperfunction of platelets in primary nephrotic syndrome, the application of diuretics and glucocorticoids and other reasons, Accelerate hypercoagulation and promote the formation of a large number of microthrombosis in blood vessels

Method used

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  • Traditional Chinese medicine composition for treating primary nephrotic syndrome and preparation method thereof

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preparation example Construction

[0086] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition, specifically:

[0087] In the first step, mix Astragalus, Epimedium, Morinda officinalis, Shayuanzi, Yam, Acanthopanax, Gorgon, Polygonatum, Yizhi, Walnut, Dendrobium, Asparagus and Ligustrum in proportion, and add relative to the mixture Distilled water with a mass of 6 to 8 times was soaked for 0.5h to 1h, poured into a volatile oil extractor, extracted volatile oil by distillation for 6 to 8 hours to obtain volatile oil, filtered the remaining water extract to obtain the first filtrate, and added to the residue Distilled water with 4 to 6 times the mass is heated and boiled for 2h to 3h, the decoction is filtered to obtain the second filtrate, and the first filtrate and the second filtrate are combined to obtain a solution;

[0088] In the second step, the volatile oil obtained in the first step is diluted with ethanol at a volume ratio of 1:1 to ...

Embodiment 1

[0102] The preparation of embodiment 1 pill 1

[0103] Astragalus 87g, Epimedium 48g, Morinda officinalis 56g, Shayuanzi 61g, Yam 74g, Acanthopanax 70g, Euryale 26g, Polygonatum 78g, Yizhi 47g, Walnut kernel 55g, Dendrobium 44g, Asparagus 46g and Ligustrum lucidum Mix 47g, add 5.2kg of distilled water to soak for 1 hour, pour into a volatile oil extractor, extract the volatile oil by distillation for 8 hours to obtain volatile oil, filter the remaining water extract to obtain the first filtrate, add 2kg of distilled water to the residue, heat and boil 3h, filter the decoction to obtain the second filtrate, combine the first filtrate and the second filtrate to obtain a solution, dilute the previously obtained volatile oil with ethanol at a volume ratio of 1:1, and obtain the volatile oil ethanol dilution for subsequent use, weighing Put β-cyclodextrin in a container, the mass ratio of volatile oil to β-cyclodextrin is 1:4, add distilled water to dissolve in a ratio of 1:5, stir...

Embodiment 2

[0104] The preparation of embodiment 2 pill 2

[0105] Astragalus 85g, Epimedium 46g, Morinda officinalis 54g, Shayuanzi 59g, Yam 72g, Acanthopanax 68g, Gorgon fruit 24g, Polygonatum 76g, Yizhi 45g, Walnut kernel 53g, Dendrobium 42g, Asparagus 44g and Ligustrum lucidum Mix 45g, add 5kg of distilled water to soak for 1h, pour into the volatile oil extractor, extract the volatile oil by distillation for 8h to obtain volatile oil, filter the remaining water extract to obtain the first filtrate, add 2kg of distilled water to the residue, heat and boil for 3h , filter the decoction to obtain the second filtrate, combine the first filtrate and the second filtrate to obtain a solution, dilute the previously obtained volatile oil with ethanol at a volume ratio of 1:1, and obtain the volatile oil ethanol dilution for subsequent use, weigh β-cyclodextrin is placed in a container, the mass ratio of volatile oil to β-cyclodextrin is 1:4, add distilled water to dissolve at a ratio of 1:5, ...

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Abstract

The invention provides a traditional Chinese medicine composition for treating primary nephrotic syndrome. The traditional Chinese medicine composition comprises the following active pharmaceutical ingredients: membranous milkvetch root, liquorice root, epimedium herb, medicinal Indianmulberry root, flastem milkvetch seed, sappan wood, cowherb seed, zedoary tumeric, common anemarrhena rhizome, amur corktree bark, barbed skullcap herb, radix salviae miltiorrhizae, rice bean, common yam rhizome, manyprickle acanto-panax root, gordon euryale seed, rhizome, sharpleaf galangal fruit, fourstamen stephania root, walnut kernel, glabrous greenbrier rhizome, sinkiang arnebia root, sevenlobed yam rhizome, cochinchnese asparagus root, belvedere fruit, medcinal evodia fruit, lychee seed, dendrobium, glossy privet fruit and Chinese angelica. The traditional Chinese medicine composition provided by the invention is used for treating the primary nephrotic syndrome, can antagonize the side effects of hormones and other Western medicines, improve the blood flow of kidney, reduce urine proteins, retard kidney damages, improve the hypercoagulable state of a patient, consolidate efficacy, reduce the rebound phenomenon of the disease and realize few side effects, low recurrence rate and high complete relief rate, and has a certain efficacy for treating the primary nephrotic syndrome.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating primary nephrotic syndrome and a preparation method thereof. Background technique [0002] Kidney disease has become one of the major diseases endangering public health. Data show that in western developed countries, the population with varying degrees of kidney disease accounts for 6.5% to 10% of the total population. In China, due to non-standard treatment, drug abuse and unhealthy lifestyle, the incidence of kidney disease in our country has also increased year after year. Primary nephrotic syndrome is a very common clinical syndrome characterized by a large amount of urinary protein, high edema, hypoalbuminemia and hyperlipidemia. It can be caused by many kinds of kidney diseases, and it is now generally considered by the medical profession to be a cellular immune disease. At present, the routine ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/20A61K9/16A61P13/12
Inventor 刘冰甜
Owner 王喜功
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