The invention discloses serial medicine for treating chronic pelvic pain and a preparation method thereof. The serial medicine comprises a dysmenorrhea relieving prescription, an abdominal lump eliminating and pain easing prescription and an abdominal lump eliminating and clysis prescription; the dysmenorrhea relieving prescription is prepared from the following raw medicine materials: peach kernel, ground beetle, herba leonuri, rhizoma corydalis, cortex moutan, radix ampelopsis, spreading hedyotis herb, cortex eucommiae, radix morindae officinalis, radix astragali and honey-fried licorice root; the abdominal lump eliminating and pain easing prescription is prepared from the following raw medicine materials: radix codonopsis, radix astragali, radix linderae, radix salviae miltiorrhizae, turtle shell, cortex eucommiae, radix morindae officinalis, honeysuckle flower, fructus forsythiae, herba patriniae, fried coix seed, radix pulsatillae and honey-fried licorice root; the abdominal lumpeliminating and clysis prescription is prepared from the following raw medicine materials: kelp, seaweed, edible tulip, radix paeoniae rubra, sargentgloryvine stem, solanum dulcamara herb, herba patriniae, rhizoma coptidis and flos sophorae immaturus. The serial medicine provided by the invention combines oral administration and external use according to the physical characteristics of women during menstruation and after menstruation, and has the advantages of remarkable curative effect, less possibility of relapse, no obvious side effects, easiness in acceptation by patients, and no pain in the treatment process.