Drug with thrombus-curing function and preparation method thereof

Abstract

The invention discloses a drug with thrombus-curing function and a preparation method thereof. The drug for curing the thrombus comprises PEG-decorated earthworm plasmin and ganoderan with the purity larger than 93 percent and is prepared by the following steps: adding a buffer system, an isotonic agent, a stabilizing agent and a lyophilized protective agent to PEG-decorated earthworm plasmin protein and the ganoderan with the purity larger than 93 percent, mixing, freezing and drying to obtain power for injection. The invention adopts natural animal and plant medical materials as raw material sources, utilizes the comprehensive action of traditional Chinese medicine components to cure the thrombus, is proved to have no toxic action on human bodies by acute toxicity and long-term toxicological tests, has high medicine effect, can improve the hypercoagulative state of the blood and the blood fat, decreases the blood glucose, dissolves the thrombus, dredges the microcirculation and simultaneously improves the body immunity.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine capable of treating thrombosis and a preparation method thereof. Background technique [0002] Thrombosis is a common and frequently-occurring disease that seriously endangers human health. It is the culprit of cardiovascular and cerebrovascular diseases. Cardiovascular diseases in the world kill 12.5 million people every year. In my country, there are 3 million new such patients every year. Only 4%. The etiology is that the coagulation system and fibrinolytic system in the body are in an uncoordinated state, and the amount of active plasminase is not enough to decompose fibrin, the main component of thrombus, leading to thrombosis, acute myocardial infarction and other cardiovascular and cerebrovascular diseases. At present, the drugs for treating thrombosis are mostly blood vessel dilating and thrombolytic drugs. However, the former is expensive and the l...

AI Technical Summary

Problems solved by technology

[0004] However, earthworm fibrinolytic enzyme is easily decomposed and destroyed by enzymes and inhibitors in the body, and it is not easy to enter the lesion tissue and cause immunogenicity, and the half-life in the body is short

Of course, injections can also be used to make earthworm fibrinolytic enzymes enter the lesion tissue, but in clinical practice, it is restricted by many factors, such as allogeneic injections are prone to produce antigens, are eliminated in the kidneys, and have short half-lives in the body.