Application of ticagrelor in medicine for assisted therapy on anaphylatic purpura nephritis

A technology for purpura nephritis and ticagrelor, which is applied in allergic diseases, drug combination, drug delivery, etc., can solve the problems that patients are easy to form dependence on hormones and cannot prevent kidney damage, and achieve stable therapeutic effect and convenient treatment. Absorption, the effect of reducing the absorption rate

Inactive Publication Date: 2017-06-30
JIANGSU WANBANG BIOPHARMLS +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the curative effect of the above treatments is limited, and patients are pron

Method used

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  • Application of ticagrelor in medicine for assisted therapy on anaphylatic purpura nephritis
  • Application of ticagrelor in medicine for assisted therapy on anaphylatic purpura nephritis

Examples

Experimental program
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Effect test

Embodiment 1

[0013] Example 1 Adjuvant therapeutic effect of ticagrelor on allergic purpura nephritis

[0014] 1. Materials and methods

[0015] 1.1 Experimental objects and grouping

[0016] A total of 40 children with HSPN who were treated in outpatient and inpatient clinics were selected and randomly divided into a control group and a treatment group, 20 cases in each group.

[0017] Diagnostic criteria "Zhu Futang Practical Pediatrics" diagnostic criteria for allergic purpura. At the same time as the onset of the disease or within 1 month after the disease, urine microscopic examination showed positive red blood cells, deformed red blood cells in urine, positive proteinuria, very few accompanied by edema, high blood pressure, some only had asymptomatic microscopic hematuria, elevated serum IgA, IgM , IgG more than normal, complement C 3 、C 4 normal or elevated.

[0018] 1.2 Treatment methods

[0019] The control group received conventional treatment with immunosuppressant cycloph...

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Abstract

The invention provides new medical application of ticagrelor, namely a medicine for assisted therapy on anaphylatic purpura nephritis. The new medical application has the advantages that the anaphylatic purpura nephritis can be used for inhibiting the sticking and agglomeration of blood platelet, the formation of blood coagulation and microthrombus in glomerulus is reduced, the positive function on treating the anaphylatic purpura nephritis is realized, the survival state and living quality of a patient with the anaphylatic purpura nephritis can be greatly improved, the reliance of the patient on hormone is avoided, and the toxic or side effect of the hormone is reduced.

Description

technical field [0001] The present invention relates to a new application of ticagrelor, in particular to the application of ticagrelor in adjuvant treatment of allergic purpura nephritis. Background technique [0002] Henoch-Schonlein purpura (HSP) is a self-limiting disease, the basic lesion is diffuse vasculitis accompanied by immunoglobulin (Ig) A immune complex deposition in the skin, joints, kidneys, gastrointestinal tract, etc. multisystem disease. Henoch-Schonlein purpura nephritis (HSPN) refers to the kidney damage caused by the deposition of IgA immune complexes in HSP in kidney tissue. According to domestic reports, the incidence rate of HSPN in HSP is 30%-50%, and in foreign reports, it is 40%-50%, accounting for 8% of children's urinary system diseases, second only to acute nephritis. In addition to skin purpura, hemorrhagic gastroenteritis, arthritis and kidney damage, the clinical manifestations are mainly single hematuria or / and proteinuria, which may be ac...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K9/22A61P13/12A61P37/08A61P7/04
CPCA61K9/0002A61K9/20A61K31/519
Inventor 文良柱梅丽栗凤娟牛瑞娟
Owner JIANGSU WANBANG BIOPHARMLS
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