Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Gastrodia-tuer powder injection

A technology of gastrodin and powder injection, applied in the field of injection medicine, can solve the problems of easy freezing of water injection, unstable drug effect, short storage period, etc., and achieve the effects of reducing the number of convulsions, shortening the dizziness time, and long storage period

Inactive Publication Date: 2003-03-26
KPC PHARM INC
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the continuous expansion of production, quality problems also appear from time to time, such as easy to produce precipitation, unstable drug effect, short storage period, water injections are easy to freeze or condense in winter, which is inconvenient to use, and the water injections at low temperature are injected intramuscularly. Pain, patients are unwilling to use it, and it is easy to break during transportation, and the packaging needs to be strengthened, all of which set up obstacles for the expansion of use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] [Example 1] Gastrodin is used as a raw material in a workshop above 100 grades, mannitol of 2 times the weight of the raw material is added, water of 10 times the weight of the raw material is added, dissolved at 60 ° C, the pH is adjusted to 6.0, and the solution is sterile Filtrate, aseptically spray-dry until the water content is 3%, airtightly obtain the required powder injection raw materials, sub-package into 5ml vials of 200mg, crimp the cap, and pack to obtain the finished product. Measured: gastrodin 32%, mannitol 65% , containing 3% water.

Embodiment 2

[0020] [Example 2] In the rear section (refinement section) of the gastrodin production workshop, the refinement section is placed in a workshop (space) above 100 levels to operate, and before the gastrodin is separated out, add a ratio of 1: 1 auxiliary material to adjust the pH value 6.0, after sterile filtration, the gastrodin is separated out by solvent method, suction filtration (or pressure filtration), and drying below 100 ℃ to 1% water content, that is, the raw material for powder injection (spray drying method can also be used), which is further packaged into In 600mg / 10ml vials, crimp the cap, and pack to obtain the finished product. Gastrodin 49.5%, auxiliary materials 49.5%, and water content 1%.

Embodiment 3

[0021] [Example three] In a workshop above 100 grades, 400g of gastrodin, 141.4g of glucose, and 30g of sodium chloride are dissolved in water for injection to make 4000ml, heated to dissolve, filtered, subpackaged into 4.0ml each, and freeze-dried , cover the rubber stopper, and roll the cap to obtain the freeze-dried powder injection of each 400mg (active ingredient), measured 70% of gastrodin, 28% of auxiliary materials, and 2% of water.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a gastrodine powder injection preparation. It is made up by using gastrodine as main component, its content is 30-99.9%, and water soluble medicinal auxiliary or water or their mixture. Said powder injection is good in stability, less in toxic side effect and extensive application range, and possesses the function of sedation, analgesia, hypnotic action, resisting vertigo, resisting convulsion, resisting epilepsy, improving cardio-carebral vascular function and resisting senility, etc.

Description

[0001] Technical field: the present invention relates to the technical field of injection medicine. Background technique: [0002] Gastrodia elata B1. is a famous and precious traditional Chinese medicine mainly produced in Yunnan. Research in recent years has found that Gastrodia elata also has the functions of increasing intelligence, strengthening the brain, and delaying aging, and has a certain effect on senile dementia. Modern studies have confirmed that gastrodin is one of its active ingredients. In the 1970s and 1980s, Chinese scientists began to research and develop gastrodin injection. Now gastrodin injection has been clinically used and welcomed by the majority of patients. However, with the continuous expansion of production, quality problems also appear from time to time, such as easy to produce precipitation, unstable drug effect, short storage period, water injections are easy to freeze or condense in winter, which is inconvenient to use, and the water injections...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/14
Inventor 普俊学李南高
Owner KPC PHARM INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com