Gastrodia-tuer powder injection

A technology of gastrodin and powder injection, applied in the field of injection medicine, can solve the problems of easy freezing of water injection, unstable drug effect, short storage period, etc., and achieve the effects of reducing the number of convulsions, shortening the dizziness time, and long storage period

Inactive Publication Date: 2003-03-26
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the continuous expansion of production, quality problems also appear from time to time, such as easy to produce precipitation, unstable drug effect, short storage period, water injections are easy to freeze or condense in winter, which is inconvenient t

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] [Example 1] Gastrodin is used as a raw material in a workshop above 100 grades, mannitol of 2 times the weight of the raw material is added, water of 10 times the weight of the raw material is added, dissolved at 60 ° C, the pH is adjusted to 6.0, and the solution is sterile Filtrate, aseptically spray-dry until the water content is 3%, airtightly obtain the required powder injection raw materials, sub-package into 5ml vials of 200mg, crimp the cap, and pack to obtain the finished product. Measured: gastrodin 32%, mannitol 65% , containing 3% water.

Embodiment 2

[0020] [Example 2] In the rear section (refinement section) of the gastrodin production workshop, the refinement section is placed in a workshop (space) above 100 levels to operate, and before the gastrodin is separated out, add a ratio of 1: 1 auxiliary material to adjust the pH value 6.0, after sterile filtration, the gastrodin is separated out by solvent method, suction filtration (or pressure filtration), and drying below 100 ℃ to 1% water content, that is, the raw material for powder injection (spray drying method can also be used), which is further packaged into In 600mg / 10ml vials, crimp the cap, and pack to obtain the finished product. Gastrodin 49.5%, auxiliary materials 49.5%, and water content 1%.

Embodiment 3

[0021] [Example three] In a workshop above 100 grades, 400g of gastrodin, 141.4g of glucose, and 30g of sodium chloride are dissolved in water for injection to make 4000ml, heated to dissolve, filtered, subpackaged into 4.0ml each, and freeze-dried , cover the rubber stopper, and roll the cap to obtain the freeze-dried powder injection of each 400mg (active ingredient), measured 70% of gastrodin, 28% of auxiliary materials, and 2% of water.

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PUM

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Abstract

The present invention relates to a gastrodine powder injection preparation. It is made up by using gastrodine as main component, its content is 30-99.9%, and water soluble medicinal auxiliary or water or their mixture. Said powder injection is good in stability, less in toxic side effect and extensive application range, and possesses the function of sedation, analgesia, hypnotic action, resisting vertigo, resisting convulsion, resisting epilepsy, improving cardio-carebral vascular function and resisting senility, etc.

Description

[0001] Technical field: the present invention relates to the technical field of injection medicine. Background technique: [0002] Gastrodia elata B1. is a famous and precious traditional Chinese medicine mainly produced in Yunnan. Research in recent years has found that Gastrodia elata also has the functions of increasing intelligence, strengthening the brain, and delaying aging, and has a certain effect on senile dementia. Modern studies have confirmed that gastrodin is one of its active ingredients. In the 1970s and 1980s, Chinese scientists began to research and develop gastrodin injection. Now gastrodin injection has been clinically used and welcomed by the majority of patients. However, with the continuous expansion of production, quality problems also appear from time to time, such as easy to produce precipitation, unstable drug effect, short storage period, water injections are easy to freeze or condense in winter, which is inconvenient to use, and the water injections...

Claims

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Application Information

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IPC IPC(8): A61K9/14
Inventor 普俊学李南高
Owner KPC PHARM INC
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