The invention discloses
lactobacillus mucosa with porcine
virus resisting activity and application of the
lactobacillus mucosa, and relates to the technical field of
microorganism application and
virus prevention and control. It is found for the first time that the
lactobacillus mucosa has broad-spectrum antiviral activity, not only has a remarkable inhibition effect on
porcine reproductive and respiratory syndrome virus type 2 (PRRSV2) strains, but also can further
resist porcine epidemic diarrhea virus (PEDV) and
porcine rotavirus (PoRV); according to the present invention, the
Lactobacillus mucosa is adopted to culture the supernatant, such that the supernatant does not have
toxicity on Marc-145 cells; according to the PRRSV2 strain treated by using the supernatant, the expression level of
virus RNA and
protein and the filial generation virus
titer are remarkably reduced, so that the infection ability is weakened; the culture supernatant directly acts with virus particles to block infection and replication of the virus particles; the product disclosed by the invention is derived from natural probiotics, is high in safety, environment-friendly and not easy to
resist drugs, can be used for preparing a broad-spectrum anti-porcine virus biological preparation, provides a new strategy for preventing and controlling porcine
virus diseases, and has a good industrial application prospect.