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A kind of anti-porcine virus disease mixed freeze-dried powder and preparation method thereof

A technology for viral diseases and porcine viral diseases, which is applied in the field of preparation of mixed freeze-dried powder, can solve problems such as inconvenient operation, difficult storage of medicines, and poor effect, and achieve strong pertinence, improve the effect of preventing and controlling porcine viral diseases, The effect of broad application prospects

Inactive Publication Date: 2016-08-17
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a mixed freeze-dried powder against porcine viral diseases, which solves the problems of inconvenient operation, difficult preservation of medicaments and poor effect in the prevention and treatment of porcine viral diseases in the prior art

Method used

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  • A kind of anti-porcine virus disease mixed freeze-dried powder and preparation method thereof
  • A kind of anti-porcine virus disease mixed freeze-dried powder and preparation method thereof
  • A kind of anti-porcine virus disease mixed freeze-dried powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The mixed freeze-dried powder of anti-swine viral disease of the present embodiment is the mixed freeze-dried powder of anti-swine fever, comprising the following components in parts by weight: 90 parts of anti-swine fever yolk antibody, 2 parts of anti-swine fever transfer factor, vitamin 1 part of C, 1 part of vitamin E, 2 parts of α-interferon, 1 part of active lactobacillus, 0.02 part of thimerosal, 0.2 part of formaldehyde, 0.05 part of selenium, 2 parts of polyvinylpyrrolidone, and 0.5 part of glycine.

[0039] The preparation method of the mixed freeze-dried powder of anti-swine fever of the present embodiment comprises the following steps:

[0040] 1) Propagate the standard strain of classical swine fever virus, inactivate it to prepare a vaccine, immunize healthy laying hens every 7 days, and immunize three times in total. For the first time, immunize healthy chickens with 1.5ml of inactivated vaccine , the second and third immunizations were doubled, and the a...

Embodiment 2

[0046] The anti-porcine viral disease mixed lyophilized powder of the present embodiment is an anti-porcine pseudorabies mixed lyophilized powder, comprising the following components in parts by weight: 93 parts of anti-porcine pseudorabies egg yolk antibody, anti-porcine pseudorabies transfer factor 1.5 0.5 parts of vitamin C, 0.5 parts of vitamin E, 1.5 parts of α-interferon, 1 part of active lactobacilli, 0.01 parts of thimerosal, 0.3 parts of formaldehyde, 0.1 parts of selenium, 1.5 parts of polyvinylpyrrolidone, and 1 part of glycine.

[0047] The preparation method of the mixed freeze-dried powder of anti-porcine pseudorabies of the present embodiment comprises the following steps:

[0048] 1) Propagate the standard strain of porcine pseudorabies virus, inactivate it to prepare a vaccine, immunize healthy laying hens every 7 days, and immunize three times in total. ml, double the dose for the second and third immunizations, and start to detect the antibody titer after th...

experiment example 1

[0054] In this experimental example, performance testing was performed on the mixed freeze-dried powder obtained in Examples 1-2, and the results are shown in Tables 1 and 2.

[0055] Experimental method for potency detection at room temperature: store the mixed freeze-dried powder preparations obtained in Examples 1-2 in a 37°C incubator for 24 months, at 1 week, 2 weeks, January, February, April, and 8 months respectively After 1 month, 12 months, 16 months, 20 months, and 24 months, the change of yolk antibody titer in the samples taken at each time point was measured by agar diffusion (AGP) method.

[0056] Table 1 embodiment 1~2 gained mixed freeze-dried powder room temperature potency detection experimental result

[0057] group

1 week

Two weeks

January

February

April

August

December

16 months

20 months

24 months

Example 1

1：32

1：32

1：32

1：32

1：32

1：32

1；16

1：16

1：16

1：16

Example...

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Abstract

The invention discloses a mixed freeze-dried powder for resisting swine viral diseases and a preparation method thereof. The mixed freeze-dried powder comprises the following components in parts by weight: 90-95 parts of anti-swine virus disease yolk antibody, anti-swine virus disease 1-2 parts of transfer factor, 1-2 parts of α-interferon, 1-2 parts of antioxidant, 0.01-0.02 part of preservative, 0.2-0.3 part of inactivator, 0.05-0.1 part of selenium, 1-2 parts of polyvinylpyrrolidone 0.5-1 part of glycine, 0.5-1 part of active lactobacillus. The anti-porcine viral disease mixed freeze-dried powder of the present invention is compounded with anti-porcine viral disease egg yolk antibody, anti-porcine viral disease transfer factor and immune enhancer, supplemented with various auxiliary materials, and each component cooperates and coordinates It can significantly improve the effect of preventing and treating porcine viral diseases, and has the advantages of strong pertinence, long storage time at room temperature, high antibody titer, and good biological activity.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to a mixed freeze-dried powder for resisting porcine viral diseases, and also relates to a preparation method of the mixed freeze-dried powder for resisting swine viral diseases. Background technique [0002] Porcine viral disease is a general term for different degrees of acute and highly contagious diseases caused by different viruses, including swine fever, porcine ring disease, porcine pseudorabies, porcine parvovirus disease and other diseases. Porcine viral disease is the most common disease in the pig industry. Because of its sudden onset, short course of disease, and high mortality, it is still one of the main hazards in the pig industry. [0003] There are many ways to prevent and treat porcine viral diseases at present, mainly using western medicine, vaccination, Chinese herbal medicine, etc. to prevent and treat. Among them, the widespread use of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/42A61K9/19A61K47/32A61P31/12A61K39/39A61K38/21
Inventor 郭俊清徐进陈建晖
Owner ZHENGZHOU HOUYI PHARMA
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