Pomegranate peel polyphenol antibiosis and antiphlogosis effervescent tablet as well as preparation method and application thereof

An antibacterial and anti-inflammatory technology, pomegranate peel technology, applied in the direction of antibacterial drugs, antifungal agents, pharmaceutical formulations, etc., can solve the problems of complex extraction process, no report on effervescent tablets, complex ingredients, etc., to achieve convenient use, overcome The effect of poor stability and long storage period

Active Publication Date: 2010-05-05
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent 200610164376.1: an effervescent tablet for treating vaginitis in women and its preparation method and use, Chinese patent 200910113244.X: a Fujie effervescent tablet and its preparation method and use, both of which are traditional Chinese medicine compound preparations. The process is complicated, and the ingredients that exert the medicinal effect are also complicated
According to domestic and foreign literature reports, there are many effervescent tablets mainly made of chemical drugs, but there are no reports on effervescent tablets made from traditional Uighur medicine commonly used medicinal materials as the main raw material.

Method used

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  • Pomegranate peel polyphenol antibiosis and antiphlogosis effervescent tablet as well as preparation method and application thereof
  • Pomegranate peel polyphenol antibiosis and antiphlogosis effervescent tablet as well as preparation method and application thereof
  • Pomegranate peel polyphenol antibiosis and antiphlogosis effervescent tablet as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: (based on making 1000 pieces)

[0046] a. First, weigh the pomegranate peel of the raw material and crush it into a coarse powder, add 5 times the concentration of 50% ethanol and extract it by warm soaking at 30°C once for 3 hours, filter, and recover the ethanol from the filtrate under reduced pressure. -8 macroporous resin chromatographic column, adsorb for 6 hours, first elute with distilled water until the effluent is almost colorless, then elute with 40% ethanol, collect until the eluate is colorless, concentrate, and remove ethanol at 60°C, Concentrate and dry under reduced pressure to obtain extract powder, pulverize, pass through a 60-mesh sieve to obtain 60 g of pomegranate peel polyphenols, and set aside;

[0047] b. Take 50 g of auxiliary materials sodium bicarbonate and 70 g of citric acid, grind them through a 100-mesh sieve respectively, and set aside;

[0048] c. Mix the powder of step a, the mixture of step b and 160g of lactose evenly, u...

Embodiment 2

[0052] Embodiment 2 (based on making 1000 pieces)

[0053] a. First weigh the raw material pomegranate peel and crush it into a coarse powder, add 10 times the concentration of 60% ethanol and extract it by soaking at 50°C for 4 times, 1 hour each time, filter, and recover the ethanol from the filtrate under reduced pressure. D101 macroporous resin chromatographic column, adsorb for 12 hours, first elute with distilled water until the effluent is nearly colorless, then elute with 60% ethanol, collect until the eluate is colorless, concentrate, remove ethanol at 50°C, and then reduce Concentrate and dry to obtain extract powder, pulverize, and pass through an 80-mesh sieve to obtain 120 g of pomegranate peel polyphenols, which are set aside;

[0054] b. Take 80 g of auxiliary materials sodium bicarbonate and 110 g of tartaric acid, pulverize them respectively through a 100-mesh sieve, and set aside;

[0055] c. Mix the powder of step a, the mixture of step b and 220 g of lacto...

Embodiment 3

[0059] Embodiment 3 (based on making 1000 pieces)

[0060] a. First weigh the raw material pomegranate peel and pulverize it into a coarse powder, add 15 times the concentration of 60% ethanol and extract by warm soaking at 50°C for 2 times, each time for 2 hours, filter, the filtrate is decompressed to recover ethanol, and the liquid is passed through HPD300 macroporous resin chromatographic column, adsorb for 8 hours, first elute with distilled water until the effluent is nearly colorless, then elute with 60% ethanol, collect until the eluate is colorless, concentrate, remove ethanol at a temperature of 55°C, reduce Concentrate and dry to obtain extract powder, pulverize, and pass through an 80-mesh sieve to obtain 315 g of pomegranate peel polyphenols, which are set aside;

[0061] b. Take 150g of auxiliary materials sodium bicarbonate and 200g of citric acid, grind them through a 100-mesh sieve respectively, and set aside;

[0062] c. Mix the powder of step a, the mixture...

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Abstract

The invention relates to a pomegranate peel polyphenol antibiosis and antiphlogosis effervescent tablet as well as a preparation method and application thereof. The effervescent tablet is mainly prepared by raw material of pomegranate peel polyphenol, and auxiliary materials of sodium hydrogen carbonate, citric acid or tartaric acid, lactose, polyvinylpyrrolidone, magnesium stearate and superfine silica powder, has the functions of clearing heat, eliminating dampness, killing bugs and stopping itching, has strong suppression effect to women vagina pathogenic bacteria, features high safety, good stability, no obvious toxic or side effect, or drug tolerance, and provides convenience in using, carrying and storing for patients, is used for curing such diseases as vaginitis, vulvitis and the like caused by various trichomonad, epiphyte and bacteria, and can be used as preventability medicine for long-term use.

Description

technical field [0001] The invention relates to an effervescent tablet with antibacterial and anti-inflammatory activity for external use prepared from pomegranate peel polyphenols and its application. Background technique [0002] Gynecological diseases refer to diseases caused by infections of the female reproductive system. Due to the particularity of female reproductive organs, gynecological diseases have become common and frequently-occurring diseases in adult women, with various clinical manifestations, complicated etiology and often accompanied by a variety of serious complications, which have brought great impact on women's life and work. influences. In addition, with today's environmental pollution, competitive pressure, accelerated pace of work, and changes in lifestyle, gynecological diseases will continue to increase, and will show a trend of younger and younger age. According to the survey of Chinese women by the World Health Organization, 41% of female patien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/46A61K47/32A61P15/02A61P31/04A61P31/10A61P33/02A61K131/00
Inventor 阿吉艾克拜尔·艾萨罗玉琴李洋蒋岚热依木古丽刘力
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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