Epalrestat tablet, and its prepn. method

A technology of epalrestat tablets and epalrestat, which is applied in the field of epalrestat tablets and its preparation, can solve the problems of poor dissolution rate and poor fluidity, and achieve good dissolution rate, simple preparation process, The effect of high hardness

Inactive Publication Date: 2005-11-09
YANGTZE RIVER PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The raw material of epalrestat is hydrophobic, the dissolution rate is not good and the fluidity is not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1: 1000 Epalrestat tablets were prepared with the following raw materials: 50g of epalrestat, 29g of lactose, 37g of microcrystalline cellulose, 4g of low-substituted hydroxypropyl cellulose, 3.7g of sodium carboxymethyl starch, and 1.2g of magnesium stearate His piece.

[0009] Preparation:

[0010] (1) Crushing the raw and auxiliary materials through a 100-mesh sieve, weighing epalrestat, lactose, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose according to the formula, and mixing them uniformly in a wet mixing granulator.

[0011] (2) Use 3% hydroxypropyl methylcellulose as a soft material, make wet granules with an 18-mesh sieve, dry in a hot air circulation oven at 55°C to 65°C, and control the moisture content to be less than 3%.

[0012] (3) After 18-mesh sieve granulation, it is finally mixed with the formula amount of sodium starch glycolate and magnesium stearate, and the content of the granules is measured, tabletted, coated, ...

Embodiment 2

[0013] Example 2: Prepare 1000 epalrestat tablets with the following raw materials: 50g of epalrestat, 40g of lactose, 27g of microcrystalline cellulose, 3g of low-substituted hydroxypropyl cellulose, 30g of sodium carboxymethyl starch, and 2g of magnesium stearate . The preparation method is the same as above.

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Abstract

A tablet for epalrestat for suppressing the transmission speed decreasement of sciatic nerve and coccygeal nerve and the increasement of sorbitol in red cell and sciatic nerve is prepared from lactose, microcrystalline cellulose, low-substituent hydroxypropyl cellulose, carboxymethyl starch sodium magnesium stearate and epalrestat through sequential mixing, granulating, drying, coating and tabletting.

Description

technical field [0001] The invention relates to epalrestat tablets and a preparation method thereof. Background technique [0002] The raw material of epalrestat has hydrophobicity, poor dissolution rate and poor fluidity. Contents of the invention [0003] In order to solve the above problems, the present invention provides an epalrestat tablet and a preparation method thereof. [0004] An epalrestat tablet of the present invention, the raw material weight composition is: 15%-65% of epalrestat, 10%-80% of lactose, 10%-80% of microcrystalline cellulose, low-substituted hydroxypropyl cellulose 1% to 10%, sodium starch glycolate 1% to 10%, magnesium stearate 0.1% to 3%. [0005] The preparation method of epalrestat tablets is to weigh and sieve epalrestat, lactose, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose according to the weight composition of raw materials and mix them uniformly in a wet mixing granulator, and use hydroxyl Propyl methyl cel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/425
Inventor 孙海胜陆小平陈娟余慧剑孙路进
Owner YANGTZE RIVER PHARM GRP CO LTD
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