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Solid instant preparation extracted from ginkgo leaf and its preparing process

A technology of Ginkgo biloba leaves and extracts, which is applied in the field of solid instant preparations of Ginkgo biloba extracts, can solve the problems of low dissolution rate and bioavailability of granules, aging of soft capsules and dropping pills, poor stability of oral liquids, etc. The effect of rapid dissolution, rapid absorption and short disintegration time

Inactive Publication Date: 2005-06-08
BEIJING BOERDA BIO TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the ginkgo biloba preparations that have been on the market and are being developed include tablets, soft capsules, oral liquids, granules, capsules, drop pills and injections. problems; tablets, capsules, and granules have problems such as low dissolution rate and bioavailability; oral liquids have poor stability, and storage and transportation are inconvenient; soft capsules and dripping pills have aging problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1-gingko biloba dispersible tablet

[0033] Ginkgo Biloba Extract 40g

[0034] Microcrystalline Cellulose 85g

[0035] Sodium carboxymethyl starch 9g

[0036] 2% hypromellose appropriate amount

[0037] Aspartame 0.2g

[0038] Lemon essence 0.2g

[0039] Magnesium Stearate 1.0g

[0040] —————————————

[0041] A total of 1000 pieces were made

[0042] Preparation method: 1. Take hypromellose and add water to make a 2% solution.

[0043] 2. Take ginkgo biloba extract, microcrystalline cellulose and sodium carboxymethyl starch which is half of the prescription amount, pass through a 100 mesh sieve and mix evenly with 2% hypromellose to make soft material. Granulate with a 20-mesh sieve, dry at 50°C for 20 minutes, and granulate with a 20-mesh sieve. Add aspartame, lemon essence, magnesium stearate, and the remaining amount of sodium carboxymethyl starch, mix well, and press into tablets.

[0044] The tablets prepared above were tested for dissolution u...

Embodiment 2

[0047] Embodiment 2-Ginkgo biloba dispersible tablet

[0048] Ginkgo Biloba Extract 40g

[0049] Microcrystalline Cellulose 70g

[0050] Crospovidone 15g

[0051] 5% povidone appropriate amount

[0052] Aspartame 0.2g

[0053] Lemon essence 0.2g

[0054] Magnesium Stearate 1.0g

[0055] ———————————————

[0056] A total of 1000 pieces were made

[0057] Preparation method: 1. Take povidone and add water to make a 5% solution.

[0058] 2. Take ginkgo biloba extract and microcrystalline cellulose and pass through a 100-mesh sieve, mix them evenly, and use 5% povidone to make a soft material. Granulate with 18-mesh sieve, dry at 50°C, and granulate with 18-mesh sieve. Add aspartame, lemon essence, magnesium stearate, and crospovidone, mix well, and press into tablets.

[0059] The tablets prepared above were tested for dissolution uniformity and dissolution rate according to the aforementioned method, and the results are shown in Table 2.

[0060] Uniformity of...

Embodiment 3

[0061] Embodiment 3-gingko biloba dispersible tablet

[0062] Ginkgo biloba extract 80g

[0063] Microcrystalline Cellulose 100g

[0064] Croscarmellose Sodium 40g

[0065] 5% povidone appropriate amount

[0066] Aspartame 0.5g

[0067] Lemon essence 0.5g

[0068] Magnesium Stearate 2.0g

[0069] ———————————

[0070] A total of 1000 pieces were made

[0071] Preparation method: 1. Take povidone and add water to make a 5% solution.

[0072] 2. Take ginkgo biloba extract and microcrystalline cellulose and pass through a 100-mesh sieve, mix them evenly, and use 5% povidone to make a soft material. Granulate with a 20-mesh sieve, dry at 50°C, and granulate with a 20-mesh sieve. Add aspartame, lemon essence, magnesium stearate, and croscarmellose sodium, mix well, and press into tablets.

[0073] The tablets prepared above were tested for dissolution uniformity and dissolution rate according to the aforementioned method, and the results are shown in Table 3.

[0074] ...

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PUM

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Abstract

An instant solid preparation of gingko leaf extract is disclosed, which includes the dispersing tablet prepared by freeze drying, spray drying, or direct tabletting press and coating, tabletting press methods, and the oral disintegrating tablet prepared from gingko leaf extract, disintegrant, filler, adhesive, lubricant and flavouring.

Description

technical field [0001] The invention relates to a solid instant preparation of ginkgo leaf extract, in particular to a ginkgo leaf extract dispersible tablet and an orally disintegrating tablet, and simultaneously, the invention also relates to a preparation method of the two preparations. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba plant, also known as ginkgo leaf. According to "Diet Therapy Materia Medica", Ginkgo biloba can be used for heart palpitations, lung deficiency cough and asthma and other diseases. The active ingredients in Ginkgo biloba mainly contain flavonoids, which can protect capillary permeability, dilate coronary arteries, restore arterial blood vessel elasticity, nourish brain cells and other organs, and also make arteries, peripheral blood vessels, and capillaries The unique effect of maintaining blood quality and cholesterol at normal levels. Ginkgo biloba preparations are used to treat angina pectoris of coronary heart d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P1/16A61P9/10A61P11/00A61P25/28
Inventor 张成飞孟旻
Owner BEIJING BOERDA BIO TECH DEV
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