Voglibose dispersible tablet, capsule and method for preparing the same
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A technology of voglibose and dispersible tablets, which is applied in the field of medicine, can solve the problems of affecting the therapeutic effect of drugs, long drug dissolution time, slow disintegration of ordinary tablets, etc., and achieves favorable dissolution and absorption, short onset time, The effect of convenience
Inactive Publication Date: 2008-07-16
JIANGSU WANBANG BIOPHARMLS +1
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Problems solved by technology
[0004] At present, the dosage form of voglibose on the market at home and abroad is ordinary tablets. The disintegration o
Method used
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Embodiment 1
[0059] Voglibose dispersible tablet comprises the following components by weight percentage:
[0067] (1) Weigh voglibose and auxiliary materials according to the formula and pass through a 100-mesh sieve respectively, and set aside;
[0068] (2) In part of the disintegrant (accounting for 80% of the total amount) and the diluent, add the voglibose of the formula dosage, and mix well;
[0069] (3) Add binder and mix to make soft material, granulate with 18-24 mesh sieve, and dry the granules at 50-80°C;
[0070] (4) arrange with 20 mesh sieves after particle drying;
[0071] (5) Add the rest of the disintegrant (accounting for 20% of the total amount), and mix the lubrica...
Embodiment 2
[0074] Preparation method is identical with embodiment 1, just formula is different, comprises following component by weight percentage:
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Abstract
The invention relates to a voglibose dispersible tablet and capsule and a preparation method thereof. The voglibose dispersible tablet comprises: 0.01-5 percent of voglibose, 1-99 percent of disintegrating agent, 0-98 percent of diluting agent; 0.5-20 percent of lubricant and fluidizer, 0.1-20 percent of bonding agent; wherein, the disintegrating agent is one or more selected from starch, modified starch, cellulose, microcrystalline cellulose, cross-linked polyvinyl pyrrolidone, sodium carboxymethyl starch, cross-linked sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, alginic acid and colloid magnesium aluminum silicate; the diluting agent is one or more selected from lactose, mannitol, sorbitol, sucrose, calcium sulfate, kaolin, dextrine and sodium chloride. The capsule preparation does not contain the bonding agent. The invention has the advantages that the voglibose dispersible tablet disintegrates swiftly and disperses evenly, the voglibose dispersible tablet can be disintegrated swiftly into fine particles and scattered evenly after being taken orally, which is beneficial for the dissolution and the absorption of the voglibose dispersible tablet with the short onset time. Disintegrated swiftly in three minutes; after being taken orally, the capsule shell quickly swells and splits, which conceals the discomfort caused by the capsule taken in mouth.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a voglibose dispersible tablet, a capsule and a preparation method thereof. Background technique [0002] Voglibose is a new generation of α-glucosidase inhibitors developed by Takeda Pharmaceutical Co., Ltd. in Japan. Improve the digestion and absorption of carbohydrates to improve postprandial hyperglycemia. It was first launched in Japan under the brand name Basen in 1994, and it is used for the treatment of postprandial blood sugar elevation in diabetes. In addition, this product is combined with pioglitazone to improve glucose tolerance. [0003] The α-glucosidase inhibitors currently on the market mainly include voglibose and acarbose. Compared with acarbose, voglibose has higher activity and lower dosage; Higher selectivity and lower intestinal side effects. The auspicious effect of voglibose is to delay the production and absorption of glucose, so the hypoglycemic ef...
Claims
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