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Dispersible tablet of colloid petcin

A technology of colloidal bismuth pectin and dispersible tablets, applied in the field of bismuth

Inactive Publication Date: 2005-07-06
HUNAN WARRANT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, colloidal bismuth pectin is only available in capsule form

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0064] According to the preparation method disclosed in the description, the present invention has prepared 35 formulations as shown in Table 1. The specific excipients and dosage are shown in Table 1. See Table 1 for the results of detecting its dispersibility according to the method of Chinese Pharmacopoeia (2000 edition).

[0065] Some samples (prepared according to Example 35) were investigated for influencing factors, and the results are shown in Table 2.

[0066] The results show that the colloidal pectin bismuth dispersible tablets provided by the invention meet the requirements of the Chinese Pharmacopoeia (2000 edition) on dispersible tablets.

[0067] Raw materials

Example 1

Example 2

Example 3

Example 4

Example 5

Example 6

Example 7

Colloidal bismuth pectin (calculated as bismuth) (mg)

50

50

50

50

50

50

50

Lactose (mg)

——

90

90

88

83

150

150

...

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PUM

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Abstract

The invention discloses a dispersible tablet of colloid pectin, which comprises (by weight ratio, in mg) colloid pectine bismuth 25-100 (by bismuth), filling agent 60-400, crumbling agent 42-280, flow aid 1-6, lubricant 0.25-5, the filling agent can be selected from lactose, white dextrine, pregelatine starch or / and starch. The crumbling agent can be selected from cross bonding polyvinylpyrrolidone, crystalline cellulose, cross-linked sodium carboxymethylstarch, low substituted methylcellulose propylene glycol ether, sodium carboxymethylstarch, the glidant can be selected from miropowdered silica gel, the lubricant can be selected from magnesium stearate or / and talcum powder.

Description

technical field [0001] The invention relates to a bismuth agent, in particular to a colloidal bismuth pectin bismuth agent. technical background [0002] Colloidal pectin bismuth bismuth is a gastric mucosal protective agent, which forms a stable gel in the gastric acid environment, covers the mucosal surface, isolates the erosive surface and ulcer focus from gastric acid and pepsin, and protects the damaged mucosa Promote the repair and healing of ulcer tissue; stimulate the production of endogenous prostaglandins and epidermal growth factors, accelerate the healing of ulcers and the disappearance of inflammation, and have a certain hemostatic effect. [0003] Dun Wen and Zhou Erfeng 1 studied the effect of colloidal bismuth pectin on experimental gastric and duodenal ulcers in rats. On the rat model of gastroduodenal ulcer, the effect of bismuth pectin against experimental gastroduodenal ulcer was observed, and compared with Dele, the results: (1) The effect of bismuth pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K33/24A61P1/04
Inventor 黄本东
Owner HUNAN WARRANT PHARMA
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