Glonoin Orally disintegrating tablets preparation of and preparing method thereof

Abstract

The invention relates to a nitroglycerin cavity (hypoglossis) disintegrating tablet and a preparation method which mainly adopts water-soluble excipient. When coming across saliva, a disintegrating tablet can be disintegrated rapidly and most of the excipient is dissolved, which can be absorbed into body to recycle by hypoglossis mucosa. The main indigent of the invention is nitroglycerin ethanol solution occupying 10 percent in weight, and the containing weight uses the mixture of lactose and xylitol in every 10g is 0.8 to 0.9ml. The excipient comprises microcrystalline cellulose 101, low-substituted hydroxypropyl cellulose, disintegrant, lactose, xylitol, alcoholic solution of PVP30 and magnesium stearate. The invention adopts a wet method of preparing particle and tablet, combines with blank particle method to mix the blank particles and the particles containing medicine after being made into particles, which changes the traditional method of spraying medicine layer to blank particles and raises the stability of medicine. The pressure of a tabletting machine is adjusted to 1 to 3kg and the disintegration of the pressed tablets is speeded up.

Description

Technical field:

[0001] The invention relates to a pharmaceutical preparation for treating cardiovascular diseases and a preparation method thereof, in particular to a nitroglycerin orally (sublingual) disintegrating tablet preparation and a preparation method thereof. Background technique:

[0002] Heart disease is a common human disease and an important killer of human health. The early manifestation of its onset is angina pectoris. Angina pectoris is a paroxysmal attack, and the pain often gradually increases after it appears, and gradually disappears within 3 to 5 minutes, and rarely exceeds 15 minutes. If it exceeds 15 minutes, the possibility of acute myocardial infarction should be considered. Typical symptoms are squeeze-like or constriction-like pain, accounting for about 60% of angina pectoris patients, often accompanied by anxiety or fear of dying. Atypical symptoms describe the pain as burning or dull pain, but rarely described as needle-like or knife-like pain...

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