Complex acetaminophen vitamin C dispersion tablet and preparing method thereof

A technology for acetaminophen and vitamins, applied in pill delivery, antipyretics, non-central analgesics, etc., can solve the problems of high production environment requirements, complex production process, poor product stability, etc., and achieve high safety , less toxic and side effects, quick effect

Inactive Publication Date: 2004-06-30
严洁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the compound preparation of acetaminophen and vitamin C are generally used alone clinically. Only the French UPSA company combines these two drugs to produce a compound acetaminophen vitamin C effervescent tablet, although this The drug has the advantages of good curative effect and less toxic and side effects, but its production process is complicated, it has high requirements on the production environment, and its product stability is poor. At present, no similar products have come out in China.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Based on 1000 compound paracetamol vitamin C dispersible tablets, weigh 200g of paracetamol and 400g of vitamin C after crushing and sieving through a 200-mesh sieve, and weigh the dried, crushed and sieved through a 150-mesh sieve at the same time. 45g of microcrystalline cellulose, 15g of stevia and 30g of gelatinized starch, these raw and auxiliary materials are placed in a mixer and mixed evenly, and pressed into Φ15mm flakes with a tablet weight of 300-400mg, and then in a swing granulator Granulate with a 20-mesh sieve; place the granules in a swing granulator and use a 16-mesh sieve for granulation to remove oversized particles, then add 10 g of sodium carboxymethyl starch that has been dried, crushed and screened through a 150-mesh sieve And 5g magnesium stearate and mix homogeneously, at last the tablet weight calculated by the qualified granules according to the measured granule content is compressed on a tablet machine and made into 1000 compound paracetamol v...

Embodiment 2

[0013] Based on 1000 compound paracetamol vitamin C dispersible tablets, weigh 400g of paracetamol and 200g of vitamin C after crushing and sieving through a 200-mesh sieve, and weigh the dried, crushed and sieved through a 150-mesh sieve at the same time. 50g of mannitol, 30g of sucrose and 30g of povidone, these raw and auxiliary materials are placed in a mixer and mixed evenly, and pressed into Φ15mm flakes with a tablet weight of 300-400mg, and then used in a swing granulator with a 20-mesh Sieve granulation; place the granules in a swing granulator and use a 16-mesh sieve for sizing to remove oversized particles, then add 5g of hydroxypropyl starch and 5g of stearin that have been dried, crushed and sieved through a 150-mesh sieve Magnesium acid and mixed evenly, finally the tablet weight calculated by the qualified granules according to the measured granule content is compressed on a tablet machine to make 1000 compound paracetamol vitamin C dispersible tablets.

Embodiment 3

[0015] Based on 1000 pieces of compound paracetamol vitamin C dispersible tablets, weigh 330g of paracetamol and 200g of vitamin C which were crushed and screened through a 200-mesh sieve, and weighed at the same time after being dried, crushed and screened through a 150-mesh sieve 10g of lactose, 10g of aspartame and 30g of povidone, these raw and auxiliary materials are placed in a mixer and mixed evenly, and pressed into Φ15mm flakes with a tablet weight of 300-400mg, and then used in a swing granulator Granulate with a 20-mesh sieve; place the granules in a swinging granulator and use a 16-mesh sieve for sizing to remove oversized particles, then add 45g of low-substituted hydroxypropyl fiber that has been dried, crushed and screened through a 150-mesh sieve Su and 5g magnesium stearate and mix homogeneously, finally the tablet weight calculated by the qualified granules according to the measured granule content is compressed on a tablet machine to make 1000 compound parace...

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Abstract

The present invention relates to compound paracetamol vitamin C disperser tablet and its preparation method. It is formed from paracetamol, vitamin C, disintegrant, filling agent, correctives, adhesive and lubricating agent according to the ratio of 200-400:200-400:1-60:1-100:1-60:2-50:1-10. The disintegrant is carboxy methyl starch sodium, hydroxypropyl starch, low-substituted hydroxypropyl cellulose, calcium cellulose glycollate, cross-linked sodium cellulose glycollate, sodium lauryl sulfate, and the filling agent is lactose, mannitol, sorbyl alcohol, starch, modified starch, beta-dextrin, calcium sulfate dihydrate, microcrystal cellulose, and the corrective is wintergreen oil, peperitol, aspatan, citric acid, cane sugar, sterioside, the adhesive is polyvidone, hydroxypropyl cellulose, gelling starch and ethyl cellulose, and the lubricating agent is magnesium stearate, calcium stearate, polyglycol 6000 and talcum powder.

Description

technical field [0001] The invention relates to a medicine and a manufacturing method thereof, in particular to a compound acetaminophen vitamin C dispersible tablet and a manufacturing method thereof. Background technique [0002] Acetaminophen is a commonly used aniline antipyretic and analgesic drug. It is non-irritating to the stomach, and patients will not have allergic reactions and accumulated poisoning after taking it. It is mostly used clinically to treat headaches, fever and relieve mild to moderate pain. , such as headache, migraine, dysmenorrhea, muscle pain, joint pain, neuralgia, etc. It is also suitable for the treatment of headache, fever and general malaise caused by the common cold and viral infection. effective pain reliever. Vitamin C can enhance the body's resistance to infectious diseases, promote antibody formation, increase leukocyte phagocytosis, anti-inflammatory and anti-allergic effects, and can increase the body's resistance to viruses and the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/375A61P29/00A61P31/00
Inventor 严洁
Owner 严洁
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