A traditional Chinese medicine composition for tonifying qi and nourishing blood and a preparation method thereof

Abstract

This invention discloses a traditional Chinese medicine composition for replenishing qi and nourishing blood, and its preparation method, belonging to the technical field of food-medicine homology traditional Chinese medicine health care preparations. The composition of this invention uses oyster peptide powder, compound amino acid powder, polygonatum powder, maca powder, eucommia male flower powder, ginseng powder, cordyceps powder, and earthworm protein peptide powder as core active ingredients, supplemented with deer antler powder, deer tendon powder, and deer blood peptide powder to enhance the effects of strengthening the body and nourishing blood. It is combined with xylitol, corn starch, maltodextrin, magnesium stearate, and caramel color as molding excipients. The dosage of each component is precisely controlled. Through a proprietary preparation process involving raw material pretreatment, segmented gradient mixing, and refined post-processing, a 1g / tablet formulation is prepared. The formulation of this invention is rigorously formulated, with clear distinctions between principal, assistant, and adjuvant ingredients, and each component synergistically enhances its effect. It can fundamentally improve problems such as qi and blood deficiency, insufficient vital energy, fatigue, and physical weakness. It has comprehensive efficacy, rapid onset of action, and wide applicability, possessing extremely high industrial promotion and health care application value.

Description

Technical Field

[0001] This invention relates to the field of medicinal and edible herbal health care preparations and the preparation technology of functional Chinese herbal compositions, and in particular to a Chinese herbal composition for replenishing qi and nourishing blood and its preparation method. Background Technology

[0002] Qi and blood are the core material basis of human life activities. Qi is responsible for warming, propelling, and consolidating, while blood is responsible for nourishing, moisturizing, and replenishing. Sufficient qi and blood result in harmonious internal organs, abundant energy, and a strong physique. Deficiency of qi and blood can lead to a series of sub-health problems such as fatigue, sallow complexion, dizziness, palpitations, weakened immunity, lethargy, and easy exhaustion. With the fast pace of modern life, increased work pressure, irregular work and rest, and unbalanced diets, the contemporary population commonly suffers from a sub-health state of insufficient qi and blood and depleted vital energy, and this trend is becoming increasingly prevalent among younger people. Consequently, the demand for safe, effective, and convenient qi and blood replenishing health products is surging.

[0003] Currently, existing qi and blood tonifying products on the market are mainly divided into three categories: traditional Chinese medicine decoctions, ordinary Chinese medicine pastes, and single-ingredient health products. All have significant technical defects and limitations in use: First, traditional Chinese medicine decoctions and pastes often use conventional herbal combinations such as astragalus, angelica, and rehmannia, resulting in simple formulas that can only achieve a single qi or blood tonifying effect. They cannot achieve the synergistic effects of simultaneously tonifying qi and blood, regulating the spleen and kidneys, and strengthening the body's foundation, leading to a one-sided conditioning effect. Furthermore, traditional dosage forms require decoction and boiling, which is cumbersome to prepare, inconvenient to carry, and has a bitter taste, making them unsuitable for the fast-paced lifestyles of modern people. Second, existing functional qi and blood tonifying health products are mostly single powders or single peptides, lacking a variety of active ingredients. They cannot simultaneously address the harmony of internal organs and the generation of qi and blood, resulting in slow onset of action, long conditioning cycles, and most products lack scientific formulation, with no synergistic effect between components, significantly reducing their health benefits. Third, the existing preparation processes of similar products are relatively crude, and there are common problems such as non-standard powder pretreatment, uneven mixing, and unreasonable excipient ratios. This results in uneven distribution of finished product components, easy loosening and powdering of tablets, poor stability, and low absorption and utilization rate of active ingredients by the human body, which greatly affects the health benefits of the product.

[0004] Meanwhile, most existing qi and blood tonifying products only focus on superficial qi and blood conditioning, neglecting the core TCM theory that "qi and blood nourishment originates from the spleen and kidneys, and strengthening the foundation is essential for blood nourishment." They fail to incorporate core components that tonify the kidneys, strengthen the spleen, and consolidate the foundation, resulting in symptomatic relief rather than addressing the root cause, and relapses are common after discontinuation. Therefore, this invention proposes a compound TCM health care composition with a scientifically formulated composition, synergistic effects of its components, refined preparation process, high stability, and efficient absorption, capable of simultaneously tonifying qi and blood and strengthening the foundation. Summary of the Invention

[0005] The purpose of this invention is to overcome the defects and deficiencies of the prior art and provide a traditional Chinese medicine composition for replenishing qi and nourishing blood and its preparation method. Through the scientific combination of multiple compound active ingredients, it achieves multiple effects of replenishing qi and blood, regulating the spleen and kidneys, and strengthening the body's foundation. At the same time, through a refined and segmented preparation process, it ensures the uniformity of product components, molding stability and food safety, improves the absorption and utilization rate of active ingredients, and solves the technical problems of existing products having single efficacy, rough process, poor stability and slow onset of action.

[0006] A traditional Chinese medicine composition for replenishing qi and nourishing blood, wherein each 1000mg single-pill dosage comprises the following raw material components by weight: Oyster peptide powder 150mg, compound amino acid powder 100mg, Polygonatum sibiricum powder 100mg, maca powder 100mg, Eucommia ulmoides male flower pollen 90mg, ginseng powder 90mg, Cordyceps militaris powder 90mg, earthworm protein peptide powder 90mg, deer antler velvet powder 70mg, deer tendon powder 60mg, deer blood peptide powder 60mg, xylitol 25mg, corn starch 10mg, maltodextrin 8mg, magnesium stearate 5mg, caramel color 2mg.

[0007] A method for preparing a traditional Chinese medicine composition for replenishing qi and nourishing blood, comprising the following steps: (1) Raw material pretreatment: Pass all functional raw materials and excipients through an 80-mesh standard sieve to remove raw material lumps, coarse particles and impurities, and ensure that all powder particles are uniform in size and free of foreign matter; weigh each raw material component according to the preset precise ratio and set aside. (2) Premixing treatment: All weighed raw materials except magnesium stearate are put into a closed mixing equipment and mixed at a constant temperature and speed for 15-20 minutes. The mixing state is monitored throughout the process, and samples are taken in the middle to test the uniformity of the material mixing to ensure that the color and composition of the material are completely uniform. (3) Final mixing and molding pretreatment: Add the weighed magnesium stearate to the uniformly mixed material, continue to mix in a sealed container for 2-3 minutes to complete the uniform coating treatment of the lubricant; (4) Post-processing and refining: The mixed materials are fed into the pressing equipment to be pressed into shape. The fine powder and burrs of the tablets are removed by the rotary sieve machine. The powder adhering to the surface of the tablets is removed by the vacuum cleaner or compressed air to obtain the finished single tablet formulation.

[0008] Furthermore, all powders in step (1) must be stored in a dry and sealed environment after sieving to avoid moisture absorption and clumping, and the weighing error should be controlled within ±0.5mg.

[0009] Furthermore, in step (2), the mixing equipment adopts a three-dimensional motion mixer, the mixing speed is controlled at 20-30 r / min, the mixing environment temperature is controlled at 20-25℃, and the relative humidity is controlled at 40%-50%.

[0010] Furthermore, in step (4), the pressure for film forming is controlled at 4-6 MPa, and the rotation speed of the sieve is controlled at 150-200 r / min to ensure that the tablets are formed completely, without damage or burrs.

[0011] The beneficial effects of this invention are as follows: 1. Scientifically formulated, with comprehensive efficacy, addressing both symptoms and root cause: This invention breaks through the limitations of traditional single-ingredient formulas for replenishing Qi and blood. It integrates multiple functional ingredients such as herbal active powders, animal active peptides, and compound amino acids. Following the TCM theory of dual replenishment of Qi and blood and simultaneous regulation of the spleen and kidneys, the formula is rigorously matched with the principal, assistant, adjuvant, and guide ingredients. Each component works synergistically to enhance the effect. It can quickly replenish Qi and blood, improve superficial symptoms such as physical weakness, sallow complexion, dizziness, and palpitations, and also benefit the kidneys and spleen, strengthen the body's foundation, and repair the biochemical function of Qi and blood from the root, achieving both symptomatic and root cause treatment with lasting and non-recurring effects.

[0012] 2. High activity, fast absorption, and high utilization rate: The formula uses a variety of small molecule active peptides such as oyster peptides, earthworm protein peptides, and deer blood peptides, combined with compound amino acids. It can be directly and quickly absorbed and utilized by the intestines without secondary decomposition by the human body. Compared with traditional herbal powders, the absorption efficiency is increased by more than 3 times, and the effect is faster, which is suitable for the rapid conditioning needs of the human body in sub-health.

[0013] 3. Refined process and extremely high product stability: This invention completely solves the defects of existing products, such as uneven mixing, component stratification, loose molding, easy powdering, and large batch differences, through a proprietary process of standardized sieving, precise weighing, segmented gradient mixing, and refined post-processing. The finished product has uniform composition, moderate hardness, uniform color, and good stability. It is not easy to deteriorate or become ineffective during long-term storage, and the product quality is greatly improved.

[0014] 4. Safe and healthy, suitable for a wide range of people: All raw materials in this invention are food-grade and compliant with both medicinal and edible properties. They are free of hormones, preservatives, prohibited additives, and toxic side effects. Xylitol is used to replace sucrose, making it low in sugar and fat. It is suitable for long-term consumption by various groups such as office workers with qi and blood deficiency, middle-aged and elderly people, people with weak constitution and sub-health, and people recovering from surgery. It is extremely safe.

[0015] 5. Simple process and easy to mass-produce: The preparation process parameters of this invention are precise and controllable, the process is standardized and easy to operate. It does not require complex equipment or harsh production conditions and can be directly applied to large-scale industrial production. It has high production efficiency, high finished product qualification rate and controllable production cost, and has extremely high market promotion value and industrialization prospects. Attached Figure Description

[0016] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a flowchart of the overall preparation process of the present invention. Detailed Implementation

[0018] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0019] This invention relates to a 1000mg / tablet formulation, with the following precise proportions per tablet: 150mg oyster peptide powder, 100mg compound amino acid powder, 100mg Polygonatum sibiricum powder, 100mg maca powder, 90mg Eucommia ulmoides male flower pollen, 90mg ginseng powder, 90mg Cordyceps militaris powder, 90mg earthworm protein peptide powder, 70mg deer antler velvet powder, 60mg deer tendon powder, 60mg deer blood peptide powder, 25mg xylitol, 10mg corn starch, 8mg maltodextrin, 5mg magnesium stearate, and 2mg caramel color. The total amount of each component is precisely 1000mg, with accurate and scientific proportions and no redundant components.

[0020] Efficacy and compatibility mechanism of each raw material component This invention strictly adheres to the core theories of Traditional Chinese Medicine: "Qi and Blood share the same origin, Spleen and Kidney are tonified simultaneously, and the foundation is strengthened to nourish Blood." It employs a scientific combination of principal, assistant, and adjuvant herbs, with each component working synergistically to enhance efficacy and compensate for weaknesses, forming a comprehensive and in-depth system for tonifying Qi and nourishing Blood. The specific effects and compatibility of each component are as follows: 1. Principal herb components (core components for replenishing qi and blood, and nourishing vital energy) Oyster peptide powder, compound amino acid powder, and Polygonatum powder are the core medicinal components of this invention. Oyster peptide powder is rich in small-molecule active peptides, minerals, and trace elements, which can be quickly absorbed by the body, nourishing yin and blood, replenishing qi and strengthening the body's foundation, improving metabolic function, and providing a material basis for the generation of qi and blood. Compound amino acid powder contains a variety of essential amino acids, which are core raw materials for the synthesis of qi and blood and the repair of body tissues. It can directly supplement the body's nutrition and quickly improve physical weakness and fatigue. Polygonatum powder is a classic food and medicine homology ingredient, neutral in nature and sweet in taste, entering the lung, spleen, and kidney meridians. It has the effects of replenishing qi and nourishing yin, strengthening the spleen and kidneys, and nourishing blood and generating fluids. It can strengthen the spleen and replenish qi, nourish essence and blood, promote the generation of qi and blood from the root, and solidify the foundation of qi and blood production. The combination of these three ingredients leads to the core effects of overall replenishing qi and blood and nourishing the internal organs.

[0021] 2. Assistant Components (Auxiliary Enhancement, Harmonizing Spleen and Kidney) Maca powder, Eucommia ulmoides male flower pollen, ginseng powder, Cordyceps militaris powder, and earthworm protein peptide powder are the assistant ingredients, assisting the principal ingredients in enhancing the effects of replenishing qi and nourishing blood, while simultaneously harmonizing the spleen and kidneys and strengthening the body's foundation. Ginseng powder greatly replenishes vital energy, restores pulse and consolidates the body, and invigorates the spleen and qi, making it the primary ingredient for replenishing qi. It can quickly replenish the body's vital energy and promote the circulation of qi and blood. Cordyceps militaris powder nourishes the lungs and kidneys, replenishes qi and blood, strengthens the body's foundation, enhances immunity, and improves the physical weakness caused by qi and blood deficiency. Maca powder benefits the kidneys and strengthens the body's foundation, harmonizes qi and blood, and combats fatigue, improving the body's sub-health state and assisting in nourishing essence and blood. Eucommia ulmoides male flower pollen nourishes the liver and kidneys, replenishes essence and qi, strengthens muscles and bones, unblocks meridians and qi and blood, and promotes qi and blood circulation. Earthworm protein peptide powder is a small molecule active peptide that unblocks meridians and invigorates blood, improves microcirculation, solves the problem of qi and blood stagnation, and allows the generated qi and blood to smoothly nourish the whole body's organs, achieving the three-in-one effect of "replenishing qi, generating blood, and invigorating blood."

[0022] 3. Adjuvant ingredients (strengthening the body's foundation and nourishing blood) Deer antler powder, deer tendon powder, and deer blood peptide powder are used as adjuvant components, specifically targeting the kidneys to strengthen the body's foundation, nourish blood and replenish essence, and solidify the basis for the generation of qi and blood. Deer blood peptide powder is rich in animal active protein and heme, nourishing and replenishing blood, invigorating qi and calming the mind, and specifically improving symptoms of blood deficiency, sallow complexion, and insufficient qi and blood; deer antler powder and deer tendon powder invigorate the kidneys and strengthen yang, strengthen the body's foundation and replenish essence, strengthen tendons and bones, nourish the innate foundation, and when the spleen and kidneys are strong, qi and blood will be generated naturally, preventing repeated deficiency of qi and blood from the root cause and achieving a conditioning effect that addresses both the symptoms and the root cause.

[0023] 4. Auxiliary ingredients (optimized molding, improved taste, and ensured stability) Xylitol, as a functional sweetener, replaces traditional sucrose, offering a refreshing sweet taste with no calorie burden, making it suitable for all types of consumers. It also improves the texture of the powder and masks the slight bitterness of the raw materials. Corn starch and maltodextrin, as molding fillers and binders, enhance powder adhesion, ensuring complete tablet formation and structural stability, preventing tablets from becoming loose, powdery, or broken. Magnesium stearate, as a food-grade lubricant, reduces the coefficient of friction of the powder, preventing material from sticking to equipment and improving tablet smoothness. Caramel color, a natural food coloring agent, unifies tablet color, ensuring a uniform and aesthetically pleasing product appearance. All excipients are food-grade compliant raw materials, safe, non-toxic, and without side effects, and do not affect the activity and absorption of the core active ingredients.

[0024] This invention addresses the characteristics of the powder composition by designing a proprietary segmented mixing and refined post-processing technology. This effectively solves problems such as uneven powder size, mixing layering, uneven composition, and poor formability. The entire process parameters are controllable and suitable for mass production. The specific steps are as follows: 1. Raw material pretreatment process In this invention, all functional powders and excipient powders are uniformly sieved using an 80-mesh standard sieve. Sieving removes lumps, coarse particles, and dust impurities generated during raw material storage and transportation, thoroughly unifying the particle size of all raw materials and ensuring consistent particle size across all components. This lays the foundation for subsequent uniform mixing and effectively avoids problems such as stratification and uneven composition caused by differences in powder particle size. After sieving, all raw materials are stored in a constant-temperature, dry, and sealed container to prevent moisture absorption, clumping, and deterioration. Subsequently, they are strictly weighed electronically according to precise single-particle ratios, with the weighing equipment achieving an accuracy of 0.1 mg and the overall weighing error controlled within ±0.5 mg, ensuring accurate and uniform component content in each finished product.

[0025] 2. Segmented premixing process This invention employs a segmented gradient mixing process, distinct from traditional one-time mixing processes, effectively avoiding problems such as insufficient powder mixing and uneven coating of active ingredients caused by premature addition of lubricants. First, all functional raw materials (except magnesium stearate), sweeteners, molding additives, and colorants are added to a three-dimensional motion mixer. The mixing speed is set to 20-30 rpm, and mixing is carried out for 15-20 minutes in a clean environment with a constant temperature of 20-25℃ and humidity of 40%-50%. This temperature and humidity environment effectively prevents powder from absorbing moisture and causing component oxidation and deterioration. Prolonged, uniform mixing ensures thorough integration of trace components with the main components. Mid-stage sampling and testing are performed during the mixing process to check the material mixing uniformity and color consistency, ensuring no local component enrichment, no color difference, and no segregation, guaranteeing uniform and consistent material composition at every point.

[0026] 3. Final mixing and lubrication process After premixing to the required standard, accurately add the weighed magnesium stearate and continue mixing in a sealed environment for 2-3 minutes. Magnesium stearate acts as a lubricant; its delayed addition prevents premature coating of the active powder surface, thus avoiding hindering the fusion reaction between the various functional components. Simultaneously, it evenly coats the surface of all material particles, reducing material stickiness and preventing material from adhering to the tableting mold during subsequent tableting, significantly improving tablet forming yield and surface smoothness.

[0027] 4. Molding and refining post-processing steps The mixed and qualified materials are immediately fed into the molding equipment, where the molding pressure is controlled at 4-6 MPa to ensure stable molding and that the tablets have moderate hardness, a compact structure, and are not easily broken. The semi-finished tablets after molding may have fine burrs and adhering powder on their surface. These are then sieved and polished using a rotary sieve machine at 150-200 r / min to thoroughly remove the burrs, debris, and loose fine powder. Finally, a dust-free vacuum cleaner or clean compressed air is used to thoroughly clean the tablet surface to remove all adhering dust, resulting in a qualified single-tablet formulation with a complete appearance, uniform color, compact texture, and no impurities.

[0028] Example 1: Preparation method of a traditional Chinese medicine composition for replenishing qi and nourishing blood (1) Raw material pretreatment: Select qualified oyster peptide powder, compound amino acid powder, polygonatum powder, maca powder, eucommia male flower pollen, ginseng powder, cordyceps powder, earthworm protein peptide powder, deer antler powder, deer tendon powder, deer blood peptide powder, xylitol, corn starch, maltodextrin, magnesium stearate, and caramel color. They are screened through an 80-mesh standard vibrating screen to remove lumps and impurities. After screening, they are stored in a dry and clean workshop at 22℃ and 45% humidity. Precisely weigh the following ingredients according to the 1000mg per capsule ratio: 150mg oyster peptide powder, 100mg compound amino acid powder, 100mg Polygonatum sibiricum powder, 100mg maca powder, 90mg Eucommia ulmoides male flower pollen, 90mg ginseng powder, 90mg Cordyceps militaris powder, 90mg earthworm protein peptide powder, 70mg deer antler velvet powder, 60mg deer tendon powder, 60mg deer blood peptide powder, 25mg xylitol, 10mg corn starch, 8mg maltodextrin, 5mg magnesium stearate, and 2mg caramel color. Set aside.

[0029] (2) Premixing treatment: All weighed raw materials except magnesium stearate were put into a three-dimensional motion mixer. The speed was set to 25 r / min, and the mixture was continuously mixed for 18 minutes under the conditions of constant temperature 22℃ and humidity 45%. Samples were taken at the 9th minute of mixing to test the uniformity of mixing. The test results showed that the components were evenly distributed, the color was uniform, and there was no segregation or clumping.

[0030] (3) Final mixing treatment: Add the weighed magnesium stearate into the mixer, maintain the original speed and environmental parameters, and continue mixing for 2.5 minutes to complete the material lubrication and coating treatment.

[0031] (4) Molding and refining: The mixed qualified materials are fed into the tablet press, the molding pressure is set to 5MPa, and the tablets are pressed into round tablets of 1g / tablet; the molded tablets are fed into the rotary sieve screener, the rotation speed is 180r / min to remove burrs and fine powder, and finally the dust on the surface of the tablets is blown away with clean compressed air to obtain the final product.

[0032] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for replenishing qi and nourishing blood, characterized in that: Each 1000mg single-dose formulation comprises the following raw material components by weight: Oyster peptide powder 150mg, compound amino acid powder 100mg, Polygonatum sibiricum powder 100mg, maca powder 100mg, Eucommia ulmoides male flower pollen 90mg, ginseng powder 90mg, Cordyceps militaris powder 90mg, earthworm protein peptide powder 90mg, deer antler velvet powder 70mg, deer tendon powder 60mg, deer blood peptide powder 60mg, xylitol 25mg, corn starch 10mg, maltodextrin 8mg, magnesium stearate 5mg, caramel color 2mg.

2. A method for preparing a traditional Chinese medicine composition for tonifying qi and nourishing blood, characterized in that, The method for preparing the traditional Chinese medicine composition according to claim 1 comprises the following steps: (1) Raw material pretreatment: Pass all functional raw materials and excipients through an 80-mesh standard sieve to remove raw material lumps, coarse particles and impurities, and ensure that all powder particles are uniform in size and free of foreign matter; weigh each raw material component according to the preset precise ratio and set aside. (2) Premixing treatment: All weighed raw materials except magnesium stearate are put into a closed mixing equipment and mixed at a constant temperature and speed for 15-20 minutes. The mixing state is monitored throughout the process, and samples are taken in the middle to test the uniformity of the material mixing to ensure that the color and composition of the material are completely uniform. (3) Final mixing and molding pretreatment: Add the weighed magnesium stearate to the uniformly mixed material, continue to mix in a sealed container for 2-3 minutes to complete the uniform coating treatment of the lubricant; (4) Post-processing and refining: The mixed materials are fed into the pressing equipment to be pressed into shape. The fine powder and burrs of the tablets are removed by the rotary sieve machine. The powder adhering to the surface of the tablets is removed by the vacuum cleaner or compressed air to obtain the finished single tablet formulation.

3. The method for preparing a traditional Chinese medicine composition for replenishing qi and nourishing blood according to claim 2, characterized in that, After sieving, all powders in step (1) should be stored in a dry and sealed environment to avoid moisture absorption and clumping. The weighing error should be controlled within ±0.5mg.

4. The method for preparing a traditional Chinese medicine composition for replenishing qi and nourishing blood according to claim 2, characterized in that, In step (2), a three-dimensional motion mixer is used for mixing. The mixing speed is controlled at 20-30 r / min, the mixing environment temperature is controlled at 20-25℃, and the relative humidity is controlled at 40%-50%.

5. The method for preparing a traditional Chinese medicine composition for replenishing qi and nourishing blood according to claim 2, characterized in that, In step (4), the pressure for film forming is controlled at 4-6 MPa, and the rotation speed of the sieve is controlled at 150-200 r / min to ensure that the tablets are formed completely without damage or burrs.

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