Lushenkangyuan brand tea polyphenol, grape seed and American ginseng capsule helpful for resisting oxidation

Abstract

The invention relates to the technical field of health-care food, in particular to a Lushenkangyuan brand tea polyphenol, grape seed and American ginseng capsule helpful for resisting oxidation. Comprising the following compositions in percentage by weight: 20%-30% of tea polyphenol, 15%-25% of a grape seed extract, 10%-20% of an American ginseng extract, 10%-15% of dextrin and 0.01%-0.05% of magnesium stearate, and the total content of the tea polyphenol, the grape seed extract and the American ginseng extract is 45%-75%. According to the present invention, the effects of scientific formula, high active component content, clear dual anti-oxidation mechanism, and significant synergistic effect among the components are achieved.

Description

Technical Field

[0001] This invention relates to the field of health food technology, and in particular to Lu Sheng Kang Yuan brand tea polyphenol grape seed ginseng capsules that help with anti-oxidation. Background Technology

[0002] Oxidative stress is a physiological state caused by an imbalance between the production and clearance of reactive oxygen species (ROS) in the body, leading to an excessive accumulation of free radicals and causing cell damage. It is a core pathological mechanism of aging and various chronic diseases such as cardiovascular disease, neurodegenerative diseases, diabetes, and cancer. Currently, supplementing with exogenous antioxidants to neutralize excess free radicals is the mainstream strategy for clinical and daily intervention of oxidative stress.

[0003] There are numerous commercially available antioxidant health products, with core active ingredients mainly including vitamin C, vitamin E, selenium, beta-carotene, coenzyme Q10, and lycopene. However, single antioxidant ingredients suffer from limitations such as limited target sites, low bioavailability, and poor stability. Existing compound antioxidant products are mostly simple additives of active ingredients, lacking scientific guidance based on synergistic effects. They also generally suffer from low levels of active ingredients and excessively high proportions of excipients, resulting in insufficient intake of actual effective components and failing to achieve the desired antioxidant effect. Tea polyphenols, grape seed extract (rich in proanthocyanidins), and American ginseng extract (rich in ginsenosides) are all recognized as natural and highly effective antioxidants, but their application in compound products remains largely conceptual. In existing technologies, there are few studies that disclose how to combine these three ingredients in specific content ranges and ratios to systematically construct a dual synergistic mechanism of "directly scavenging free radicals" and "activating the endogenous antioxidant defense system." At the same time, existing technologies have not solved the technical challenge of ensuring product stability, uniformity, and industrial manufacturability while significantly increasing the total proportion of core active ingredients.

[0004] In summary, we propose a scientifically formulated, high-content active ingredient capsule containing Lu Sheng Kang Yuan brand tea polyphenols, grape seed, and American ginseng, which has a clear dual antioxidant mechanism and significant synergistic effects among its components, thus contributing to antioxidant activity. Summary of the Invention

[0005] The purpose of this invention is to provide a Lu Sheng Kang Yuan brand tea polyphenol grape seed ginseng capsule that helps with anti-oxidation, achieving the goals of scientific formulation, high content of active ingredients, clear dual anti-oxidation mechanism, and significant synergistic effect among the components.

[0006] To achieve the above objectives, the present invention provides a Lu Sheng Kang Yuan brand tea polyphenol grape seed and American ginseng capsule that helps with anti-oxidation, comprising the following composition by weight percentage: 20%~30% tea polyphenols, 15%~25% grape seed extract, 10%~20% American ginseng extract, 10%~15% dextrin, 0.01%~0.05% magnesium stearate, and the total content of tea polyphenols, grape seed extract and American ginseng extract is 45%~75%.

[0007] The weight ratio of tea polyphenols, grape seed extract, and American ginseng extract is 20~30:15~25:10~20.

[0008] Among them, tea polyphenols are green tea extracts with a total catechin content of ≥80%, grape seed extract is a standardized extract with a proanthocyanidin content of ≥95%, and American ginseng extract is a standardized extract with a total saponin content of ≥80%.

[0009] Each 100g of the composition contains 20-30g of tea polyphenols, 14.25-23.75g of proanthocyanidins, and 8-16g of total saponins.

[0010] Each capsule contains 300-500mg of fluid.

[0011] The present invention discloses a Lu Sheng Kang Yuan brand tea polyphenol grape seed and American ginseng capsule that helps with antioxidation, comprising the following composition by weight percentage: 20%~30% tea polyphenols, 15%~25% grape seed extract, 10%~20% American ginseng extract, 10%~15% dextrin, and 0.01%~0.05% magnesium stearate, wherein the total content of tea polyphenols, grape seed extract and American ginseng extract is 45%~75%. Through the above, the product achieves the effects of scientific formulation, high content of active ingredients, clear dual antioxidant mechanism and significant synergistic effect among components. Attached Figure Description

[0012] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0013] Figure 1 This is a flowchart illustrating the steps involved in the development of Lu Sheng Kang Yuan brand tea polyphenol grape seed and American ginseng capsules, which are beneficial for antioxidant effects, according to the present invention. Detailed Implementation

[0014] Exemplary embodiments will now be described in detail, examples of which are illustrated in the accompanying drawings. When the following description relates to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with this application.

[0015] The terminology used in this application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The singular forms “a,” “the,” and “the” used in this application and the appended claims are also intended to include the plural forms unless the context clearly indicates otherwise. It should also be understood that the term “and / or” as used herein refers to and includes any or all possible combinations of one or more of the associated listed items.

[0016] It should be understood that although the terms first, second, third, etc., may be used in this application to describe various information, such information should not be limited to these terms. These terms are only used to distinguish information of the same type from one another. For example, without departing from the scope of this application, first information may also be referred to as second information, and similarly, second information may also be referred to as first information. Depending on the context, the word "if" as used herein may be interpreted as "when," "when," or "in response to determination."

[0017] This invention provides a Lu Sheng Kang Yuan brand tea polyphenol grape seed ginseng capsule that helps with anti-oxidation, comprising the following composition by weight percentage: 20%~30% tea polyphenols, 15%~25% grape seed extract, 10%~20% American ginseng extract, 10%~15% dextrin, 0.01%~0.05% magnesium stearate, and the total content of tea polyphenols, grape seed extract and American ginseng extract is 45%~75%.

[0018] Furthermore, the weight ratio of tea polyphenols, grape seed extract, and American ginseng extract is 20~30:15~25:10~20.

[0019] Furthermore, the weight percentages of tea polyphenols, grape seed extract, and American ginseng extract are 25%, 20%, and 15%, respectively.

[0020] Furthermore, the tea polyphenols are green tea extracts with a total catechin content of ≥80%, the grape seed extract is a standardized extract with a proanthocyanidin content of ≥95%, and the American ginseng extract is a standardized extract with a total saponin content of ≥80%.

[0021] Furthermore, each 100g of the composition contains 20-30g of tea polyphenols, 14.25-23.75g of proanthocyanidins, and 8-16g of total saponins.

[0022] Furthermore, each capsule contains 300-500 mg.

[0023] In this embodiment, the compound composition comprises, by weight percentage, 20%–30% tea polyphenols, 15%–25% grape seed extract, 10%–20% American ginseng extract, 10%–15% dextrin, and 0.01%–0.05% magnesium stearate. Tea polyphenols, grape seed extract, and American ginseng extract are the core active ingredients, with a total content of 45%–75%. The weight ratio of tea polyphenols, grape seed extract, and American ginseng extract is 20–30:15–25:10–20. The purity of the raw materials is clearly defined, and the tea polyphenols are catechins. The composition comprises green tea extract with a total polyphenol content ≥80%, grape seed extract with a standardized proanthocyanidin content ≥95%, and American ginseng extract with a standardized total saponin content ≥80%. Based on the purity standards of these raw materials, each 100g of this composition contains 20-30g of tea polyphenols, 14.25-23.75g of proanthocyanidins, and 8-16g of total saponins. The single capsule contains 300-500mg. Through the above, the composition achieves the effects of scientific formulation, high content of active ingredients, a clear dual antioxidant mechanism, and significant synergistic effects among the components.

[0024] Please see Figure 1 The present invention also provides a method for preparing Lu Sheng Kang Yuan brand tea polyphenol grape seed ginseng capsules, which help with anti-oxidation, comprising the following steps: S100: Pass tea polyphenols, grape seed extract and American ginseng extract through an 80-100 mesh sieve respectively; S200: Place the processed tea polyphenols, grape seed extract and American ginseng extract into a three-dimensional motion mixer and premix for 15-25 minutes to obtain a premix; S300: Add the premix and the prescribed amount of dextrin to the mixer and mix for 30-40 minutes to obtain the medium mixture; S400: Add the formulated amount of magnesium stearate to the mixture and mix for 5-10 minutes to obtain the final mixture; S500: The final mixture is filled into gelatin capsule shells using a fully automatic capsule filling machine, with the filling amount controlled at 400mg / capsule ±10%. The capsules are then dispensed, sealed, and labeled to obtain tea polyphenol grape seed ginseng capsules.

[0025] Furthermore, the application of tea polyphenol grape seed ginseng capsules in the preparation of health foods for anti-oxidation, delaying aging and / or reducing oxidative stress damage.

[0026] Furthermore, the recommended daily intake of health food products provides 200-600mg of tea polyphenols, 150-500mg of proanthocyanidins, and 80-300mg of total saponins.

[0027] In this embodiment, tea polyphenols, grape seed extract, and American ginseng extract are first passed through an 80-100 mesh sieve. Then, the processed tea polyphenols, grape seed extract, and American ginseng extract are placed in a three-dimensional motion mixer and premixed for 15-25 minutes to obtain a premix. Next, the premix and the prescribed amount of dextrin are added to the mixer and mixed for 30-40 minutes. Then, the prescribed amount of magnesium stearate is added to the mixture and mixed for 5-10 minutes to obtain a final mixture. Finally, the final mixture is filled into gelatin capsules using a fully automatic capsule filling machine, controlling the fill weight to 400 mg / capsule ± 10%, and then dispensed, sealed, and labeled to obtain the final mixture. Tea polyphenol grape seed ginseng capsules; the tea polyphenol grape seed ginseng capsules obtained from this product can be directly used to prepare health food products with antioxidant, anti-aging and / or oxidative stress-reducing effects. For people who need antioxidant health care, the recommended daily intake of this health food product should meet the following requirements: providing 200~600mg of tea polyphenols, 150~500mg of proanthocyanidins, and 80~300mg of total saponins. The usual way to take it is 1~2 capsules twice a day. It can effectively exert antioxidant effects through the dual mechanism of "exogenous scavenging of free radicals + endogenous activation of antioxidant enzyme system" and slow down the decline of bodily functions caused by oxidative stress.

[0028] Example 1: Formula (by weight): 25% tea polyphenols (85% catechin content), 20% grape seed extract (95% proanthocyanidin content), 15% American ginseng extract (80% total saponins content), 39.98% dextrin, and 0.02% magnesium stearate.

[0029] The preparation method is as follows: Tea polyphenols, grape seed extract and American ginseng extract were dried in an oven at 45°C and humidity <30% for 3 hours and then passed through a 100-mesh sieve.

[0030] The sieved tea polyphenols, grape seed extract and American ginseng extract were put into a three-dimensional mixer (100L capacity) and mixed at 15 rpm for 20 minutes to obtain premix A.

[0031] Add 39.98 kg of dextrin to a mixer containing premix A and continue mixing for 35 minutes to obtain mixture B.

[0032] Add 0.02 kg of magnesium stearate to mixture B and mix for 8 minutes to obtain the final mixture.

[0033] The final mixture is filled into No. 0 transparent capsule shells using a capsule filling machine, with each capsule containing 400mg, thus obtaining capsule product C1.

[0034] Examples 2-4: Compound compositions with different ratios.

[0035] Capsule products C2, C3, and C4 were prepared according to the formulations (weight percentages) shown in Table 1, using the same preparation method as in Example 1, as shown in Table 1.

[0036] Table 1 (Formulation table for Examples 2-4).

[0037] Comparative Example 1: Capsules containing only 30% tea polyphenols, 69.97% dextrin, and 0.03% magnesium stearate.

[0038] Comparative Example 2: A commercially available brand of compound antioxidant capsules containing vitamin C, vitamin E, and grape seed extract.

[0039] Experimental Example 1: Evaluation of in vitro antioxidant activity (DPPH method).

[0040] Different concentrations of sample solutions from Examples C1-C4 and the comparative example were prepared, and their scavenging rate against DPPH free radicals was determined (the smaller the IC50 value, the stronger the activity). The results are shown in Table 2.

[0041] Table 2: DPPH free radical scavenging capacity (IC50, μg / mL).

[0042] Conclusion: The products of the various embodiments of the present invention exhibit significantly better DPPH free radical scavenging ability than single-component products (Comparative Example 1) and commercially available common compound products (Comparative Example 2), proving that the formulation of the present invention has excellent synergistic antioxidant effect.

[0043] Experimental Example 2: In vivo antioxidant effect on a D-galactose-induced aging mouse model.

[0044] Sixty healthy male mice were randomly divided into six groups: a normal control group, a model group, a positive control group (vitamin E), and low, medium, and high dose C1 groups. Except for the normal control group, the remaining groups were subcutaneously injected with D-galactose to establish an aging model. After 6 weeks of gavage administration, the activities of SOD and GSH-Px and the content of MDA in the serum and liver of the mice were measured. The results (taking the medium dose C1 group as an example) showed that compared with the model group, the activities of SOD and GSH-Px in the serum of mice in the medium dose C1 group increased by approximately 58% and 45%, respectively, and the MDA content in the liver decreased by approximately 41%. These effects were significantly better than those in the positive control group (P<0.05) and showed a dose-dependent effect. This confirms that the product of this invention can not only directly scavenge free radicals but also effectively enhance the activity of the body's own antioxidant enzyme system.

[0045] Experimental Example 3: Application.

[0046] The capsules prepared according to this invention (such as C1) are to be taken twice daily, 1-2 capsules each time, for middle-aged and elderly people who require antioxidant health care. This can help slow down the decline in bodily functions caused by oxidative stress and assist in improving related sub-health conditions caused by oxidative damage.

[0047] Other embodiments of this application will readily occur to those skilled in the art upon consideration of the specification and practice of the disclosure herein. This application is intended to cover any variations, uses, or adaptations of this application that follow the general principles of this application and include common knowledge or customary techniques in the art not disclosed herein.

[0048] It should be understood that this application is not limited to the precise structure described above and shown in the accompanying drawings, and various modifications and changes can be made without departing from its scope.

Claims

1. A Lu Sheng Kang Yuan brand tea polyphenol grape seed and American ginseng capsule that helps with anti-oxidation, characterized in that... The composition comprises the following weight percentages: 20%~30% tea polyphenols, 15%~25% grape seed extract, 10%~20% American ginseng extract, 10%~15% dextrin, 0.01%~0.05% magnesium stearate, and the total content of tea polyphenols, grape seed extract and American ginseng extract is 45%~75%.

2. The Lu Sheng Kang Yuan brand tea polyphenol grape seed and American ginseng capsules as described in claim 1, characterized in that, The weight ratio of tea polyphenols, grape seed extract, and American ginseng extract is 20~30:15~25:10~20.

3. The Lu Sheng Kang Yuan brand tea polyphenol grape seed and American ginseng capsules as described in claim 1, characterized in that, Tea polyphenols are green tea extracts with a total catechin content of ≥80%, grape seed extract is a standardized extract with a proanthocyanidin content of ≥95%, and American ginseng extract is a standardized extract with a total saponin content of ≥80%.

4. The Lu Sheng Kang Yuan brand tea polyphenol grape seed and American ginseng capsules as described in claim 3, characterized in that, Each 100g of the composition contains 20-30g of tea polyphenols, 14.25-23.75g of proanthocyanidins, and 8-16g of total saponins.

5. The Lu Sheng Kang Yuan brand tea polyphenol grape seed and American ginseng capsules as described in claim 1, characterized in that, Each capsule contains 300-500mg.

Images