Synthesis method of myricetin

Abstract

The invention discloses a synthesis method of myricetin. The method includes the steps of: adding an alkaline solution into a dihydromyricetin aqueous solution, and then performing heating under a reflux state; adding a selenium dioxide aqueous solution, then stirring at a reflux temperature for reaction, and then performing cooling to room temperature; adding acid to adjust the pH value, conducting stirring and rotary evaporation, and then performing stirring and filtering; adding an ethanol aqueous solution into a filter cake, performing pulping and filtering, flushing the filter cake with an ethanol aqueous solution, collecting the filter cake, and performing drying to obtain red selenium; combining an organic phases, and performing spin-drying till no ethanol smell, precipitating a large amount of solid, performing filtering, and flushing the filter cake with an ethanol aqueous solution to obtain a yellow solid, i.e. myricetin. The method has the advantages that: 1, the reaction issimple and easy to operate; 2, water and a small amount of ethanol are mainly used as the solvent, and the emission of three wastes is low; 3, red selenium with economic value can be recovered; 4, the obtained myricetin is high in purity; and 5, the method can achieve multiple purposes, has very good economic benefits, and is suitable for large-scale production.

Description

technical field [0001] The application relates to the technical field of pharmacy, in particular to a method for synthesizing myricetin. Background technique [0002] Myricetin (myricetin), the molecular formula is C 15 h 10 o 8 , the chemical name is 3,5,7-trihydroxy-2-(3,4,5-hexahydroxyphenyl)-4H-1-benzopyran-4-one, which is widely found in bayberry and other The flavonol compounds in this kind of natural plant have various pharmacological activities such as anti-inflammatory and analgesic, anti-tumor, hypoglycemic, and liver protection, showing rich resource advantages and huge potential utilization value. [0003] At present, the synthesis methods of myricetin are mainly divided into the following types: natural extraction, sodium hydroxide-hydrogen peroxide system oxidation method, sodium hypochlorite-aluminum trichloride / ferric chloride oxidation method, and chemical synthesis using mesitylene as the starting material. synthetic method. [0004] The content of myr...

AI Technical Summary

Problems solved by technology

[0004] The content of myricetin in natural plants is extremely low, it is difficult to extract and enrich, the yield is low, the product purity is difficult to meet the requirements, and the cost is high; the sodium hydroxide-hydrogen peroxide oxidation method directly oxidizes dihydromyricetin to semi-synthesize myricetin, and the yield Only 15-20%, the reaction process is difficult to control, the post-treatment is cumbersome, and it is not suitable for scale-up production; the oxidation of sodium hypochlorite-aluminum trichloride / ferric chloride will produce a large amount of waste water and waste residue, which pollutes the environment and is not suitable for scale-up production; Using mesitylene as the starting material to synthesize myricetin, the cost of raw materials and intermediates is high, a large amount of organic waste liquid will be generated, the yield is low, and it is not suitable for scale-up production