Use of flavonol compound in preparation of antihypoxic medicines or foods

A technology of anti-hypoxic drugs and flavonols, which is applied in application, food preparation, drug combination, etc.

Inactive Publication Date: 2011-10-12
中国人民解放军总后勤部卫生部药品仪器检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, there have been no relevant reports about dihydromyricetin, myricetin, dihydroquercetin and quercetin having anti-hypoxic activity

Method used

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  • Use of flavonol compound in preparation of antihypoxic medicines or foods
  • Use of flavonol compound in preparation of antihypoxic medicines or foods
  • Use of flavonol compound in preparation of antihypoxic medicines or foods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Anti-hypoxic experiment of embodiment 1, dihydromyricetin, myricetin, dihydroquercetin and quercetin

[0022] 1. Experimental drug

[0023] The quercetin standard was provided by the National Institute of Pharmaceutical and Biological Products; the dihydroquercetin standard was provided by Shanghai Yuanye Biotechnology Co., Ltd.; the standard myricetin and dihydromyricetin were provided by Shanghai Tongtian Biotechnology Co., Ltd.

[0024] 2. Cell lines

[0025] The rat cardiomyocyte cell line H9C2 was provided by Shanghai Institute of Cell Biology, Chinese Academy of Sciences.

[0026] 3. Culture medium

[0027] DMEM + 10% fetal bovine serum

[0028] 4. Other materials

[0029]Trypsin (Invitrigen); DMSO (sigma); MTT (sigma); Petri dish (Corning); Pipette (Corning); 96-well plate (Corning); 2 Incubator (SANYO); microplate reader (Biotek76833), etc.

[0030] 5. Test method

[0031] to 10 4 Inoculate a 96-well plate at a concentration of cells / well, 100 μl per wel...

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Abstract

The invention discloses a use of a flavonol compound, which is the use of the flavonol compound in the preparation of antihypoxic medicines, health-care foods or foods. The flavonol compound may be dihydromyricetin, myricetin, dihydroquercetin or quercetin. In the invention, the cell activity test experiment and antihypoxic test of the dihydromyricetin, myricetin, dihydroquercetin and quercetin are performed by adopting a methyl thiazolyl tetrazolium (MTT) method and H9C2 (a rat myocardial cell line). Results show that the four flavonol compounds all have obvious antihypoxic activity and can be used for preparing antihypoxic medicines, health-care products or foods.

Description

technical field [0001] The invention relates to the application of flavonoid alcohol compounds in the preparation of anti-hypoxia medicine or food. Background technique [0002] Dihydromyricetin, Myricetin, Dihydroquercetin and Quercetin are flavonoids with a wide range of sources. [0003] Dihydromyricetin exists in the fruit of Hovinia dulcis Thunb (Hovinia dulcis Thunb) in the rhamnaceae [Seung Mi Yoo, Sungyong Mun, Jin-Hyun Kim. dulcis, Process Biochemistry, 2006(41): 567-570]. Studies have shown that dihydromyricetin has an inhibitory effect on mouse liver glutathione-S-transferase [Yang Xiufen, Yang Ziming. Inhibitory effect of dihydromyricetin on mouse liver glutathione-S-transferase and its kinetic analysis, China Pharmacology Bulletin, 2010; 26(7):894~898]; dihydromyricetin can antagonize detoxification Norepinephrine (NA) and High K + Contraction response of rabbit thoracic aortic strips induced by depolarization 【Zhou Tianda, Zhou Xuexian. Separation, structu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P39/00A23L1/30
Inventor 嵇扬郑悦陈海生杨建周苏萍
Owner 中国人民解放军总后勤部卫生部药品仪器检验所
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