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Application of 7-methoxyl baicalein in preparing anti-hypoxic medicines

An anti-hypoxic drug, a technology of methoxy yellow, applied in the field of medicine, can solve the problems that the biological activity of 7-methoxy baicalein is rarely reported and the like

Active Publication Date: 2014-06-25
中国人民解放军联勤保障部队第九四〇医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few reports on the biological activity of 7-methoxybaicalein

Method used

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  • Application of 7-methoxyl baicalein in preparing anti-hypoxic medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 7-Methoxybaicalein tablet, the composition and content are as follows:

[0045] 7-methoxybaicalein (purity greater than 95%) 50.0g

[0046] Filler 130.0g

[0047] Disintegrant 10.0g

[0048] Adhesive 6.0g

[0049] Lubricant 4.0g

[0050] Total 200. 0g

[0051] Prepared according to the conventional tablet method, and made 1000 tablets in total, each containing 50 mg of 7-methoxybaicalein.

Embodiment 2

[0053] 7-methoxy baicalein capsules, the composition and content are as follows:

[0054] 7-methoxybaicalein (purity greater than 95%) 50.0g

[0055] Filler 135.0g

[0056] Adhesive 5.0g

[0057] Lubricant 10.0g

[0058] Total 200.0g

[0059] Prepared according to the conventional method of capsules, 1000 capsules were made in total, and each capsule contained 50 mg of 7-methoxybaicalein.

Embodiment 3

[0061] 7-Methoxybaicalein dispersible tablet, the composition and content are as follows:

[0062] 7-methoxybaicalein (purity greater than 95%) 50.0g

[0063] Microcrystalline cellulose (MCC) 130.0g

[0064] Croscarmellose Sodium (cCMC-Na) 20.0g

[0065] Total 200.0g

[0066] Prepared according to the conventional method of dispersible tablets, made a total of 1000 tablets, each containing 50 mg of 7-methoxybaicalein.

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Abstract

The invention discloses a novel application of 7-methoxyl baicalein, namely an application in preparing anti-hypoxic medicines. The integral animal hypoxic experiments show that 7-methoxyl baicalein has a remarkable anti-hypoxic activity, and not only can prolong the survival time of a closed hypoxic mouse at a normal pressure, but also can prolong the survival time of an acute decompression hypoxic mouse. The mechanism of action of 7-methoxyl baicalein may be related to effective removal of excessive free radicals generated in hypoxic mouse tissues and improvement of oxidation resistance.

Description

technical field [0001] The invention relates to an application method of 7-methoxybaicalein, which belongs to the field of medicine. Background technique [0002] With the change of people's lifestyle and the accelerated pace of life, hypoxia has become a fairly common pathological process. The plateau area is a typical hypoxic environment, which often causes acute altitude sickness such as headache, heart palpitations, chest tightness, shortness of breath, fatigue, sleep disturbance, nausea, and vomiting. Some people may also experience confusion and high-altitude cerebral edema. , high altitude pulmonary edema, or even coma or death, seriously affecting the health of sojourners. Actively taking measures to prevent and treat hypoxia in the body plays a very important role in the prevention and treatment of acute mountain sickness brain, ischemic and hypoxic diseases, and myocardial ischemic and hypoxic diseases. At present, anti-hypoxic injury protective drugs are very sc...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P39/00A61P9/10
Inventor 景临林樊鹏程马慧萍蒋炜马骏贾正平
Owner 中国人民解放军联勤保障部队第九四〇医院
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