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Application of norwogonin to prepare anti-anoxia medicines

A technology of wogonin and anti-hypoxia drug, applied in the field of medicine, can solve the problems of lack of anti-hypoxic injury protective drugs and the like

Inactive Publication Date: 2014-12-31
马慧萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, anti-hypoxic injury protective drugs are very scarce, and it is urgent to develop efficient and economical anti-hypoxic injury protective drugs

Method used

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  • Application of norwogonin to prepare anti-anoxia medicines
  • Application of norwogonin to prepare anti-anoxia medicines
  • Application of norwogonin to prepare anti-anoxia medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, the preparation of norwogonin tablet

[0032]Raw material ratio: norwogonin (purity greater than 95%) 50.0g, starch 25.0g, microcrystalline cellulose (MCC) 15.0g, methylcellulose 6.0g, magnesium stearate 4.0g, a total of 200.0g'

[0033] Preparation process: according to the conventional process of preparing tablets in pharmacy. A total of 1000 tablets were made, each containing 50 mg of norwogonin.

Embodiment 2

[0034] Embodiment 2, the preparation of norwogonin capsule

[0035] Raw material ratio: 50.0g norwogonin (purity greater than 95%), 135.0g starch, 5.0g methylcellulose, 10.0g magnesium stearate, 200.0g in total;

[0036] Preparation process: according to the conventional process for preparing capsules in pharmacy. A total of 1000 capsules were made, and each capsule contained 50 mg of norwogonin.

Embodiment 3

[0037] Embodiment 3, the preparation of norwogonin dispersible tablet

[0038] Raw material ratio: norwogonin (purity greater than 95%) 50.0g, microcrystalline cellulose (MCC) 130.0g, croscarmellose sodium (cCMC-Na) 20.0g, a total of 200.0g;

[0039] Preparation process: Carry out according to the conventional process of preparing dispersible tablets in pharmacy. A total of 1000 tablets were made, each containing 50 mg of norwogonin.

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Abstract

The invention discloses application of norwogonin to prepare anti-anoxia medicines, which is a medicine new purpose of norwogonin. Through a mouse sealed anoxic tolerance experiment, a mouse acute pressure-reducing tolerance experiment, and a mouse plateau anoxic experiment simulated by a low-pressure oxygen cabin, norwogonin is proved to be capable of effectively eliminating excess free radicals generated by anoxia mouse brain tissue, improving the anti-oxidation capability and mitigating damage caused by anoxia, has substantial anti-oxidation activity, and has the effect better than acetazolamide. Anti-anoxia medicines prepared by taking norwogonin as an active composition are applicable to control anoxic damage or treat various anoxic pathology states caused by oxygen content reduction in external environment, also are applicable to prevent or treat anoxic pathology states of heart, brain, respiratory system and the like because the exterior normal oxygen content cannot fully arrive into bodies due to diseases and the like, and also are applicable to prevent or treat a pathology state of relative oxygen supplement insufficiency because the oxygen consumption demanded by body activity exceeds physiological mobilization ability.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the medical use of norwogonin, in particular to the application of norwogonin in preparing anti-hypoxic drugs. Background technique [0002] Oxygen is a key substance in the metabolism of oxygen-consuming organisms to generate energy. Insufficient oxygen supply will lead to metabolic abnormalities, increased production of ROS, and changes in some important genes, leading to a series of diseases, such as aging, inflammation, cardiovascular disease, stroke, brain damage, and neurodegenerative diseases. With the continuous acceleration of the pace of modern life, hypoxia has become a fairly common phenomenon. With the continuous advancement of the western development, more and more people are stationed in the plateau. The special low-pressure and hypoxic environment in the plateau area often makes people who rush into the plateau suffer from acute altitude sickness due to lack of oxygen. In se...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P39/00
Inventor 马慧萍景临林樊鹏程贾正平何蕾高荣敏
Owner 马慧萍
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