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Application of Chrysanthemum flavonoids in the preparation of anti-hypoxic drugs

An anti-hypoxic drug, the technology of chrysanthemum flavonoids, applied in the field of medicine

Active Publication Date: 2019-03-19
中国人民解放军联勤保障部队第九四〇医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are very few literature reports on the pharmacological activity of the flavonoids of chrysanthemum, only found that it has anti-inflammatory, anti-viral and free radical scavenging activities

Method used

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  • Application of Chrysanthemum flavonoids in the preparation of anti-hypoxic drugs
  • Application of Chrysanthemum flavonoids in the preparation of anti-hypoxic drugs
  • Application of Chrysanthemum flavonoids in the preparation of anti-hypoxic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Chestnut flavone tablet, the specific ingredients and content are:

[0051]

[0052] Prepare according to the conventional tablet method, and make 1000 tablets altogether, and each tablet contains 50 mg of Chrysanthemum japonica.

Embodiment 2

[0054] Chestnut flavonoid glue injection, the specific ingredients and content are:

[0055]

[0056] Prepared according to the conventional method of capsules, 1000 capsules are made in total, and each capsule contains 50 mg of cinnamon flavonoids.

Embodiment 3

[0058] Chestnut Flavone Dispersible Tablets

[0059]

[0060]

[0061] Prepared according to the conventional method of dispersible tablets, made a total of 1000 tablets, each containing 50 mg of cinnabar flavonoids.

[0062] Example 3

[0063] Chestnut Flavone Granules

[0064]

[0065] Prepare according to the conventional method of granules, and make 1000 bags in total, and each bag contains 50 mg of the flavonoid.

[0066] The pharmaceutical dosage form of the present invention is not completely limited thereto, and it can be prepared into more dosage forms, such as dropping pills, soft capsules, sustained and controlled release preparations, injections and the like.

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Abstract

The present invention discloses new application of mosloflavone in preparation of anti hypoxic drugs, a whole animal hypoxic experiment shows that the mosloflavone has significant anti-hypoxic activity, not only can extend the survival time of atmospheric pressure closed hypoxic mice, but can also extend the survival time of acute decompression hypoxic mice, and the mechanism may be associated with remission of hypoxia-induced energy deficiency and metabolic disorders, protecting of functions of ATPase on cell membrane and improvement of the antioxidant capacity.

Description

technical field [0001] The invention relates to a method for applying cinnabar flavonoids, which belongs to the field of medicine. Background technique [0002] Mosloflavone, also known as Mosloflavone, has a chemical name of 5-hydroxy-6,7-dimethoxyflavone, which was first isolated from Mosla soochwensis Matsuda by Wu Fengwu and others in 1981. , and later someone isolated the compound from three plants: chrysanthemum, rhubarb and maojiancao. There are very few literature reports on the pharmacological activity of Camelina flavonoids, and only found that it has anti-inflammatory, anti-viral and free radical scavenging activities. Contents of the invention [0003] The technical problem to be solved by the present invention is to overcome the existing defects and provide a new application of the flavonoid. [0004] The purpose of the present invention is specifically achieved through the following technical solutions: [0005] The application of the flavonoids of the che...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P39/00A61P9/10
Inventor 景临林马慧萍樊鹏程吴金华蒙萍贾正平
Owner 中国人民解放军联勤保障部队第九四〇医院
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