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Preparation method of medicine containing betel nut and its anti-hypoxia application

A technology of betel nut and medicine, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, and drug combinations, etc. It can solve problems such as the decrease of oxygen content in plateau environments, the impact of various human systems, and the inability to meet the body's oxygen needs.

Active Publication Date: 2020-11-03
中国人民解放军联勤保障部队第九四〇医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From the plains to the plateau, the air pressure will drop with the increase of altitude, and the oxygen content in the plateau environment will decrease, which cannot meet the body's demand for oxygen, and then have different degrees of impact on various systems of the human body.

Method used

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  • Preparation method of medicine containing betel nut and its anti-hypoxia application
  • Preparation method of medicine containing betel nut and its anti-hypoxia application
  • Preparation method of medicine containing betel nut and its anti-hypoxia application

Examples

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preparation example Construction

[0028] A method for preparing medicine containing betel nut ingredients, comprising the steps of:

[0029] A, take betel nut dried fruit slice, be ground into betel nut powder;

[0030] B. 1-3 kg of betel nut powder is placed in a dynamic heat reflux extraction concentrator, and 20-40 times the volume of absolute ethanol is added to the betel nut powder, and the temperature is 50-60 °C, and the extraction is refluxed for 3-4 hours to obtain an extract;

[0031] C. Evaporate the ethanol from the extract in the concentration tank until only 1L of the extract remains, concentrate the extract with a rotary evaporator until there is no ethanol in the extract, and dry the concentrate on a freeze dryer at -50°C before collecting;

[0032] D. Dissolve the above-mentioned dry matter in water to make a 3mg / mL sample solution, inject it into the AB-8 macroporous adsorption resin, and stop the adsorption when the polyphenol content in the effluent is 10% of the polyphenol content in the s...

Embodiment 1

[0041] A method for preparing medicine containing betel nut ingredients, comprising the steps of:

[0042] A, take betel nut dried fruit slice, be ground into betel nut powder, betel nut powder crosses 100 mesh sieves;

[0043] B, 1 kg of betel nut powder is placed in a dynamic heat reflux extraction concentrator, and 20 times the volume of absolute ethanol is added to the areca nut powder, and the temperature is 50 to 60 ° C for reflux extraction for 3 to 4 hours to obtain an extract;

[0044] C. Evaporate the ethanol from the extract in the concentration tank until only 1L of the extract remains, concentrate the extract with a rotary evaporator until there is no ethanol in the extract, and dry the concentrate on a freeze dryer at -50°C before collecting;

[0045] D. Dissolve the above-mentioned dry matter in water to make a 3mg / mL sample solution, inject it into the AB-8 macroporous adsorption resin, and stop the adsorption when the polyphenol content in the effluent is 10% ...

Embodiment 2

[0049] A method for preparing medicine containing betel nut ingredients, comprising the steps of:

[0050] A, take betel nut dried fruit slice, be ground into betel nut powder, betel nut powder crosses 100 mesh sieves;

[0051] B, 1 kg of betel nut powder is placed in a dynamic heat reflux extraction and concentrator, and 30 times the volume of absolute ethanol is added to the betel nut powder, and the temperature is 50 to 60° C., and the extraction is refluxed for 3 to 4 hours to obtain an extract;

[0052] C. Evaporate the ethanol from the extract in the concentration tank until only 1L of the extract remains, concentrate the extract with a rotary evaporator until there is no ethanol in the extract, and dry the concentrate on a freeze dryer at -50°C before collecting;

[0053] D. Dissolve the above-mentioned dry matter in water to make a 3mg / mL sample solution, inject it into the AB-8 macroporous adsorption resin, and stop the adsorption when the polyphenol content in the ef...

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Abstract

The invention relates to the technical field of natural medicines, and particularly relates to a method for preparing a medicine with an areca-nut component and anti-hypoxic application of the medicine. Overall animal tests show that an areca-nut extract has remarkable anti-hypoxic activity, and can not only prolong the survival time of hypoxia mice in a sealed normal pressure space, but also improve the high altitude anoxia resistance of hypoxia rats acutely entering into a real altitude situation. The mechanism is possibly related to effects that the minute ventilation volumes of the rats are increased, excessive free radicals in tissue are eliminated and the oxidation resistance is improved. The areca-nut extract is a natural component, is free of toxic or side effect on animals and human bodies and is applicable to anti-hypoxic application.

Description

technical field [0001] The invention relates to the technical field of natural medicines, in particular to a preparation method of medicines containing betel nut ingredients and its anti-hypoxia application. Background technique [0002] my country is the country with the largest plateau area in the world. Areas above 3,000 m above sea level account for 1 / 4 of my country's total land area, mainly distributed in Tibet, Qinghai, Yunnan, Gansu, Inner Mongolia and other western provinces. The Qinghai-Tibet Plateau has the "roof of the world" known as. Hypoxia is a notable feature of the plateau environment and is also the cause of altitude sickness. From the plains to the plateau, the air pressure will drop with the increase of altitude, and the oxygen content in the plateau environment will decrease, which cannot meet the body's demand for oxygen, and then have different degrees of impact on various systems of the human body. When rushing to high altitude areas, acute hypoxia ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/889A61P39/00A61P39/06A61K131/00
Inventor 王荣贾正平谢华靳婷李文斌
Owner 中国人民解放军联勤保障部队第九四〇医院
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