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Novel preparation of myricetin

A technology of myricetin and ethanol, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of not being suitable for mass production, long production cycle, environmental pollution, etc., and achieve low cost and short production cycle The effect of short, simple extraction process

Inactive Publication Date: 2008-11-05
赵全成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the extraction solvents used are flammable and explosive dangerous goods, and the production cycle is long, the cost is high, and it also pollutes the environment, so it is not suitable for mass production

Method used

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  • Novel preparation of myricetin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Add 1kg of snake grapes, add 15000ml of water, add potassium carbonate or potassium bicarbonate to adjust the pH value to 7.5-14 (preferably pH is 10), heat and decoct for 1.5h, filter, add 10000ml of water to the filter residue, decoct for 1h, filter, and filter the residue again Add 10000ml of water, decoct for 1 hour, filter, combine the three filtrates, concentrate to 2000ml, adjust the pH to 6.5 with dilute hydrochloric acid, leave it overnight, centrifuge, add 5000ml of 95% ethanol to the residue and heat to dissolve, add 25g of activated carbon and stir, filter, and recover the ethanol from the filtrate to No alcohol smell, add water to 1000ml, stand overnight, filter, and dry the filter residue to obtain yellow-green myricetin crystals, the yield is greater than 5.0%, and the content is greater than 95.0%.

Embodiment 2

[0025] Snake grape 1kg, add 15000ml water, add potassium phosphate or dipotassium hydrogen phosphate or sodium phosphate or disodium hydrogen phosphate to adjust the pH value to 7.5-14 (preferably pH is 10), heat and decoct for 2 hours, filter, add 10000ml water to the filter residue, Decoct for 1 hour, filter, add 10000ml of water to the filter residue, decoct for 1 hour, filter, combine the filtrates three times, concentrate to 2000ml, adjust the pH to 4.5 with dilute hydrochloric acid, leave it overnight, centrifuge, add 5000ml of 95% ethanol to the residue and heat to dissolve, add 25g of activated carbon Stir, filter, recover ethanol from the filtrate until it has no alcohol smell, add water to 1000ml, stand overnight, filter, and dry the filter residue to obtain yellow-green myricetin crystals with a yield greater than 5.0% and a content greater than 96.0%.

Embodiment 3

[0027] Snake grape 1kg, add 15000ml water, add ammonia water or ammonium carbonate or ammonium bicarbonate to adjust the pH value to 7.5-14 (preferably pH is 10), heat and decoct for 1h, filter, add 10000ml water to the filter residue, decoct for 1h, filter, filter residue Add 10000ml of water, decoct for 1 hour, filter, combine the three filtrates, concentrate to 2000ml, adjust the pH to 5.5 with dilute hydrochloric acid, leave it overnight, centrifuge, add 5000ml of 95% ethanol to the residue and heat to dissolve, add 25g of activated carbon to stir, filter, and recover ethanol from the filtrate Add water to 1000ml until there is no alcohol smell, stand overnight, filter, and dry the filter residue to obtain yellow-green myricetin crystals with a yield greater than 5.0% and a content greater than 96.0%.

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Abstract

The invention discloses a novel method for industrially preparing myricetin from stems and leaves of Ampelopsis sinica (Miq.) W.T.Wang of vitaceae Ampelopsis Michx or other plants of the vitaceae Ampelopsis. The novel preparation method includes the following steps: using alkaline liquor to adjust aqueous liquor or hydrous ethanol and methanol liquor into alkalescence to extract the total flavonoids in medicinal materials, condensing extraction liquor, using diluted acid to adjust the pH between 2 and 8, devitrifying and obtaining the crude extract; the crude extract is heated and extracted by using ethanol, methanol and acetone; the extraction liquor is decolored by active carbon; the myricetin can be obtained after devitrifying. The method has the advantages of simple technique, low cost, no pollution as well as being advanced, safe and practical.

Description

technical field [0001] The present invention provides a new method for extracting and preparing the raw material myricetin from the stems and leaves of Ampelopsis Michx (Ampelopsis sinica (Miq.) W.T.Wang) or other plants of the genus Ampelopsis Michx belonging to traditional Chinese medicine. , Natural medicine technical field. Background technique [0002] Snake grape is the stem and leaf of the plant of the genus Snake Grape in the grape family. Another name is sour vine, mountain grape, creeper, wild grape, firework vine, mountain radish, mountain dragon, mother bitter vine, sour ancient vine, yellow vine, Hejiazi vine, green grape, fake grape, water grape, etc. Wild snake grapes are abundant in Enshi area, especially Laifeng Dahe Town. According to "Compilation of Chinese Herbal Medicine", "Guangxi Medicinal Plant List", "Guangdong Medicinal Plant Handbook", "Shanghai Commonly Used Chinese Herbal Medicine" and other records, the medicine is sweet and light in nature, c...

Claims

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Application Information

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IPC IPC(8): C07D311/28A61K36/87
Inventor 赫玉芳南敏伦赵全成刘静月
Owner 赵全成
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