Myricetin extraction process

A technology of myricetin and extraction process, applied in the direction of organic chemistry and the like, can solve the problems of high extraction cost and complicated steps, and achieve the effects of product safety and reliability, simple process and high purity

Active Publication Date: 2010-09-22
HUZHOU SIFENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The myricetin extracted by this method has higher purity and high...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Get 150 grams of bayberry bark from March to May, grind it into a fine powder with a diameter of 3 to 5 mm, add 3 times the dilute sulfuric acid with a pH value of 4 of the volume of the fine powder, place the suspension in a thermostat, Keep the temperature at 70°C for 1 hour, then centrifuge the suspension with a centrifuge, remove the precipitate and leave the supernatant; add 80% ethanol at a concentration twice the volume of the supernatant to the supernatant, and stir slightly Let it stand for 2 hours, then extract the ethanol solution containing myricetin, and repeat the step 2 times; then use vacuum to concentrate under reduced pressure, the concentration condition is at 60°C, vacuum degree 3 ~ 4kpa, and concentrate to become the extraction 1 / 5 of the concentrated extract; then the concentrated extract was left to stand for 5 hours to precipitate myricetin, and the mother liquor was filtered to obtain the product. The yield of myricetin is about 20 grams, and th...

Embodiment 2

[0033] Get 150 grams of bayberry bark from March to May, grind it into a fine powder with a diameter of 3 to 5 mm, add 5 times the dilute sulfuric acid with a pH value of 5 of the volume of the fine powder, place the suspension in a thermostat, Keep the temperature at 80°C for 3 hours, then centrifuge the suspension with a centrifuge, remove the precipitate and leave the supernatant; add 90% ethanol at a concentration of 5 times the volume of the supernatant to the supernatant, and stir slightly Let it stand for 4 hours, then extract the ethanol solution containing myricetin, and repeat the step 3 times; then use vacuum to concentrate under reduced pressure, the concentration condition is at 70°C, vacuum degree 3 ~ 4kpa, and concentrate to become the extraction The concentrated extract of liquid 1 / 2; then the concentrated extract was left to stand for 10 hours to precipitate myricetin, and the mother liquor was filtered to obtain the product. The yield of myricetin is about 25...

Embodiment 3

[0035] Get 5 grams of bayberry bark from March to May, grind it into a fine powder with a diameter of 3 to 5 mm, add 4 times the volume of the fine powder to dilute sulfuric acid with a pH value of 4.5, place the suspension in a thermostat, Keep the temperature at 75°C for 3 hours, then centrifuge the suspension with a centrifuge, remove the precipitate and leave the supernatant; add 85% ethanol at a concentration 8 times the volume of the supernatant to the supernatant, and stir slightly Let it stand for 3 hours, then extract the ethanol solution containing myricetin, and repeat the step 3 times; then use vacuum to concentrate under reduced pressure, the concentration condition is at 65°C, vacuum degree 3 ~ 4kpa, and concentrate to become the extraction 1 / 4 of the concentrated extract; then the concentrated extract was left to stand for 10 hours to precipitate myricetin, and the mother liquor was filtered to obtain part of the product; then, at 85°C, the mother liquor filtered...

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PUM

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Abstract

The invention relates to a myricetin extraction process, which belongs to the technical field of natural pharmaceutical chemistry extraction. The myricetin extraction process comprises the following steps: (1) crushing raw material containing myricetin, adding acid the PH value of which is 4-5, and controlling the temperature to be 70-80 DEG C for 1-3 hours; (2) centrifuging the raw material treated by the step (1) to remove solid-contained matter, and keeping supernate; (3) adding 80-90 percent of ethanol in the supernate prepared by the step (2) in a proportion of 1:5-10 so as to extract the myricetin to prepare extracting solution, wherein the extracting time is controlled to be 2-4 hours; (4) concentrating the extracting solution at the temperature of 60-70 DEG C to prepare concentrated extracting solution, wherein the concentrated extracting solution is 1/5-1/3 of the extracting solution; and (5) enabling the concentrated extracting solution to stand for 5 hours or more, and thenfiltering out mother liquor to prepare the myricetin. The purity of the myricetin prepared by the extraction process can reach 80 percent, and the yield thereof is about 15 percent.

Description

technical field [0001] The invention relates to a process for extracting myricetin flavonoids, and belongs to the technical field of chemical extraction of natural medicines. Background technique [0002] Myricetin, scientific name 3,5,7,3',4',5'-hexahydroxyflavone. The structure is as follows: [0003] The physical and chemical properties of myricetin are as follows: the appearance is bright yellow-green powder crystal, easily soluble in alcohol, insoluble in water and organic solvents with low polarity. Myricetin has significant physiological activities such as protecting the liver, reducing enzymes, lowering blood sugar, anti-platelet activating factor, and enhancing the body's immune function. [0004] Chinese Journal of Modern Applied Pharmacology, 2000, 17 (3): 196 discloses the method of extracting and isolating myricetin (myricetin) from Yao tea, which is extracted with water and recrystallized repeatedly. method. The yield of this method is very low. [0005]...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07D311/40
Inventor 丁斌斌章月根
Owner HUZHOU SIFENG BIOTECH
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