Method for preparing natural material inorganic nanoparticle composite nano-fiber through electrostatic spinning

Abstract

The invention relates to a method for preparing natural material inorganic nanoparticle composite nano-fiber through electrostatic spinning, which comprises steps that a template is added into diluted aqueous alkali, the mixture is heated to 80-90 DEG C through an oil bath, mixed for 1-10 hours, gradually added with tetraethyl orthosilicate, centrifugally washed by deionized water and absolute ethyl alcohol sequentially, and dried and reflowed in HCL-ethanol mixed liquor to remove the template, so freeze dried mesoporous silicon is obtained; and natural materials are dissolved in the solvent to prepare the natural material solution, the mesoporous silicon is added into the natural material solution for electrostatic spinning, fumigating and crosslinking are carried out for 0-48 hours, so the natural material mesoporous silicon composite nano-fiber is obtained. The natural material inorganic nanoparticle composite nano-fiber which is prepared by the method has good biocompatibility, a simple preparation method and moderate reaction conditions, is low in experimental raw material price, has high drug-loading rate, can be controlled to be released for a long term, and can be applied in the biomedicine and tissue regeneration fields of growth factor and gene release of tissue engineering, cancer treatment and the like.

Description

technical field

[0001] The invention belongs to the field of nanofiber preparation, in particular to a preparation method of electrostatic spinning natural material inorganic nanoparticle composite nanofiber. Background technique

[0002] There are many ways to prepare nanofibers, such as: template synthesis, self-assembly, phase separation and electrospinning techniques. Compared with other techniques, electrospinning has its significant advantages. The template synthesis method refers to the use of a mold with a nanostructure to form a material into a fiber or catheter structure. The biggest advantage of this method is that many materials such as metals, electronically conductive polymers, semiconductor materials, and carbon materials can be prepared into nanoscale by using templates. fibers or conduits, however, this method cannot achieve the preparation of one-to-one continuous nanofibers. The phase separation method mainly uses unused solvents, freezing and drying met...

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