Method for preparing natural material inorganic nanoparticle composite nano-fiber through electrostatic spinning

A technology of composite nanofibers and inorganic nanoparticles, which can be used in fiber processing, chemical characteristics of fibers, and medical preparations with inactive ingredients, etc. Low cost, good application prospect, simple operation effect

Inactive Publication Date: 2012-11-21
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Bioactive molecules have poor stability and are easily degraded by some enzymes in the body or self-degraded when encountering acid and alkali. At the same time, the short half-life requires frequent administration, which is likely to cause adverse reactions or even toxic reactions to patients.

Method used

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  • Method for preparing natural material inorganic nanoparticle composite nano-fiber through electrostatic spinning
  • Method for preparing natural material inorganic nanoparticle composite nano-fiber through electrostatic spinning
  • Method for preparing natural material inorganic nanoparticle composite nano-fiber through electrostatic spinning

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Gelatin Nanofiber Scaffolds Loaded with Mesoporous Silica

[0031] (1) Preparation of silica nanoparticles by template extraction method: Add 1.0g of template agent (hexadecyltrimethyl) to 500ml of 3% NaOH dilute alkaline aqueous solution, heat the oil bath to 80°C, and stir for 1.5h , add 5 ml of tetraethyl orthosilicate dropwise, wash and centrifuge with deionized water and ethanol, repeat three times and then dry. Reflux in a mixture of 5 ml of 38% HCL and 500 ml of absolute ethanol to remove the template agent to obtain freeze-dried mesoporous silicon;

[0032] (2) Prepare gelatin hexafluoroisopropanol solution with a mass volume ratio of 1:10 (g / ml);

[0033] (3) The amount of mesoporous silicon added is 10% relative to the mass of gelatin, the solution is sucked with a syringe, the voltage is adjusted to 18kV, the advancing speed is 1.0ml / h, the receiving distance is 15cm, the room temperature is 60%, and the humidity is 60%. Gelatin-mesoporous silica composite ...

Embodiment 2

[0035] Silk fibroin nanofiber scaffold loaded with mesoporous silicon

[0036] (1) Preparation of silica nanoparticles by template extraction method: Add 1.0g of template agent (hexadecyltrimethyl) to 500ml of 3% NaOH dilute alkaline aqueous solution, heat the oil bath to 80°C, and stir for 1.5h , add 5 ml of tetraethyl orthosilicate dropwise, wash and centrifuge with deionized water and ethanol, repeat three times and then dry. Reflux in a mixture of 5 ml of 38% HCL and 500 ml of absolute ethanol to remove the template agent to obtain freeze-dried mesoporous silicon;

[0037] (2) Prepare silk fibroin hexafluoroisopropanol solution with a mass volume ratio of 1:5 (g / ml);

[0038] (3) Add 20% of the mass of mesoporous silicon relative to the mass of silk fibroin, draw the solution with a syringe, adjust the voltage to 18kV, push the speed to 0.6ml / h, receive the distance to 20cm, room temperature, and humidity to 60%, Silk fibroin-mesoporous silicon composite nanofibers were ...

Embodiment 3

[0041] Silk fibroin nanofiber scaffold loaded with mesoporous silicon

[0042](1) Preparation of silica nanoparticles by template extraction method: Add 1.0g of template agent (hexadecyltrimethyl) to 500ml of 3% NaOH dilute alkaline aqueous solution, heat the oil bath to 80°C, and stir for 1.5h , add 5 ml of tetraethyl orthosilicate dropwise, wash and centrifuge with deionized water and ethanol, repeat three times and then dry. Reflux in a mixture of 5 ml of 38% HCL and 500 ml of absolute ethanol to remove the template agent to obtain freeze-dried mesoporous silicon;

[0043] (2) Prepare silk fibroin aqueous solution with a mass volume ratio of 3:10 (g / ml);

[0044] (3) Add the mass of mesoporous silicon equivalent to 15% of the mass of silk fibroin, draw the solution with a syringe, adjust the voltage to 20kV, the advancing speed to 0.3ml / h, the receiving distance to 15cm, the temperature to 30°C, and the humidity to be 50%, the silk fibroin-mesoporous silicon composite nan...

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Abstract

The invention relates to a method for preparing natural material inorganic nanoparticle composite nano-fiber through electrostatic spinning, which comprises steps that a template is added into diluted aqueous alkali, the mixture is heated to 80-90 DEG C through an oil bath, mixed for 1-10 hours, gradually added with tetraethyl orthosilicate, centrifugally washed by deionized water and absolute ethyl alcohol sequentially, and dried and reflowed in HCL-ethanol mixed liquor to remove the template, so freeze dried mesoporous silicon is obtained; and natural materials are dissolved in the solvent to prepare the natural material solution, the mesoporous silicon is added into the natural material solution for electrostatic spinning, fumigating and crosslinking are carried out for 0-48 hours, so the natural material mesoporous silicon composite nano-fiber is obtained. The natural material inorganic nanoparticle composite nano-fiber which is prepared by the method has good biocompatibility, a simple preparation method and moderate reaction conditions, is low in experimental raw material price, has high drug-loading rate, can be controlled to be released for a long term, and can be applied in the biomedicine and tissue regeneration fields of growth factor and gene release of tissue engineering, cancer treatment and the like.

Description

technical field [0001] The invention belongs to the field of nanofiber preparation, in particular to a preparation method of electrostatic spinning natural material inorganic nanoparticle composite nanofiber. Background technique [0002] There are many ways to prepare nanofibers, such as: template synthesis, self-assembly, phase separation and electrospinning techniques. Compared with other techniques, electrospinning has its significant advantages. The template synthesis method refers to the use of a mold with a nanostructure to form a material into a fiber or catheter structure. The biggest advantage of this method is that many materials such as metals, electronically conductive polymers, semiconductor materials, and carbon materials can be prepared into nanoscale by using templates. fibers or conduits, however, this method cannot achieve the preparation of one-to-one continuous nanofibers. The phase separation method mainly uses unused solvents, freezing and drying met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F4/00D01F9/00D01F1/10D01D5/00A61L27/44A61L27/02A61L27/50A61K9/00A61K47/04A61K47/36A61K47/42
Inventor 王红声崔呈俊何创龙冯炜
Owner DONGHUA UNIV
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