The invention relates to a method for preparing 
natural material inorganic 
nanoparticle composite nano-
fiber through electrostatic 
spinning, which comprises steps that a template is added into diluted aqueous alkali, the mixture is heated to 80-90 DEG C through an 
oil bath, mixed for 1-10 hours, gradually added with 
tetraethyl orthosilicate, centrifugally washed by deionized water and absolute ethyl 
alcohol sequentially, and dried and reflowed in HCL-
ethanol mixed liquor to remove the template, so freeze dried mesoporous 
silicon is obtained; and natural materials are dissolved in the 
solvent to prepare the 
natural material solution, the mesoporous 
silicon is added into the 
natural material solution for electrostatic 
spinning, fumigating and crosslinking are carried out for 0-48 hours, so the natural material mesoporous 
silicon composite nano-
fiber is obtained. The natural material inorganic 
nanoparticle composite nano-
fiber which is prepared by the method has good 
biocompatibility, a simple preparation method and moderate 
reaction conditions, is low in experimental 
raw material price, has high 
drug-
loading rate, can be controlled to be released for a long term, and can be applied in the 
biomedicine and tissue regeneration fields of 
growth factor and 
gene release of 
tissue engineering, 
cancer treatment and the like.