Method for producing liquid core microcapsule by electrostatic spraying

An electrostatic spray and microcapsule technology, applied in the field of microcapsule technology and polymer materials, can solve the problems of high price of reagent polylysine, poor biocompatibility, low capsule membrane strength, etc., and achieve low price and capsule formation. The effect of good performance and easy-to-obtain wall materials

Inactive Publication Date: 2008-04-02
UNIV OF SHANGHAI FOR SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the existing preparation sodium alginate-polylysine-sodium alginate (APA) and sodium alginate-chitosan-sodium alginate (ACA) microcapsules are used, but due to poor biocompatibility, capsule The low strength and the high price of the reagent polylysine used limit its application to a certain extent.

Method used

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  • Method for producing liquid core microcapsule by electrostatic spraying
  • Method for producing liquid core microcapsule by electrostatic spraying

Examples

Experimental program
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Effect test

Embodiment 1

[0026] The tortoise shell powder is made into a water decoction in advance and filtered through a mesh screen; 2% calcium chloride solution is mixed with high-viscosity carboxymethyl cellulose sodium, and then mixed with the tortoise shell water decoction, and the sprayer uses a syringe and a flat needle without burrs , through a microcapsule forming device in a high-voltage electrostatic field, spray it into a sodium alginate solution with a concentration of 0.6% that is constantly stirred; the capsuled tortoise shell slow-release microcapsules are filtered and rinsed 2-3 times with distilled water, and placed in 1% Continue to solidify in the calcium chloride solution for 10 minutes, then filter out the microcapsules, and the tortoise shell water decoction is wrapped in a slow-release membrane. Rinse 2-3 times with distilled water before storing. The obtained tortoiseshell microcapsules have a particle size of about 0.12mm and a film thickness of about 0.14mm.

Embodiment 2

[0028] The tortoise shell powder is pre-made into a water decoction and filtered through a mesh screen; 2.5% calcium chloride solution is mixed with high-viscosity carboxymethyl cellulose sodium, and then mixed with the tortoise shell water decoction, and the sprayer uses a syringe and a flat needle without burrs , through a microcapsule forming device in a high-voltage electrostatic field, spray it into a sodium alginate solution with a concentration of 0.75% that is constantly stirred; the capsuled tortoise shell slow-release microcapsules are filtered and rinsed 2-3 times with distilled water, and placed in 1.2% The calcium chloride solution is solidified for 10 minutes, and then the microcapsules are filtered out, and the tortoise shell water decoction is wrapped in a slow-release membrane. Rinse 2-3 times with distilled water before storing. The obtained tortoiseshell microcapsules have a particle size of about 0.97mm and a film thickness of about 0.07mm.

Embodiment 3

[0030] The tortoise shell powder is pre-made into a water decoction and filtered through a mesh screen; 3% calcium chloride solution is mixed with high-viscosity carboxymethyl cellulose sodium, and then mixed with the tortoise shell water decoction, and the sprayer uses a syringe and a flat needle without burrs , through a microcapsule forming device in a high-voltage electrostatic field, spray it into a continuously stirred sodium alginate solution with a concentration of 1%. The calcium chloride solution is solidified for 10 minutes, and then the microcapsules are filtered out, and the tortoise shell water decoction is wrapped in a slow-release membrane. Rinse 2-3 times with distilled water before storing. The obtained tortoiseshell microcapsules have a particle size of about 0.85mm and a film thickness of about 0.09mm.

[0031] The prepared tortoise shell sustained-release preparation (microcapsule) has uniform particle size, good encapsulation performance, simple process,...

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Abstract

The invention provides a method for preparation of liquid core microcapsule with static sprayer: calcium chloride solution of 2-3 percent is mixed with thickening agent and then is uniformly mixed with core material substance; a certain amount of mixed solution is taken out and then is put into solution containing sodium alginate of 0.6-1.5 percent with static sprayer while adopting a flat needle for adhesive deposite or an injection needle as a nozzle; after capsulated, liquid core sodium alginate microcapsule is filtered and then is cleaned with purified water; then liquid core sodium alginate microcapsule is put into calcium chloride solution for continuous solidification of 5-10 minutes; then microcapsule is filtered and then is cleaned with purified water; at last microcapsule is stored in storage solution with calcium ion concentration of 0.05-0.01 percent. High viscosity malt dextrin or sodium carbonxymethyl cellulose or xanthan gum is adopted as thickening agent. Microcapsule prepared with the invention has liquid core, with uniform particle size, good sacculation performance, simple process and high membrane thickness, therefore, microcapsule has high mechanical strength and can be widely used in the field of pharmaceutical chemical engineering, artificial organ implantation and food processing, etc.

Description

technical field [0001] The invention relates to a method for preparing liquid-core microcapsules by electrostatic spraying, and belongs to the technical fields of microcapsule technology and polymer materials. Background technique [0002] Microcapsule technology has been successfully applied in fields such as biochemical industry, food and medicine. And the preparation method of microcapsule has many kinds. Although the existing preparation sodium alginate-polylysine-sodium alginate (APA) and sodium alginate-chitosan-sodium alginate (ACA) microcapsules are used, but due to poor biocompatibility, capsule The low strength and the high price of the reagent polylysine used limit its application. Contents of the invention [0003] In order to overcome the above disadvantages, the invention discloses a method for preparing liquid core microcapsules by electrostatic spraying. [0004] The purpose of the present invention is to prepare liquid-core microcapsules and obtain micr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/04
Inventor 李保国张武杰汤亭亭
Owner UNIV OF SHANGHAI FOR SCI & TECH
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