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Bionic construction method of artificial organics

An artificial organ and layered structure technology, which is applied in the field of bionic construction of artificial organs, can solve the problems of difficulty in building structures, inability to realize bionic shape of organs, and complexity, and achieve the effect of being beneficial to transplantation, maintaining similarity, and ensuring molding.

Inactive Publication Date: 2015-03-04
XI AN JIAOTONG UNIV
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Problems solved by technology

However, these methods cannot realize the bionic appearance of organs, and more importantly, it is difficult to construct multi-scale and multi-level organ vascular structures with complex structures for cell growth.

Method used

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  • Bionic construction method of artificial organics

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Embodiment Construction

[0017] The present invention will be described in detail below in conjunction with drawings and embodiments.

[0018] Take building an artificial liver as an example.

[0019] A method for constructing an artificial liver, comprising the following steps:

[0020] 1) Using medical CT and MRI techniques to reconstruct the three-dimensional computer model of the macroscopic shape of the artificial liver;

[0021] 2) Export the reconstructed 3D computer model in step 1) in STL format, use 3D printing technology to prepare a resin model similar in shape to the natural liver, sputter a layer of metal film evenly on the surface of the resin model as a receiver, and then use Electrospinning technology evenly deposits a layer of micro-nano fiber structure layer with a thickness of 50-500 microns on the surface of the metal film, and then removes the resin model to obtain the artificial liver film. The material used for the micro-nano fiber structure layer is polylactic acid-hydroxyl ...

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Abstract

A bionic construction method of artificial organics includes: reconstructing a three-dimensional computer model of macroscopic appearance of an artificial organ, preparing a resin model close to a natural organ in shape by means of the 3D (three-dimensional) printing technique, sputtering a metal film to the surface of the resin model, depositing a micro-nano fiber structure layer, removing the resin model to obtain an artificial organ film, importing the three-dimensional computer model into a computer for materialization, designing a bionic vessel micro-channel structure, building a layered structure model, preparing bionic extracellular matrix of the artificial organic by means of the 3D printing technique, wrapping the bionic extracellular matrix with the artificial organ film, and sewing the contact edges of the two layers of the artificial organ film to obtain the artificial organ. The method is applicable to construction of the multi-scale multi-layer vessel structured artificial organic having bionic appearance and complex structure and used for cell growth.

Description

technical field [0001] The invention relates to the technical field of tissue and organ engineering, in particular to a bionic construction method of an artificial organ. Background technique [0002] Tissue and organ engineering has specific requirements for bionic organ structures: interconnected three-dimensional microfluidic network, bionic extracellular matrix environment and bionic organ shape. The three-dimensional microfluidic network interpenetrates to allow cells to adhere to the wall to grow to form blood vessels, the bionic extracellular matrix allows cells to aggregate and grow to form tissue units, and the shape of bionic organs facilitates the implantation of artificial organs in the body. Therefore, how to manufacture such highly bionic artificial organs has become one of the key issues in tissue engineering. [0003] Traditional construction methods include phase separation, freezing, porogen pore analysis, and lamination. However, these methods cannot rea...

Claims

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Application Information

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IPC IPC(8): A61F2/02
Inventor 贺健康刘亚雄陈若梦李涤尘靳忠民
Owner XI AN JIAOTONG UNIV
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