Degradable bioactive composite ceramic microsphere stent material, and preparation method and application thereof

A technology of bioactive ceramics and composite ceramics, used in tissue regeneration, medical science, prosthesis, etc., can solve problems such as porous ceramic stents that have not yet been found, and improve the ability to promote osteogenesis and vascularization, and is conducive to osteogenesis and vascularization. Effect

Inactive Publication Date: 2017-04-19
GUANGDONG UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology describes new materials that use decomposability ceramia (CZO), an oxide commonly found naturally occurring mineral called pyroxene). These compositions allow for controlled control over their physical characteristics through various methods like chemical or thermal treatment. They may contain other elements like calcium phosphate, silicon dioxyphthaluminate, boron nitride, etc., making them suitable for medical applications where they could help promote healing processes on damaged tissues.

Problems solved by technology

This patented technical problem addressed in this patent relates to improving the design of prostheatostatic wound healing systems based on natural bones called calcified ossicles, specifically those derived from human teeth. These mineral substances naturally exist within the dentin matrix and play various roles like cell adhesion, nerve root remodeling, angiogenesis, and stimulation of stem cells. To create these artificial structures, porous metallurgically treated spongificial bone screw cores must match the desired characteristics while keeping the original architecture intact without compromising any weakness. Additionally, current methods require expensive equipment and involve complicated procedures.

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  • Degradable bioactive composite ceramic microsphere stent material, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] The preparation method of the β-tricalcium phosphate composite ceramic microsphere support is as follows:

[0034] (1) Using (NH4)2HPO4, CaCO3, MgCO3, Na2CO3 as raw materials, the molar percentage of oxides CaO:P2O5:MgO:Na2O corresponding to each substance is 40:40:10:10, mix the raw materials evenly, put In the furnace, heat to 1000°C and keep it warm for 1 hour to obtain a clear glass solution, then pour the glass solution into water to quench, collect glass particles, dry at 150°C, grind, and pass through a 1000-mesh sieve to obtain a low melting point Bio-glass powder;

[0035] (2) The steps of preparing β-tricalcium phosphate composite microspheres by droplet condensation method are as follows: dissolving gelatin at a ratio of 8 g / 100 mL in deionized water at 30 °C to make gelatin with a concentration of 8% (w / v) solution. The β-tricalcium phosphate powder and the bioglass powder prepared in step (1) are uniformly mixed, and the mass ratio of β-tricalcium phosphate...

Embodiment 2

[0039] The preparation method of calcium silicate composite ceramic microsphere support is:

[0040] (1) Using B2O3, P2O3, CaCO3, SiO2, and Na2CO3 as raw materials, the molar percentage of the oxides B2O3:P2O5:CaO:SiO2:Na2O corresponding to each substance is 4:6:30:45:15, and mix the raw materials evenly , put it into a furnace, heat it to 1200°C, keep it warm for 3 hours to obtain a clear glass solution, then pour the glass solution into water to quench, collect glass particles, dry at 150°C, grind, pass through a 1000-mesh sieve, that is Obtain low melting point bioglass powder;

[0041] (2) The steps of preparing calcium silicate composite microspheres by droplet condensation method are as follows: dissolve xanthan gum in 30°C deionized water at a ratio of 4g / 100mL to make xanthan gum with a concentration of 4% (w / v). Raw gum solution. Sodium hydroxypropyl cellulose was dissolved in 60°C deionized water at a ratio of 3g / 100mL to make a sodium hydroxypropyl cellulose solut...

Embodiment 3

[0045] The preparation method of the hydroxyapatite / β-tricalcium phosphate / calcium silicate composite microsphere scaffold is as follows:

[0046] (1): Using (NH4)2HPO4, CaCO3, SrCO3, and Na2CO3 as raw materials, the molar percentage of oxides P2O5:CaO:SrO:Na2O corresponding to each substance is 45:40:5:10, mix the raw materials evenly, and put Put it into a furnace, heat it to 1200°C, keep it warm for 3 hours to obtain a clear glass solution, then pour the glass solution into water to quench, collect glass particles, dry at 150°C, grind, and pass through a 1000-mesh sieve to obtain a low-density glass solution. Melting point bioglass powder;

[0047] (2) The steps of preparing calcium silicate composite microspheres by droplet condensation method are as follows: dissolve pectin in deionized water at 30°C at a ratio of 0.3g / 100mL to make pectin with a concentration of 0.3% (w / v). glue solution. Dissolve cyclodextrin at a ratio of 10g / 100mL in deionized water at 60°C to make ...

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Abstract

The invention discloses a degradable bioactive composite ceramic microsphere stent material, and a preparation method and an application thereof. The preparation method comprises the steps of preparing degradable bioactive composite ceramic microspheres from a degradable bioactive ceramic and low-melting-point bioglass as solid-phase raw materials by adopting an inverse emulsion method or a liquid drop condensation method; and putting the composite ceramic microspheres into a cylindrical hole cavity of a mould, performing natural stacking, filling the hole cavity with the microspheres until a certain height is reached, putting a cylindrical male die with a certain weight into the hole cavity for realizing axial pressing of the microspheres, slowly increasing the temperature to 600-1,500 DEG C, and performing sintering for 5-300 minutes to obtain the degradable bioactive composite ceramic microsphere stent material. According to the degradable bioactive composite ceramic microsphere stent material, the bioactive ceramic is taken as a matrix, and the low-melting-point bioglass is added as a sintering aid; and the degradable bioactive composite ceramic microsphere stent prepared with the microsphere sintering method is high in strength, good in three-dimensional connectivity, controllable in hole diameter, fully degradable and good in bone induction and vascularization effects, is used for bone repair materials, and has a very good application prospect.

Description

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Claims

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Application Information

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Owner GUANGDONG UNIV OF TECH
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