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Preparation method and application of bioactive composite film hemostasis dressing

A hemostatic dressing and bioactive technology are applied in the field of preparation of bioactive composite film hemostatic dressings, which can solve the problems of poor water resistance, high brittleness and low film strength, and achieve the effects of good film-forming performance, low cost and good barrier performance.

Active Publication Date: 2014-10-01
山东贝诺医药生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the disadvantages of low strength, high brittleness and poor water resistance of native starch film, its application is limited. In recent years, studies have shown that the application of starch as a film is more and more widely used through the modification of starch.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 5g of alginic acid, dissolve it with 0.1mol / L sodium hydroxide solution, prepare a sodium alginate solution with a mass percent concentration of 2%, and let it stand; take 5g of cross-linked hydroxypropyl starch and dissolve it in 166ml of distilled water , gelatinized at 90°C for 0.5h to obtain a cross-linked hydroxypropyl starch paste solution, which is ready for use; take 100 ml of sodium alginate solution and cross-linked hydroxypropyl starch paste solution according to the volume ratio of 1:1 Mix, then add a mixture of stearic acid and palmitic acid with a mass ratio of 1:1, the added amount is 4g, blend at 80°C for 0.5h, then filter the blended solution, defoam under reduced pressure, and statically After putting it in place, it is cast to form a film, and the modified starch / sodium alginate composite film is obtained, which can be dried in vacuum.

Embodiment 2

[0023] Weigh 10g of alginic acid, dissolve it with 0.1mol / L sodium hydroxide solution, prepare a sodium alginate solution with a mass percentage concentration of 3.5%, and let it stand; take 8g of cross-linked hydroxypropyl starch and dissolve it in 228ml of distilled water , gelatinized at 95°C for 40 minutes to obtain a cross-linked hydroxypropyl starch paste solution, which is ready for use; take 120ml of sodium alginate solution and 80ml of cross-linked hydroxypropyl starch paste according to the volume ratio of 3:2 The solution was mixed, and then a mixture of stearic acid and palmitic acid with a mass ratio of 1:1 was added, the amount added was 5 g, blended for 40 minutes at 85 ° C, and then the blend was filtered, degassed under reduced pressure, and statically After setting, it can be cast into a film and dried in vacuum.

Embodiment 3

[0025] Weigh 12g of alginic acid, dissolve it with 0.1mol / L sodium hydroxide solution, prepare a sodium alginate solution with a mass percentage concentration of 4.0%, and let it stand; take 9g of cross-linked hydroxypropyl starch and dissolve it in 240ml of distilled water , gelatinized at 95°C for 50 minutes to obtain a cross-linked hydroxypropyl starch paste solution, and set aside; take 134ml of sodium alginate solution and 66ml of cross-linked hydroxypropyl starch paste according to the volume ratio of 2:1 The solution was mixed, and then a mixture of stearic acid and palmitic acid with a mass ratio of 1:1 was added, the amount added was 6 g, blended for 50 min at 85 ° C, and then the blend was filtered, degassed under reduced pressure, and statically After setting, it can be cast into a film and dried in vacuum.

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Abstract

The invention relates to a preparation method and application of a bioactive composite film hemostasis dressing. The preparation method of the bioactive composite film hemostasis dressing comprises the following steps: dissolving alginic acid in a sodium hydroxide solution to obtain a sodium alga acid solution, dissolving cross-linked hydroxypropylated starch in distilled water for pasting and obtaining a cross-linked hydroxypropylated starch paste solution, mixing the sodium alga acid solution with the cross-linked hydroxypropylated starch paste solution at a volume ratio of (1:1)-(3:1), adding fatty substances into the mixed solution for improving the barrier property of the film, preparing the bioactive composite film by using a tape casting method, and drying in vacuum. The film material prepared by the preparation method has good biocompatibility and biodegradability and has the special functions of inhibiting bacteria, stopping bleeding, promoting healing and the like; when the film material is contacted with a wound, the film material is capable of quickly absorbing water in the blood, keeping a humid environment and effectively sealing the hemorrhagic wound.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method and application of a bioactive composite film hemostatic dressing. Background technique [0002] Trauma bleeding is one of the important diseases that endanger human health and life safety. At present, traditional dressings such as medical absorbent cotton gauze, cotton pads and vaseline gauze are the most widely used dressings for skin wounds in clinical practice. The traditional dressing has a net-like weaving structure, which is cheap, relatively simple in production process, wide in source of raw materials, soft in texture, has strong absorption capacity, can prevent wound exudate from accumulating, and has a certain degree of protective effect on wound healing. Widely used in skin wounds. However, traditional dressings also have obvious disadvantages, such as not keeping the wound moist and delaying wound healing; wound granulation tissue...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44
Inventor 刘维峰程凯
Owner 山东贝诺医药生物科技有限公司
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